Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Umashankar Singh"'
Autor:
Ishani Morbia, Praveen Kumar, Aditi Lakshmi Satish, Akanksha Mudgal, Subhamoy Datta, Umashankar Singh
Publikováno v:
BMC Genomic Data, Vol 25, Iss 1, Pp 1-20 (2024)
Abstract CGGBP1 is a GC-rich DNA-binding protein which is important for genomic integrity, gene expression and epigenome maintenance through regulation of CTCF occupancy and cytosine methylation. It has remained unclear how CGGBP1 integrates multiple
Externí odkaz:
https://doaj.org/article/d800aed12eb943a4bcc6336fc8857cc7
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)
Abstract Background Inhibition of DNA-binding of proteins by small-molecule chemicals holds immense potential in manipulating the activities of DNA-binding proteins. Such a chemical inhibition of DNA-binding of proteins can be used to modulate proces
Externí odkaz:
https://doaj.org/article/a7569ecc62ab481898f4b0e349293fc0
Publikováno v:
BMC Genetics, Vol 21, Iss 1, Pp 1-21 (2020)
Abstract Background The human CGGBP1 binds to GC-rich regions and interspersed repeats, maintains homeostasis of stochastic cytosine methylation and determines DNA-binding of CTCF. Interdependence between regulation of cytosine methylation and CTCF o
Externí odkaz:
https://doaj.org/article/cac7722ca5074cd9aa4add864bb39cd5
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-22 (2019)
Abstract Background CGGBP1 is a repeat-binding protein with diverse functions in the regulation of gene expression, cytosine methylation, repeat silencing and genomic integrity. CGGBP1 has also been identified as a cooperator of histone-modifying enz
Externí odkaz:
https://doaj.org/article/3f745bf099644182ae5113eeb10de8e4
Publikováno v:
BMC Research Notes, Vol 11, Iss 1, Pp 1-7 (2018)
Abstract Objectives Although CpG methylation is well studied, mechanisms of non-CpG methylation in mammals remains elusive. Studying proteins with non-CpG cytosine methylation-sensitive DNA-binding, such as human CGGBP1, can unveil cytosine methylati
Externí odkaz:
https://doaj.org/article/f29d7c33c7c94bb3a92316c5a6589c7e
Publikováno v:
Cancer Informatics, Vol 18 (2019)
Genome-wide occupancy of several histone modifications in various cell types has been studied using chromatin immunoprecipitation (ChIP) sequencing. Histone occupancy depends on DNA sequence features like inter-strand symmetry of base composition and
Externí odkaz:
https://doaj.org/article/921e6ca8ca29484a9e86b1df301407fe
Publikováno v:
Canadian Journal of Biotechnology, Vol 1, Iss Special Issue, Pp 111-111 (2017)
DNA cytosine methylation occurs in all three sequence contexts: CpG and CHG (symmetrically on the two strands) and CHH (asymmetrically on one strand). While mechanisms of CpG methylation regulation are well studied; the non-CpG methylation is beginni
Externí odkaz:
https://doaj.org/article/28ef3bfda90444aaa06ddc2a050d8d99
Publikováno v:
Canadian Journal of Biotechnology, Vol 1, Iss Special Issue, Pp 110-110 (2017)
Genome organisation and gene expression is regulated by specific DNA sequences that include “insulator elements”. Insulator proteins, such as CTCF bind to insulator elements to block spreading of silent chromatin in-cis or inhibit interactions be
Externí odkaz:
https://doaj.org/article/1a03311a44754750a0759da9c6edee1e
Publikováno v:
Canadian Journal of Biotechnology, Vol 1, Iss Special Issue, Pp 43-43 (2017)
Introduction: Histone modification, a covalent post-translational modification of histone proteins, influences gene expression by altering chromatin structure giving rise to key characteristics to various cell types. While interaction of histone prot
Externí odkaz:
https://doaj.org/article/a7107bd7b85948a9b62110864bb15655
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5050 (2009)
BACKGROUND: Though the Nuclear factor 1 family member NFIX has been strongly implicated in PDGFB-induced glioblastoma, its molecular mechanisms of action remain unknown. HSF1, a heat shock-related transcription factor is also a powerful modifier of c
Externí odkaz:
https://doaj.org/article/1e866443ce554a1283d53a6238035337