Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Umadevi S. Sajjan"'
Autor:
Elizabeth S. McCluskey, Nathan Liu, Abhimaneu Pandey, Nathaniel Marchetti, Steven G. Kelsen, Umadevi S. Sajjan
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Background Airway basal cells (BC) from patients with chronic obstructive pulmonary disease (COPD) regenerate abnormal airway epithelium and this was associated with reduced expression of several genes involved in epithelial repair. Querceti
Externí odkaz:
https://doaj.org/article/d14b48c0a16f415ebc5c8ed861df820d
Publikováno v:
ERJ Open Research, Vol 9, Iss 3 (2023)
Background Airway epithelial cells from patients with COPD show suboptimal innate immune responses to nontypeable Haemophilus influenzae (NTHi) and Toll-like receptor (TLR)2 ligands despite expressing TLR2 similar to normal airway epithelial cells, b
Externí odkaz:
https://doaj.org/article/c44980e043fa4e80937bcd2330807f49
Publikováno v:
BMJ Open Respiratory Research, Vol 7, Iss 1 (2020)
IntroductionQuercetin is a plant flavonoid and has potent antioxidant and anti-inflammatory properties. In a preclinical model of chronic obstructive pulmonary disease (COPD), quercetin reduced markers of both oxidative stress and lung inflammation a
Externí odkaz:
https://doaj.org/article/841a77adb1f3430482c15205949bcff4
Autor:
Mohammad Farazuddin, Rahul Mishra, Yaxun Jing, Vikram Srivastava, Adam T Comstock, Umadevi S Sajjan
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0199612 (2018)
Acute exacerbations are the major cause of morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD). Rhinovirus, which causes acute exacerbations may also accelerate progression of lung disease in these patients. Current
Externí odkaz:
https://doaj.org/article/69c1bbd0c4164ddc9f2e0fce6a7d6989
Toll-like receptors (TLR) play a pivotal role in stimulating innate immune responses of airway epithelial cells to bacterial and viral infections. Airway epithelial cells from patients with chronic obstructive pulmonary disease (COPD) show suboptimal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ae5df15f82db5039cd4c03c285f21c4
https://doi.org/10.21203/rs.3.rs-1734139/v1
https://doi.org/10.21203/rs.3.rs-1734139/v1
Autor:
Nathaniel Xander, Wuyan Li, Hymavathi Reddy Vari, Nathaniel Marchetti, Rewees Eskandar, Sudhir Bolla, Umadevi S. Sajjan
Publikováno v:
J Immunol
IFN responses to viral infection are necessary to establish intrinsic antiviral state, but if unchecked can lead to heightened inflammation. Recently, we showed that TLR2 activation contributes to limitation of rhinovirus (RV)–induced IFN response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045aa94ed95bb64c541d7975053d39da
https://doi.org/10.4049/jimmunol.1900165
https://doi.org/10.4049/jimmunol.1900165
Rhinovirus-induces progression of lung disease in a mouse model of COPD via IL-33/ST2 signaling axis
Autor:
Hymavathi Reddyvari, Umadevi S. Sajjan, Sudhir Kotnala, Rahul Mishra, Mohammad Farazuddin, Wuyan Li, Vikram Srivastava, Joao Antonio Gimenes
Publikováno v:
Clinical Science. 133:983-996
Rhinovirus (RV), which is associated with acute exacerbations, also causes persistent lung inflammation in patients with chronic obstructive pulmonary disease (COPD), but the underlying mechanisms are not well-known. Recently, we demonstrated that RV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fef5789fc217c280c1b85bc78426b70
https://doi.org/10.1042/cs20181088
https://doi.org/10.1042/cs20181088
Autor:
Umadevi S. Sajjan, Yerin Kim, Nathaniel Marchetti, Charu Rajput, Karim Bahmed, Sudhir Kotnala, Sudhir Bolla, Hymavathi Reddyvari, Beata Kosmider
Publikováno v:
Clinical science (London, England : 1979). 135(17)
Dipeptidyl peptidase 4 (DPP4) expression is increased in the lungs of chronic obstructive pulmonary disease (COPD). DPP4 is known to be associated with inflammation in various organs, including LPS-induced acute lung inflammation. Since non-typeable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579cf1bb4857aafc6c265446d35daeea
https://pubmed.ncbi.nlm.nih.gov/34405230
https://pubmed.ncbi.nlm.nih.gov/34405230
Autor:
Shyamala eGanesan, Umadevi S Sajjan
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 1 (2012)
Burkholderia cenocepacia is an opportunistic respiratory pathogen of individuals with cystic fibrosis (CF). It is one of the highly transmissible species of Burkholderia cepacia complex and very resistant to almost all the antibiotics. Approximately
Externí odkaz:
https://doaj.org/article/59f227a32c054b93b5f36d540f5e3225
Autor:
Benjamin L Unger, Andrea N Faris, Shyamala Ganesan, Adam T Comstock, Marc B Hershenson, Umadevi S Sajjan
Publikováno v:
PLoS Pathogens, Vol 8, Iss 10, p e1002969 (2012)
Bacterial infections following rhinovirus (RV), a common cold virus, are well documented, but pathogenic mechanisms are poorly understood. We developed animal and cell culture models to examine the effects of RV on subsequent infection with non-typea
Externí odkaz:
https://doaj.org/article/24feaa96ac1748f389a2597cb98e9445