Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Uma D. Kabra"'
Publikováno v:
Metabolites, Vol 11, Iss 6, p 405 (2021)
The development of obesity and type 2 diabetes (T2D) has been associated with impaired mitochondrial function. In pancreatic beta (β) cells, mitochondrial energy metabolism plays a central role in triggering and controlling glucose-stimulated insuli
Externí odkaz:
https://doaj.org/article/32217d8165b742a5be7240810ce513ad
Autor:
Dhiraj G. Kabra, Katrin Pfuhlmann, Cristina García-Cáceres, Sonja C. Schriever, Veronica Casquero García, Adam Fiseha Kebede, Esther Fuente-Martin, Chitrang Trivedi, Kristy Heppner, N. Henriette Uhlenhaut, Beata Legutko, Uma D. Kabra, Yuanqing Gao, Chun-Xia Yi, Carmelo Quarta, Christoffer Clemmensen, Brian Finan, Timo D. Müller, Carola W. Meyer, Marcelo Paez-Pereda, Kerstin Stemmer, Stephen C. Woods, Diego Perez-Tilve, Robert Schneider, Eric N. Olson, Matthias H. Tschöp, Paul T. Pfluger
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Histone deacetylases (HDACs) regulate energy metabolism in peripheral tissues, but whether HDACs expressed in the brain influence systemic metabolism is unknown. Here the authors show that hypothalamic HDAC5 expression is affected by the diet and HDA
Externí odkaz:
https://doaj.org/article/05d180e6a43443a4a0aaf1a16b919fe2
Publikováno v:
International Journal of Pharmaceutical Chemistry and Analysis. 8:103-111
Three-dimensional protein structure prediction from amino acid sequence has been a thought-provoking task for decades, but it of pivotal importance as it provides a better understanding of its function. In recent years, the methods for prediction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8790f12ad0d1ef7ceb2edabbafe2f3d
https://doi.org/10.18231/j.ijpca.2021.021
https://doi.org/10.18231/j.ijpca.2021.021
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 20; Pages: 12338
Mitochondrial dynamics and bioenergetics are central to glucose-stimulated insulin secretion by pancreatic beta cells. Previously, we demonstrated that a disturbance in glucose-invoked fission impairs insulin secretion by compromising glucose catabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::3ed9c43690e50593aaf99819aa4bcce0
Publikováno v:
International journal of molecular sciences. 23(20)
Mitochondrial dynamics and bioenergetics are central to glucose-stimulated insulin secretion by pancreatic beta cells. Previously, we demonstrated that a disturbance in glucose-invoked fission impairs insulin secretion by compromising glucose catabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eca8589345f2ab4a06c06ad991b137fa
https://pubmed.ncbi.nlm.nih.gov/36293194
https://pubmed.ncbi.nlm.nih.gov/36293194
Publikováno v:
Metabolites
Volume 11
Issue 6
Metabolites, Vol 11, Iss 405, p 405 (2021)
Metabolites 11:405 (2021)
Volume 11
Issue 6
Metabolites, Vol 11, Iss 405, p 405 (2021)
Metabolites 11:405 (2021)
The development of obesity and type 2 diabetes (T2D) has been associated with impaired mitochondrial function. In pancreatic beta (β) cells, mitochondrial energy metabolism plays a central role in triggering and controlling glucose-stimulated insuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00558534456da922383b8b9ece7770a
https://doi.org/10.3390/metabo11060405
https://doi.org/10.3390/metabo11060405
Autor:
Charles Affourtit, Uma D. Kabra, Adriana Migliorini, Moritz Gegg, Stephen C. Woods, Heiko Lickert, Katrin Pfuhlmann, Olle Korsgren, Susanne Keipert, Matthias H. Tschöp, Paul T. Pfluger, Martin Jastroch, Daniel Lamp
Publikováno v:
Diabetes
In pancreatic β-cells, mitochondrial bioenergetics control glucose-stimulated insulin secretion. Mitochondrial dynamics are generally associated with quality control, maintaining the functionality of bioenergetics. By acute pharmacological inhibitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abdaee6f136457e89f1af53563bdf945
https://pubmed.ncbi.nlm.nih.gov/28174288
https://pubmed.ncbi.nlm.nih.gov/28174288
Autor:
Adriana Migliorini, Martin Jastroch, Katrin Pfuhlmann, Daniel Lamp, Moritz Gegg, Heiko Lickert, Charles Affourtit, Matthias H. Tschöp, Paul T. Pfluger, Stephen C. Woods, Uma D. Kabra, Olle Korsgren, Susanne Keipert
Publikováno v:
Diabetes 66, 1247-1257 (2017)
In pancreatic β-cells, mitochondrial bioenergetics control glucose-stimulated insulin secretion. Mitochondrial dynamics are generally associated with quality control, maintaining the functionality of bioenergetics. By acute pharmacological inhibitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4ff358406b9cdf10254b2b245ad8e3
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=50653
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=50653
Publikováno v:
Journal of Heterocyclic Chemistry. 48:1351-1355
As a part of systematic investigation on synthesis and biological activities, some new derivatives of 2-ethyl-3-(substituted benzothiazole-2′-yl)–[3H]-quinazolin-4-ones 3 have been synthesized, and the structures of the compounds were confirmed b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa736ac40f07bfbdaf28cc656bd64756
https://doi.org/10.1002/jhet.754
https://doi.org/10.1002/jhet.754
Autor:
Varun Pandey, Matthias Selbach, Lena Eliasson, Hans-Hermann Wessels, Jean Hausser, Robert P. Zinzen, Thomas Rathjen, Matthias D. Sury, Inês G. Mollet, Martin Jastroch, Sudhir Gopal Tattikota, Uma D. Kabra, Marc R. Friedländer, Matthias H. Tschöp, Aditya Khedkar, Matthew N. Poy, Mihaela Zavolan, Sebastian Kadener
Publikováno v:
J. Biol. Chem. 290, 20284-20294 (2015)
Journal of Biological Chemistry; 290(33), pp 20284-20294 (2015)
Journal of Biological Chemistry; 290(33), pp 20284-20294 (2015)
In response to fasting or hyperglycemia, the pancreatic β-cell alters its output of secreted insulin; however the pathways governing this adaptive response are not entirely established. While the precise role of microRNAs (miRNAs) is also unclear, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25305055dc44bba95c561cfa5fda4b3
https://europepmc.org/articles/PMC4536436/
https://europepmc.org/articles/PMC4536436/