Výsledky vyhledávání - "Ulrike Spohr"

The syntheses of 6-C-alkyl derivatives of methyl α-isomaltoside for a study of the mechanism of hydrolysis by amyloglucosidase

Autor: Ulrike Spohr, Nghia Le, Chang-Chun Ling, Raymond U. Lemieux

Publikováno v: Canadian Journal of Chemistry. 79:238-255

The epimeric (6aR)- and (6aS)-C-alkyl (methyl, ethyl and isopropyl) derivatives of methyl α-isomaltoside (1) were synthesized in order to examine the effects of introducing alkyl groups of increasing bulk on the rate of catalysis for the hydrolysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89a1ddf86daa4b85ffe6fdc5f8ddc1a3
https://doi.org/10.1139/v01-005

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Chemical mapping of the active site of the glucoamylase ofAspergillus niger

Autor: Dale R. Cameron, Raymond U. Lemieux, Birte Svensson, Torben P. Frandsen, Monica M. Palcic, Mimi Bach, Bjarne Stoffer, Ulrike Spohr

Publikováno v: Canadian Journal of Chemistry. 74:319-335

A recently developed technique for the probing of the combining sites of lectins and antibodies, to establish the structure of the epitope that is involved in the binding of an oligosaccharide, is used to study the binding of methyl α-isomaltoside b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef5c6bfbe1da960603a426ff162a0cf2
https://doi.org/10.1139/v96-036

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Molecular recognition XIII. The binding of the H-type 2 human blood group determinant by a winged bean (Psophocarpus tetragonolobus) acidic lectin

Autor: Raymond U. Lemieux, Shreeta Acharya, Ulrike Spohr, Ming-Hui Du, Avadhesha Surolia

Publikováno v: Canadian Journal of Chemistry. 72:158-163

The winged bean acidic lectin (WBA II) binds the H-type 2 human blood group related trisaccharide (α-L-Fuc-(1c → 2b)-β-D-Gal-(1b → 4a)-β-D-GlcNAc-OMe, 1). Interactions that importantly contribute to the specificity of the complex formation are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2ccba3a42aeb35623557f17b036ab03
https://doi.org/10.1139/v94-024

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Inhibitors of endo-α-mannosidase. Part III. Congeners of 1-deoxy-3-O-(α-D-glucopyranosyl)-mannojirimycin modified in the glucose unit

Autor: Mimi Bach, Ulrike Spohr

Publikováno v: Canadian Journal of Chemistry. 71:1943-1954

The syntheses of congeners of 1-deoxy-3-O-(α-D-glucopyranosyl)-mannojirimycin (1), a strong inhibitor of the glycoprotein-processing endo-mannosidase, are described. The chemical modifications of 1 involved all monodeoxy-genations and mono-O-methyla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37f92dba43e3485d514359ff3dea15c3
https://doi.org/10.1139/v93-241

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Inhibitors of endo-α-mannosidase. Part I. Derivatives of 3-O-(α-D-glucopyranosyl)-D-mannopyranose

Autor: Ulrike Spohr, Mimi Bach, Robert G. Spiro

Publikováno v: Canadian Journal of Chemistry. 71:1919-1927

Golgi membrane endo-α-D-mannosidase releases the disaccharide αDGlc(1 → 3)DMan (34) from the GlcMan9GlcNAc2 oligosaccharide of immature N-linked glycoproteins. To convert the hydrolysis product 34 into a potent inhibitor of the enzyme, chemical m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb19d3b3ede3c1f3bcf2ab23a92a2a23
https://doi.org/10.1139/v93-239

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Inhibitors of endo-α-mannosidase. Part II. 1-Deoxy-3-O-(α-D-glucopyranosyl)-mannojirimycin and congeners modified in the mannojirimycin unit

Autor: Ulrike Spohr, Robert G. Spiro, Mimi Bach

Publikováno v: Canadian Journal of Chemistry. 71:1928-1942

The syntheses of 1-deoxy-3-O-(α-D-glucopyranosyl)-mannojirimycin (9) and its 2-deoxy, 2-O-methyl, 4-deoxy, 4-O-methyl, 6-deoxy, 6-O-methyl, N-methyl, and N-propyl congeners are described. Since 9 was previously shown to effectively inhibit endo-α-D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4821f1fdd644bd1644ac7f4e9bc6180
https://doi.org/10.1139/v93-240

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Molecular recognition XII. The binding of the H human blood group determinants and congeners by a lectin of Galactiatenuiflora

Autor: Rémy Cromer, Raymond U. Lemieux, Deveshwari P. Khare, Jacques LePendu, Ulrike Spohr

Publikováno v: Canadian Journal of Chemistry. 70:1511-1530

The H-type 2 human blood group-related trisaccharide (α-L-Fuc-(1c → 2b)-β-D-Gal-(1b → 4a)-β-D-GlcNAc-OMe (52)) is bound by the anti-H lectin of Galactiatenuiflora very differently than by the lectin I of Ulexeuropaeus. The reason why the Galac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::076ad27391f5e16bc16f202eac03b35a
https://doi.org/10.1139/v92-187

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Molecular recognition IX. The synthesis of the H-type 2 human blood group determinant and congeners modified at the 6-position of the N-acetylglucosamine unit

Autor: Ulrike Spohr, Raymond U. Lemieux, Eva Petrakova

Publikováno v: Canadian Journal of Chemistry. 70:233-240

The synthesis of the methyl glycosides of the H-type 2 human blood group determinant (α-L-Fuc-(1c → 2b)-β-D-Gal-(1b → 4a)-β-D-GlcNAc-OMe) and its 6a-deoxy, 6a-O-methyl, 6a-chloro-6a-deoxy, 6a-deoxy-6a-fluoro, 6a-amino-6a-deoxy, 6a-acetamido-6a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d9d1f9d6fce1b0f19f075c43b41daab
https://doi.org/10.1139/v92-034

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