Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Uma, Shankavaram"'
De novo TLK1 and MDM1 mutations in a patient with a neurodevelopmental disorder and immunodeficiency
Autor:
Marina Villamor-Payà, María Sanchiz-Calvo, Jordann Smak, Lynn Pais, Malika Sud, Uma Shankavaram, Alysia Kern Lovgren, Christina Austin-Tse, Vijay S. Ganesh, Marina Gay, Marta Vilaseca, Gianluca Arauz-Garofalo, Lluís Palenzuela, Grace VanNoy, Anne O’Donnell-Luria, Travis H. Stracker
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109984- (2024)
Summary: The Tousled-like kinases 1 and 2 (TLK1/TLK2) regulate DNA replication, repair and chromatin maintenance. TLK2 variants underlie the neurodevelopmental disorder (NDD) ‘Intellectual Disability, Autosomal Dominant 57’ (MRD57), characterized
Externí odkaz:
https://doaj.org/article/9fee7cb1f61b4d7e99ce9dad37542610
Autor:
Andra Valentina Krauze, Michael Sierk, Trinh Nguyen, Qingrong Chen, Chunhua Yan, Ying Hu, William Jiang, Erdal Tasci, Theresa Cooley Zgela, Mary Sproull, Megan Mackey, Uma Shankavaram, Daoud Meerzaman, Kevin Camphausen
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/3bd14230d32b49928cd917fea00de0bf
Publikováno v:
BMC Medical Genomics, Vol 16, Iss 1, Pp 1-8 (2023)
Abstract Cancer researchers often seek user-friendly interactive tools for validation, exploration, analysis, and visualization of molecular profiles in cancer patient samples. To aid researchers working on the both low- and high-grade gliomas, we de
Externí odkaz:
https://doaj.org/article/cc72266a4e30434f9c98a11de7ac49e2
Autor:
Andra Valentina Krauze, Michael Sierk, Trinh Nguyen, Qingrong Chen, Chunhua Yan, Ying Hu, William Jiang, Erdal Tasci, Theresa Cooley Zgela, Mary Sproull, Megan Mackey, Uma Shankavaram, Daoud Meerzaman, Kevin Camphausen
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundGlioblastomas (GBM) are rapidly progressive, nearly uniformly fatal brain tumors. Proteomic analysis represents an opportunity for noninvasive GBM classification and biological understanding of treatment response.PurposeWe analyzed differen
Externí odkaz:
https://doaj.org/article/93549edfb71e4974b65dcc0d50801684
Autor:
Sunita Chopra, Uma Shankavaram, Michelle Bylicky, Juan Dalo, Kevin Scott, Molykutty J. Aryankalayil, C. Norman Coleman
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Recent and past research have highlighted the importance of the endothelium in the manifestation of radiation injury. Our primary focus is on medical triage and management following whole body or partial-body irradiation. Here we investigate
Externí odkaz:
https://doaj.org/article/0a71d507171040baaba5035ef44aef56
Autor:
Jared M. May, Uma Shankavaram, Michelle A. Bylicky, Sunita Chopra, Kevin Scott, Shannon Martello, Karla Thrall, Jim Axtelle, Naresh Menon, C. Norman Coleman, Molykutty J. Aryankalayil
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract In a mass radiation exposure, the healthcare system may rely on differential expression of miRNA to determine exposure and effectively allocate resources. To this end, miRNome analysis was performed on non-human primate serum after whole tho
Externí odkaz:
https://doaj.org/article/3d867539d00642e08915a7ae9623bf71
Autor:
Andra V. Krauze, Yingdong Zhao, Ming-Chung Li, Joanna Shih, Will Jiang, Erdal Tasci, Theresa Cooley Zgela, Mary Sproull, Megan Mackey, Uma Shankavaram, Philip Tofilon, Kevin Camphausen
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1499 (2023)
Background: Glioblastoma (GBM) is the most common brain tumor with an overall survival (OS) of less than 30% at two years. Valproic acid (VPA) demonstrated survival benefits documented in retrospective and prospective trials, when used in combination
Externí odkaz:
https://doaj.org/article/1107fa231d3f4bf78bbde3b7c8957b18
Autor:
Lindsay S. Rowe, Stephanie Harmon, Adam Horn, Uma Shankavaram, Soumyajit Roy, Holly Ning, Liza Lindenberg, Esther Mena, Deborah E. Citrin, Peter Choyke, Baris Turkbey
Publikováno v:
Radiation Oncology, Vol 16, Iss 1, Pp 1-11 (2021)
Abstract Background Prostate Membrane Specific Antigen (PSMA) positron emission tomography (PET) and multiparametric MRI (mpMRI) have shown high accuracy in identifying recurrent lesions after definitive treatment in prostate cancer (PCa). In this st
Externí odkaz:
https://doaj.org/article/5a749152890f4be28729d42440496803
Autor:
Maria Diaz Rosario, Harpreet Kaur, Erdal Tasci, Uma Shankavaram, Mary Sproull, Ying Zhuge, Kevin Camphausen, Andra Krauze
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1203 (2022)
Sex differences are increasingly being explored and reported in oncology, and glioma is no exception. As potentially meaningful sex differences are uncovered, existing gender-derived disparities mirror data generated in retrospective and prospective
Externí odkaz:
https://doaj.org/article/59d7c941555647129817f252a5c71ea0
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Purpose: There is a need to identify new biomarkers of radiation exposure both for use in the development of biodosimetry blood diagnostics for radiation exposure and for clinical use as markers of radiation injury. In the current study, a novel high
Externí odkaz:
https://doaj.org/article/6e86eb07147041bf8c475209d291ee5c