Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ulrike Uhrig"'
Autor:
Thijs C. J. Verheul, Nynke Gillemans, Kerstin Putzker, Rezin Majied, Tingyue Li, Memnia Vasiliou, Bert Eussen, Annelies deKlein, Wilfred F. J. vanIJcken, Emile van denAkker, Marieke vonLindern, Joe Lewis, Ulrike Uhrig, Yukio Nakamura, Thamar vanDijk, Sjaak Philipsen
Publikováno v:
HemaSphere, Vol 8, Iss 8, Pp n/a-n/a (2024)
Abstract Reactivation of fetal hemoglobin expression alleviates the symptoms associated with β‐globinopathies, severe hereditary diseases with significant global health implications due to their high morbidity and mortality rates. The symptoms eme
Externí odkaz:
https://doaj.org/article/91383f39a1e04393a0bac4fede53e49c
Autor:
Shixian Yan, Paul Curtis Schöpe, Joe Lewis, Kerstin Putzker, Ulrike Uhrig, Edgar Specker, Jens Peter von Kries, Peter Lindemann, Anahid Omran, Hector E. Sanchez-Ibarra, Anke Unger, Mia-Lisa Zischinsky, Bert Klebl, Wolfgang Walther, Marc Nazaré, Dennis Kobelt, Ulrike Stein
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115698- (2023)
Metastasis is directly linked to poor prognosis of cancer patients and warrants search for effective anti-metastatic drugs. MACC1 is a causal key molecule for metastasis. High MACC1 expression is prognostic for metastasis and poor survival. Here, we
Externí odkaz:
https://doaj.org/article/6858c7b995054e39a758cb5c3e16c24a
Autor:
Jana Samarin, Piotr Fabrowski, Roman Kurilov, Hana Nuskova, Johanna Hummel-Eisenbeiss, Hannelore Pink, Nan Li, Vivienn Weru, Hamed Alborzinia, Umut Yildiz, Laura Grob, Minerva Taubert, Marie Czech, Michael Morgen, Christina Brandstädter, Katja Becker, Lianghao Mao, Ashok Kumar Jayavelu, Angela Goncalves, Ulrike Uhrig, Jeanette Seiler, Yanhong Lyu, Sven Diederichs, Ursula Klingmüller, Martina Muckenthaler, Annette Kopp-Schneider, Aurelio Teleman, Aubry K. Miller, Nikolas Gunkel
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102639- (2023)
Despite a strong rationale for why cancer cells are susceptible to redox-targeting drugs, such drugs often face tumor resistance or dose-limiting toxicity in preclinical and clinical studies. An important reason is the lack of specific biomarkers to
Externí odkaz:
https://doaj.org/article/43f98fcf2a844645aeeecc65e57523ec
Autor:
Yan Shixian, Paul Schöpe, Joe Lewis, Kerstin Putzker, Ulrike Uhrig, Edgar Specker, Jens von Kries, Hector E. Sanchez-Ibarra, Anke Unger, Mia Zischinsky, Bert Klebl, Peter Lindemann, Wolfgang Walther, Marc Nazaré, Dennis Kobelt, Ulrike Stein
Publikováno v:
Cancer Research. 83:2471-2471
Cancer metastasis is the most lethal attribute of cancer, frequently caused by insufficient therapies and limited therapy options. Novel compounds able to interfere with metastasis formation are therefore of tremendous interest. Colorectal Cancer (CR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a502bb9278ae03b11704185cee9d4c0
https://doi.org/10.1158/1538-7445.am2023-2471
https://doi.org/10.1158/1538-7445.am2023-2471
Autor:
Raphael R. Steimbach, Corey J. Herbst-Gervasoni, Severin Lechner, Tracy Murray Stewart, Glynis Klinke, Johannes Ridinger, Magalie N. E. Géraldy, Gergely Tihanyi, Jackson R. Foley, Ulrike Uhrig, Bernhard Kuster, Gernot Poschet, Robert A. Casero, Guillaume Médard, Ina Oehme, David W. Christianson, Nikolas Gunkel, Aubry K. Miller
We report the first well-characterized selective chemical probe for histone deacetylase 10 (HDAC10) with unprecedented selectivity over other HDAC isozymes. HDAC10 deacetylates polyamines and has a distinct substrate specificity, making it unique amo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b316efac4b7a20ac0237e7b99abdde28
https://doi.org/10.26434/chemrxiv-2021-37shs-v2
https://doi.org/10.26434/chemrxiv-2021-37shs-v2
Autor:
Miriam Fontanillo, Malgorzata Trebacz, Christopher D. Reinkemeier, Daniela Avilés Huerta, Ulrike Uhrig, Peter Sehr, Maja Köhn
