Singularities of nevirapine metabolism: from sex-dependent differences to idiosyncratic toxicity

Autor: Sofia A. Pereira, Aline T. Marinho, Clara Gonçalves-Dias, Umbelina Caixas, Catarina Charneira, M. Matilde Marques, Alexandra M. M. Antunes, Joana P. Miranda, Emília C. Monteiro

Publikováno v: Drug Metabolism Reviews. 51:76-90

Nevirapine (NVP) is a first-generation non-nucleoside reverse transcriptase inhibitor widely used for the treatment and prophylaxis of human immunodeficiency virus infection. The drug is taken throughout the patient's life and, due to the availabilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::487d2be433a7c2b7d9273549a1a239c6
https://doi.org/10.1080/03602532.2019.1577891

In vitro evaluation of novel reverse transcriptase inhibitors TAF (tenofovir alafenamide) and OBP-601 (2,3-didehydro-3-deoxy-4-ethynylthymidine) against multi-drug resistant primary isolates of HIV-2

Autor: Inês Bártolo, Perpétua Gomes, Inês V. Pinto, Nuno Taveira, Umbelina Caixas, Pedro Borrego, Fátima Gonçalves

Publikováno v: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP

New antiretroviral drugs are needed to treat HIV-2 infected patients failing therapy. Herein, we evaluate the activity of novel reverse transcriptase inhibitors tenofovir alafenamide (TAF) and OBP-601(2,3-didehydro-3-deoxy-4-ethynylthymidine) against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad33099c170bad98790b16b08156a38
https://hdl.handle.net/10400.26/30647

Quantification of the arylesterase activity of paraoxonase-1 in human blood

Autor: Alexandra M. M. Antunes, Aline T. Marinho, Umbelina Caixas, Joana R. Batuca, Emília C. Monteiro, Sofia A. Pereira, Clara G. Dias

Publikováno v: Anal. Methods. 6:289-294

Paraoxonase-1 (PON1) is known as a free-radical scavenging system associated with circulating serum high-density lipoprotein (HDL). PON1 catalyzes the hydrolysis of multiple compounds such as arylesters, lactones and hydroperoxides. The arylesterase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbda1903fa38c43c693bd9549831eb6c
https://doi.org/10.1039/c3ay41527a

Monitoring of the lactonase activity of paraoxonase-1 enzyme in HIV-1-infection

Autor: Gabriela Almeida, Judit Morello, Clara G. Dias, Sofia A. Pereira, Emília C. Monteiro, Umbelina Caixas, Karina Soto, Aline T. Marinho

Publikováno v: Journal of the International AIDS Society

Paraoxonase-1 (PON1) is a high-density lipoprotein (HDL)-associated enzyme known as a free radical scavenging system (1). PON-1 has three main activities, responsible for its antioxidant and anti-inflammatory potential: paraoxonase, arylesterase and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4617cd6306ef283533766eceea2deb1a
https://pubmed.ncbi.nlm.nih.gov/25397432

Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions

Autor: M. Matilde Marques, Alexandra M. M. Antunes, Shrika G. Harjivan, Umbelina Caixas, Teresa Branco, Emília C. Monteiro, Aline T. Marinho, Sofia A. Pereira, Patrícia M. Rodrigues

Publikováno v: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP

OBJECTIVES: Nevirapine is widely used for the treatment of HIV-1 infection; however, its chronic use has been associated with severe liver and skin toxicity. Women are at increased risk for these toxic events, but the reasons for the sex-related diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a51ccbb98a5cb3d294a2f97e3e5e5c3
https://pubmed.ncbi.nlm.nih.gov/24051761