Výsledky vyhledávání - "Uma Sinha-Datta"

The HTLV-I p30 Interferes with TLR4 Signaling and Modulates the Release of Pro- and Anti-inflammatory Cytokines from Human Macrophages

Autor: Abhik Datta, Christophe Nicot, Uma Sinha-Datta, Shilpa Buch, Navneet K. Dhillon

Publikováno v: Journal of Biological Chemistry. 281:23414-23424

Whereas adaptive immunity has been extensively studied, very little is known about the innate immunity of the host to HTLV-I infection. HTLV-I-infected ATL patients have pronounced immunodeficiency associated with frequent opportunistic infections, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22995e2888ed09ceb69c5689d5766a8
https://doi.org/10.1074/jbc.m600684200

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Transcriptional activation of hTERT through the NF-κB pathway in HTLV-I–transformed cells

Autor: Izumi Horikawa, Abhik Datta, Mirdad Kazanji, Janitzia C. Sigler-Nicot, J. Carl Barrett, Christophe Nicot, Eriko Michishita, Uma Sinha-Datta, Megan Brown

Publikováno v: Blood. 104:2523-2531

In immortal cells, the existence of a mechanism for the maintenance of telomere length is critical. In most cases this is achieved by the reactivation of telomerase, a cellular reverse transcriptase that prevents telomere shortening. Here we report t

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https://doi.org/10.1182/blood-2003-12-4251

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Nuclear export and expression of human T-cell leukemia virus type 1 tax/rex mRNA are RxRE/Rex dependent

Autor: Xue Tao Bai, Nga Ling Ko, Uma Sinha-Datta, Christophe Nicot, Marcia Bellon

Publikováno v: Journal of virology. 86(8)

Human T-cell leukemia virus type 1 (HTLV-1) is a complex retrovirus associated with the lymphoproliferative disease adult T-cell leukemia/lymphoma (ATL) and the neurodegenerative disorder tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP

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https://pubmed.ncbi.nlm.nih.gov/22318152

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Human T-cell lymphotrophic virus type I rex and p30 interactions govern the switch between virus latency and replication

Autor: Uma Sinha-Datta, Abhik Datta, Madeleine Duc Dodon, Christophe Nicot, Sofiane Ghorbel

Publikováno v: The Journal of biological chemistry. 282(19)

Human T-cell lymphotrophic virus type I Rex and p30 are both RNA binding regulatory proteins. Rex is a protein that interacts with a responsive element and stimulates nuclear export of incompletely spliced viral RNAs thereby increasing production of

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https://pubmed.ncbi.nlm.nih.gov/17360706

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Label-free interaction analysis as a tool to demonstrate biosimilarity of therapeutic monoclonal antibodies

Autor: Dhananjay Wadgaonkar, Srijit Khan, Uma Sinha-Datta

Publikováno v: Biosimilars. :83

Uma Sinha-Datta, Srijit Khan, Dhananjay WadgaonkarFast Trak, GE Healthcare Life Science, John F Welch Technology Centre, Bangalore, IndiaAbstract: In the biosimilar eon, where various analytical platforms are needed to show biosimilarity, we demonstr

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https://doi.org/10.2147/bs.s85537

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Human T-cell leukemia virus type I p30 nuclear/nucleolar retention is mediated through interactions with RNA and a constituent of the 60 S ribosomal subunit

Autor: Miroslav Dundr, Uma Sinha-Datta, Sofiane Ghorbel, Megan Brown, Genoveffa Franchini, Christophe Nicot

Publikováno v: The Journal of biological chemistry. 281(48)

Human T-cell leukemia virus type I is the etiological agent of adult T-cell leukemia/lymphoma, an aggressive and fatal lymphoproliferative malignancy. The virus has evolved strategies to escape immune clearance by remaining latent in most infected ce

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https://pubmed.ncbi.nlm.nih.gov/17008317

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Persistent inhibition of telomerase reprograms adult T cell leukemia to p53-dependent senescence

Autor: Yves Lepelletier, Thomas A. Waldmann, Olivier Hermine, Abhik Datta, Uma Sinha-Datta, Christophe Nicot, Ali Bazarbachi, Marcia Bellon, Danielle Canioni

Publikováno v: Blood
Blood, American Society of Hematology, 2006, 108, pp.1021-1029

The antiviral thymidine analog azidothymidine (AZT) is used to treat several virus-associated human cancers. However, to date the mechanism of AZT action remains unclear and thus, reasons for treatment failure are unknown. Adult T-cell leukemia/lymph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03f6af26aae52eb4714b10e8ec8fce0
https://hal.archives-ouvertes.fr/hal-00022487

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Molecular cloning and characterization of Antheraea mylitta cytoplasmic polyhedrosis virus polyhedrin gene and its variant forms

Autor: Uma Sinha-Datta, Ananta K. Ghosh, Venkata R M Chavali

Publikováno v: Biochemical and biophysical research communications. 332(3)

The segments 10 (S10) of the 11 double stranded RNA genomes from Antheraea mylitta cytoplasmic polyhedrosis virus (AmCPV) encoding a novel polyhedrin polypeptide was converted to cDNA, cloned, and sequenced. Three cDNA clones consisting of 1502 (AmCP

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https://pubmed.ncbi.nlm.nih.gov/15907799

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Tax-mediated re-routing of the HTLV-1 p13 protein to nuclear speckles

Autor: Genoveffa Franchini, Cynthia A. Pise-Masison, Robyn Washington Parks, Vibeke Andresen, Uma Sinha-Datta, Risaku Fukumoto, Valentina Cecchinato, Christophe Nicot

Publikováno v: Retrovirology
Retrovirology, Vol 8, Iss Suppl 1, p A125 (2011)

Human T-cell Leukemia Virus type-1 (HTLV-1) is highly immunogenic and has low variability so tight regulation of its expression is essential for virus maintenance in vivo. HTLV-1 replication is positively regulated by Tax and Rex, and negatively by t

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