Publikováno v:
Bioorganicmedicinal chemistry. 65
PP1 is a major phosphoserine/threonine-specific phosphatase that is involved in diseases such as heart insufficiency and diabetes. PP1-disrupting peptides (PDPs) are selective modulators of PP1 activity that release its catalytic subunit, which then
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04bb31dc010a110db24868a5a6a89701
https://pubmed.ncbi.nlm.nih.gov/35525109
https://pubmed.ncbi.nlm.nih.gov/35525109
Autor:
Paul Curtis Schöpe, Shixian Yan, Dennis Kobelt, Joe Lewis, Kerstin Putzker, Ulrike Uhrig, Edgar Specker, Jens Peter von Kries, Mathias Dahlmann, Hector E Sanchez-Ibarra, Anke Unger, Mia-Lisa Zischinsky, Bert Klebl, Peter Lindemann, Wolfgang Walther, Marc Nazaré, Ulrike Stein
Publikováno v:
Cancer Research. 83:A039-A039
The leading cause of cancer related deaths is the formation of metastasis, frequently caused by insufficient therapies and limited therapy options. Novel compounds able to interfere with metastasis formation are therefore of tremendous interest. Colo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c6f2bd9f7dfece71e36cb6b4e2ca2cd
https://doi.org/10.1158/1538-7445.metastasis22-a039
https://doi.org/10.1158/1538-7445.metastasis22-a039
Autor:
Jochen Reinstein, Jana Tünnermann, Guillaume Gotthard, Nicole Mertes, Stefanie Kühn, Ulrike Uhrig, Lin Xue, Kai Johnsson, Timo Tänzer, Jonas Wilhelm, Julien Hiblot, Miroslaw Tarnawski, Julie Karpenko
Publikováno v:
Biochemistry
Biochemistry, 60 (33)
'Biochemistry ', vol: 60, pages: 2560-2575 (2021)
Biochemistry, 60 (33)
'Biochemistry ', vol: 60, pages: 2560-2575 (2021)
The self-labeling protein tags (SLPs) HaloTag7, SNAP-tag, and CLIP-tag allow the covalent labeling of fusion proteins with synthetic molecules for applications in bioimaging and biotechnology. To guide the selection of an SLP-substrate pair and provi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62fa6e0f2af2cc4816d5b179c10588e
https://hdl.handle.net/21.11116/0000-0009-46B3-E21.11116/0000-0009-46B4-D21.11116/0000-0009-46B5-C21.11116/0000-0008-FCD2-F
https://hdl.handle.net/21.11116/0000-0009-46B3-E21.11116/0000-0009-46B4-D21.11116/0000-0009-46B5-C21.11116/0000-0008-FCD2-F
Autor:
Martin Lange, Erik Schulz, Mario Huerta, Mona Blatter, Ali Nowrouzi, Bernhard Kuster, Ulrike Uhrig, Karin Laaber, Axel Benner, Hanno Glimm, Claudia R. Ball, Sina Kreth, Dominik Mumberg, Kerstin Putzker, Friederike Herbst, Joerg Weiske, Hannes Hahne, Sarah Johannes, Gerhard Siemeister, Frank Westermann, Andrea Haegebarth, Martina K. Zowada, Gabriele Stoehr, Simon Holton, Paula L Codo, Joe Lewis, Sebastian M. Dieter, Ulrike Scheib, Lena-Marit Toepper, Sylvia Martin, Christine Siegl, Anna L. Ostermann-Parucha
Summary Novel treatment options for metastatic colorectal cancer (CRC) are urgently needed to improve patient outcome. Here, we screen a library of non-characterized small molecules against a heterogeneous collection of patient-derived CRC spheroids.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a410f992a87b35fec1505c6f97a79632
https://mediatum.ub.tum.de/doc/1652086/document.pdf
https://mediatum.ub.tum.de/doc/1652086/document.pdf
Autor:
Mareike Grotwinkel, Nikolai Hentze, Sabine Wegehingel, Ulrike Uhrig, Eleni Dimou, David W. Will, Walter Nickel, Matthias P. Mayer, Hans-Michael Müller, Peter Sehr, Julia P. Steringer, Giuseppe La Venuta, Joe Lewis
Publikováno v:
Journal of Biological Chemistry. 291:17787-17803
Fibroblast growth factor 2 (FGF2) is a potent mitogen promoting both tumor cell survival and tumor-induced angiogenesis. It is secreted by an unconventional secretory mechanism that is based upon direct translocation across the plasma membrane. Key s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9090e59030196207961d1718e02770d
https://doi.org/10.1074/jbc.m116.729384
https://doi.org/10.1074/jbc.m116.729384