Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Uma M Sharma"'
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 1 (2010)
Coxiella burnetii is the etiologic agent of human Q fever and targets alveolar phagocytic cells in vivo wherein the pathogen generates a phagolysosome-like parasitophorous vacuole (PV) for replication. C. burnetii displays a prolonged growth cycle, m
Externí odkaz:
https://doaj.org/article/b01e3751fddb4c4cbd5a0f9ed3d1058e
Autor:
Uma M Sharma, R Christopher Chase, Jitka A. I. Virag, Susan D. Kent, Victoria A Chan, Maliha Bhuiyan, Smrithi Valsaraj, K'Shylah S Whitehurst, Heather K Estes
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 16
International Journal of Molecular Sciences, Vol 21, Iss 5811, p 5811 (2020)
Volume 21
Issue 16
International Journal of Molecular Sciences, Vol 21, Iss 5811, p 5811 (2020)
Background: EphrinA1-Fc abolishes acute I/R injury and attenuates nonreperfused cardiac injury 4 days after permanent occlusion in mice. The goal of this study was to assess the capacity of a single intramyocardial administration of ephrinA1-Fc at th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc3065f42b098b9a0136cc7a6ee6b16
https://pubmed.ncbi.nlm.nih.gov/32823610
https://pubmed.ncbi.nlm.nih.gov/32823610
Publikováno v:
Circulation Research. 125
Each year, an estimated 805,000 US citizens have a new or recurrent myocardial infarction (MI), causing over 360,000 deaths. We have previously reported that a single intramyocardial administration of recombinant ephrinA1-Fc, a member of the ephrinA/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45527dd2260464d9a7241cd87ea8246c
https://doi.org/10.1161/res.125.suppl_1.590
https://doi.org/10.1161/res.125.suppl_1.590
Autor:
Maria J. Torres, Brinda Sarathy, Kelsey L. McLaughlin, Omar M. Sharaf, Smrithi Valsaraj, Jitka A Virag, K'Shylah S Whitehurst, Uma M Sharma, Darrell Neufer, Julie L. Horton, Randall H. Renegar
Publikováno v:
Circulation Research. 123
EphrinA1, a receptor tyrosine kinase ligand expressed in the plasma membrane of healthy cardiomyocytes, is reduced following acute myocardial ischemia (I)/reperfusion (R) injury in mice. Intramyocardial injection of recombinant EphrinA1-Fc at the tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::590f2c9fbb17879f44bcdc893f39d46b
https://doi.org/10.1161/res.123.suppl_1.556
https://doi.org/10.1161/res.123.suppl_1.556
Autor:
Omar M. Sharaf, Justin Parks, Jeffrey J. Brault, Uma M Sharma, Randall H. Renegar, Jitka A. I. Virag, Smrithi Valsaraj, P. Darrell Neufer, Brinda Sarathy, Julie L. Horton, Kelsey H. Fisher-Wellman, Maria J. Torres, Kelsey L. McLaughlin, K'Shylah S Whitehurst
Publikováno v:
Life Sci
Aims Intracardiac injection of recombinant EphrinA1-Fc immediately following coronary artery ligation in mice reduces infarct size in both reperfused and non-reperfused myocardium, but the cellular alterations behind this phenomenon remain unknown. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288bae609a513e2dae101bb1ec06d0af
https://doi.org/10.1016/j.lfs.2019.117053
https://doi.org/10.1016/j.lfs.2019.117053
Autor:
Daniel E. Voth, Uma M. Sharma, S. Kauser Hussain, Richard C. Kurten, Laura J. MacDonald, Joseph G. Graham
Publikováno v:
Cellular Microbiology. 15:1012-1025
Summary The intracellular bacterial pathogen Coxiella burnetii is a category B select agent that causes human Q fever. In vivo, C. burnetii targets alveolar macrophages wherein the pathogen replicates in a lysosome-like parasitophorous vacuole (PV).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ccacc73674c160e0e86d7987c642a86
https://doi.org/10.1111/cmi.12096
https://doi.org/10.1111/cmi.12096
Coxiella burnetii causes human Q fever, a zoonotic disease that presents with acute flu-like symptoms and can result in chronic life-threatening endocarditis. In human alveolar macrophages, C. burnetii uses a Dot/Icm type IV secretion system (T4SS) t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79ea46f57b73a2ba91ee09bf2169bae
https://europepmc.org/articles/PMC4333474/
https://europepmc.org/articles/PMC4333474/
Autor:
Jitka A. I. Virag, Uma M Sharma, David W Wert, Augustin DuSablon, Robert C Chase, Eleftherios Vlahos, K'Shylah S Whitehurst, Justin Parks, Heather K Estes
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 12, p e0189307 (2017)
PLoS ONE, Vol 12, Iss 12, p e0189307 (2017)
EphrinA1, a membrane-bound receptor tyrosine kinase ligand expressed in healthy cardiomyocytes, is lost in injured cells following myocardial infarction. Previously, we have reported that a single intramyocardial injection of chimeric ephrinA1-Fc at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c54cacc306852ee02054da89098509e9
https://doi.org/10.1371/journal.pone.0189307
https://doi.org/10.1371/journal.pone.0189307
Publikováno v:
Journal of bacteriology. 195(14)
The intracellular bacterial agent of Q fever, Coxiella burnetii, translocates effector proteins into its host cell cytosol via a Dot/Icm type IV secretion system (T4SS). The T4SS is essential for parasitophorous vacuole formation, intracellular repli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb88bf5b15e875500ff3559135531559
https://pubmed.ncbi.nlm.nih.gov/23687269
https://pubmed.ncbi.nlm.nih.gov/23687269
Autor:
Anders Omsland, Georgios Samoilis, Uma M. Sharma, Diane C. Cockrell, Dale Howe, Paul A. Beare, Robert A. Heinzen, Daniel E. Voth
The intracellular bacterial pathogen Coxiella burnetii directs biogenesis of a phagolysosome-like parasitophorous vacuole (PV), in which it replicates. The organism encodes a Dot/Icm type IV secretion system (T4SS) predicted to deliver to the host cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42fe1e356ec39f56edc90931c89aca3
https://europepmc.org/articles/PMC3067651/
https://europepmc.org/articles/PMC3067651/