Výsledky vyhledávání - "Uma S Gautam"

Akademický článek

LAG-3 potentiates the survival of Mycobacterium tuberculosis in host phagocytes by modulating mitochondrial signaling in an in-vitro granuloma model.

Autor: Bonnie L Phillips, Uma S Gautam, Allison N Bucsan, Taylor W Foreman, Nadia A Golden, Tianhua Niu, Deepak Kaushal, Smriti Mehra

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0180413 (2017)

CD4+ T-cell mediated Th1 immune responses are critical for immunity to TB. The immunomodulatory protein, lymphocyte activation gene-3 (LAG-3) decreases Th1-type immune responses in T-cells. LAG-3 expression is significantly induced in the lungs of ma

Externí odkaz: https://doaj.org/article/f601410534d047899879c97264b15662

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Mycobacterium tuberculosis sensor kinase DosS modulates the autophagosome in a DosR-independent manner

Autor: Jaya Sivaswami Tyagi, Uma S. Gautam, Tianhua Niu, Smriti Mehra, Deepak Kaushal, Xavier Alvarez, Priyanka Kumari

Publikováno v: Communications Biology, Vol 2, Iss 1, Pp 1-12 (2019)
Communications Biology

Dormancy is a key characteristic of the intracellular life-cycle of Mtb. The importance of sensor kinase DosS in mycobacteria are attributed in part to our current findings that DosS is required for both persistence and full virulence of Mtb. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593b6d3d66d25af8fe24638121df1db9
http://link.springer.com/article/10.1038/s42003-019-0594-0

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Akademický článek

Role of TNF in the altered interaction of dormant Mycobacterium tuberculosis with host macrophages.

Autor: Uma S Gautam, Smriti Mehra, Muhammad H Ahsan, Xavier Alvarez, Tianhua Niu, Deepak Kaushal

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e95220 (2014)

Mycobacterium tuberculosis (Mtb) persists within lung granulomas, despite being subjected to diverse stress conditions, including hypoxia. We hypothesized that the response of host phagocytes to Mtb experiencing hypoxia is radically altered and desig

Externí odkaz: https://doaj.org/article/fef28747156149b5b6cbbc6aade004a5

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ClgR contributes to pulmonary pathology but not bacterial growth in Mycobacterium tuberculosis infection

Autor: Uma S. Gautam, Deepak Kaushal

BackgroundThe Clp proteases regulator, ClgR, is encoded in the Mycobacterium tuberculosis (Mtb) genome by Rv2745c gene (clgR). ClgR is required to clear damaged proteins, thereby preventing their accumulation in the cell. It also controls the availab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4359ba112f0cf24da758fb308375314b
https://doi.org/10.1101/2020.02.04.934901

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Impact of integrated nutrient management on ginger production

Autor: Uma S. Gautam, A. K. Singh, Jai Singh

Publikováno v: Bangladesh Journal of Botany. 44:341-344

An experiment was evaluated in an integrated approach of nutrient management on two ginger cultivars under irrigation domains in Kymore Plateau and Satpura Hills zone of central India for three consecutive years during the kharif season. The results

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::349a6fa2defc539bb7b33e3a104c36c8
https://doi.org/10.3329/bjb.v44i2.38528

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