Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Umar Mehraj"'
Publikováno v:
Results in Chemistry, Vol 10, Iss , Pp 101694- (2024)
It is predicted that over 29 million individuals will receive a cancer diagnosis in 2040, making cancer one of the major causes of death globally. One of the biggest obstacles to being overcome in the treatment of cancer is drug resistance, which is
Externí odkaz:
https://doaj.org/article/2a8cdf34b3394831bc67875e39b5dff0
Autor:
Shazia sofi, Umar Mehraj, Nusrat Jan, Abdullah Almilaibary, Irshad Ahmad, Fuzail Ahmad, Manzoor Ahmad Mir
Publikováno v:
Saudi Journal of Biological Sciences, Vol 31, Iss 2, Pp 103916- (2024)
B-cell lymphoma/leukemia gene-2 (Bcl-2) is the primary proto-oncogene that has been shown to work by preventing apoptosis/programmed cell death. Bcl-2 combines a variety of cell-generated signals associated to the survival and death of cells. In glio
Externí odkaz:
https://doaj.org/article/fcee97ebaab44d33ab735f131c22657b
Autor:
Umar Mehraj, Nissar Ahmad Wani, Abid Hamid, Mustfa Alkhanani, Abdullah Almilaibary, Manzoor Ahmad Mir
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Although advances in diagnostics and therapeutics have prolonged the survival of triple-negative breast cancer (TNBC) patients, metastasis, therapeutic resistance, and lack of targeted therapies remain the foremost hurdle in the effective management
Externí odkaz:
https://doaj.org/article/e25dcab2afa949f89ef3b4c3de36057d
Autor:
Umar Mehraj, Irfan Ahmad Mir, Mahboob ul Hussain, Mustfa Alkhanani, Nissar Ahmad Wani, Manzoor Ahmad Mir
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Doxorubicin is a commonly used chemotherapeutic agent to treat several malignancies, including aggressive tumors like triple-negative breast cancer. It has a limited therapeutic index owing to its extreme toxicity and the emergence of drug resistance
Externí odkaz:
https://doaj.org/article/6f9bd18847f04528a908b4472a76cccc
Publikováno v:
Advances in Cancer Biology - Metastasis, Vol 4, Iss , Pp 100037- (2022)
Background: Baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, member of the inhibitor of apoptosis (IAP), is a multitasking protein and among the top 100 deregulated genes in breast cancer patients. It negatively regulates apoptosis of
Externí odkaz:
https://doaj.org/article/75657d24563d40378ff33b6a2fc366a3
Autor:
Manzoor Ahmad Mir, Umar Mehraj, Hina Qayoom, Shazia Shafi, Pzd Farhana, Syed Mohammed Basheeruddin Asdaq
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:3025-3037
Background: DNA Topoisomerase II Alpha (TOP2A), a protein-coding gene, is central to the replication process and has been found deregulated in several malignancies, including breast cancer. Several therapeutic regimens have been developed and approve
Autor:
Mohammad Nadeem Lone, Shazia Gul, Umar Mehraj, Shazia Sofi, Abid Hamid Dar, Shabir Ahmad Ganie, Nissar Ahmad Wani, Manzoor Ahmad Mir, Mohammed A. Zargar
Publikováno v:
Applied Biochemistry and Biotechnology.
Autor:
Mohd W. Nasser, Abid Hamid, Nissar A. Wani, Umar Mehraj, Raid Al-Baradie, Manzoor Ahmad Mir, Mohammad Haris, Ajaz A. Bhat, Bader Alshehri, Mohammed A. Zargar, Muzafar A. Macha, Rais A. Ganai, Surinder K. Batra
Publikováno v:
Cellular Oncology. 44:1209-1229
Breast cancer (BC), the second most common cause of cancer-related deaths, remains a significant threat to the health and wellness of women worldwide. The tumor microenvironment (TME), comprising cellular components, such as cancer-associated fibrobl
Autor:
Hina Qayoom, Umar Mehraj, Shazia Sofi, Shariqa Aisha, Abdullah Almilaibary, Mustfa Alkhanani, Manzoor Ahmad Mir
Publikováno v:
Medical Oncology. 39
The CDKs are known to play a critical role in cell cycle regulation process. Among the different groups of CDKs, CDK4 overexpression/hyperactivation is found to be present in many cancers and a specific CDK4 inhibitor, palbociclib has been recently a
Autor:
Shazia Sofi, Umar Mehraj, Hina Qayoom, Shariqa Aisha, Abdullah Almilaibary, Mustfa Alkhanani, Manzoor Ahmad Mir
Publikováno v:
Medical Oncology. 39
Cell cycle dysregulation is a characteristic hallmark of malignancies, which results in uncontrolled cell proliferation and eventual tumor formation. Cyclin-dependent kinase 1 (CDK1) is a member of the family of cell cycle regulatory proteins involve