Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ulrike Obermüller"'
Autor:
Christine Rother, Ruth E. Uhlmann, Stephan A. Müller, Juliane Schelle, Angelos Skodras, Ulrike Obermüller, Lisa M. Häsler, Marius Lambert, Frank Baumann, Ying Xu, Carina Bergmann, Giulia Salvadori, Maarten Loos, Irena Brzak, Derya Shimshek, Ulf Neumann, Dominantly Inherited Alzheimer Network, Lary C. Walker, Stephanie A. Schultz, Jasmeer P. Chhatwal, Stephan A. Kaeser, Stefan F. Lichtenthaler, Matthias Staufenbiel, Mathias Jucker
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The poor correlation between brain Aβ deposition and clinical symptoms in Alzheimer´s disease remains puzzling. Here, the authors show a temporal dissociation of Aβ deposition and neurodegeneration.
Externí odkaz:
https://doaj.org/article/c331575d738c441aa6d10bc637786581
Autor:
Gaye Tanriöver, Mehtap Bacioglu, Manuel Schweighauser, Jasmin Mahler, Bettina M. Wegenast-Braun, Angelos Skodras, Ulrike Obermüller, Melanie Barth, Deborah Kronenberg-Versteeg, K. Peter R. Nilsson, Derya R. Shimshek, Philipp J. Kahle, Yvonne S. Eisele, Mathias Jucker
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-11 (2020)
Abstract Alpha-synucleinopathies are a group of progressive neurodegenerative disorders, characterized by intracellular deposits of aggregated α-synuclein (αS). The clinical heterogeneity of these diseases is thought to be attributed to conformers
Externí odkaz:
https://doaj.org/article/d21f1979370c47cc9fcbb8419a787497
Autor:
Luis F Maia, Stephan A Kaeser, Julia Reichwald, Marius Lambert, Ulrike Obermüller, Juliane Schelle, Jörg Odenthal, Peter Martus, Matthias Staufenbiel, Mathias Jucker
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 7, Pp 895-903 (2015)
Abstract Abnormalities in brains of Alzheimer's disease (AD) patients are thought to start long before the first clinical symptoms emerge. The identification of affected individuals at this ‘preclinical AD’ stage relies on biomarkers such as decr
Externí odkaz:
https://doaj.org/article/c3edd8a53ff64426911680902d63c946
Autor:
Jessica Wagner, Karoline Degenhardt, Marleen Veit, Nikolaos Louros, Katerina Konstantoulea, Angelos Skodras, Katleen Wild, Ping Liu, Ulrike Obermüller, Vikas Bansal, Anupriya Dalmia, Lisa M. Häsler, Marius Lambert, Matthias De Vleeschouwer, Hannah A. Davies, Jillian Madine, Deborah Kronenberg-Versteeg, Regina Feederle, Domenico Del Turco, K. Peter R. Nilsson, Tammaryn Lashley, Thomas Deller, Marla Gearing, Lary C. Walker, Peter Heutink, Frederic Rousseau, Joost Schymkowitz, Mathias Jucker, Jonas J. Neher
Publikováno v:
Nature 612(7938), 123-131 (2022). doi:10.1038/s41586-022-05440-3
Nature 612, 123-131 (2022)
Nature 612, 123-131 (2022)
Aggregates of medin amyloid (a fragment of the protein MFG-E8, also known as lactadherin) are found in the vasculature of almost all humans over 50 years of age1,2, making it the most common amyloid currently known. We recently reported that medin al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c91db7a3628281af11389c3f665f1a
https://doi.org/10.1038/s41586-022-05440-3
https://doi.org/10.1038/s41586-022-05440-3
Autor:
Timo Eninger, Stephan A. Müller, Mehtap Bacioglu, Manuel Schweighauser, Marius Lambert, Luis F. Maia, Jonas J. Neher, Sarah M. Hornfeck, Ulrike Obermüller, Gernot Kleinberger, Christian Haass, Philipp J. Kahle, Matthias Staufenbiel, Lingyan Ping, Duc M. Duong, Allan I. Levey, Nicholas T. Seyfried, Stefan F. Lichtenthaler, Mathias Jucker, Stephan A. Kaeser
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America 119(24), e2119804119 (2022). doi:10.1073/pnas.2119804119
Single-cell transcriptomics has revealed specific glial activation states associated with the pathogenesis of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. While these findings may eventually lead to new therapeutic opp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba441cb791cf307fa6f069cd0a53bef0
https://pubmed.ncbi.nlm.nih.gov/35666874
https://pubmed.ncbi.nlm.nih.gov/35666874
Autor:
Angelos Skodras, Anna Julia Koppelmann, Jillian Madine, Katleen Wild, Lisa M. Haesler, Felix von Zweydorf, Karoline Degenhardt, Rusheka Maxwell, Philipp J. Kahle, Domenico Del Turco, Ulrike Obermüller, Thomas Deller, Mathias Jucker, Christian Johannes Gloeckner, Jonas J. Neher, Hannah A. Davies, Jessica Wagner, Carola Rotermund
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed12e13ec20144b999c39ce255a565b3
https://doi.org/10.1002/alz.042861
https://doi.org/10.1002/alz.042861
Autor:
Ulrike Obermüller, Mathias Jucker, Deborah Kronenberg-Versteeg, Mehtap Bacioglu, Melanie Barth, Angelos Skodras, Jasmin Mahler, Gaye Tanriöver, Philipp J. Kahle, Yvonne S. Eisele, Manuel Schweighauser, Derya R. Shimshek, Bettina M. Wegenast-Braun, K. Peter R. Nilsson
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-11 (2020)
Acta Neuropathologica Communications 8(1), 133 (2020). doi:10.1186/s40478-020-00993-8
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-11 (2020)
Acta Neuropathologica Communications 8(1), 133 (2020). doi:10.1186/s40478-020-00993-8
Alpha-synucleinopathies are a group of progressive neurodegenerative disorders, characterized by intracellular deposits of aggregated alpha-synuclein (alpha S). The clinical heterogeneity of these diseases is thought to be attributed to conformers (o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6290ce4a5391f9a561c882cc5dbce98e
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-169230
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-169230
Autor:
Paul H. Weinreb, Lary C. Walker, Matthias Staufenbiel, Ruth E. Uhlmann, Rawaa Al-Shaana, Emily M. Ullrich Gavilanes, Søren Christensen, Frank Baumann, Ulrike Obermüller, Stephan A. Kaeser, Fredrik Kartberg, Mathias Jucker, Angelos Skodras, Jay Rasmussen, Holger Cynis, Lan Ye, Anika Buehler, Fang Qian, Carina Bergmann, Juliane Schelle, Sarah K. Fritschi, Thierry Bussiere, Jens-Ulrich Rahfeld, Christine Rother, Natalie Beschorner, Jeffrey B. Stavenhagen
Publikováno v:
Nat Neurosci
Nature neuroscience 23(12), 1580-1588 (2020). doi:10.1038/s41593-020-00737-w
Nature neuroscience 23(12), 1580-1588 (2020). doi:10.1038/s41593-020-00737-w
Amyloid-β (Aβ) deposits are a relatively late consequence of Aβ aggregation in Alzheimer's disease. When pathogenic Aβ seeds begin to form, propagate and spread is not known, nor are they biochemically defined. We tested various antibodies for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304ff0cfb27901cbd3f5fac431ae6943
https://publica.fraunhofer.de/handle/publica/269747
https://publica.fraunhofer.de/handle/publica/269747
Autor:
Sarah K. Fritschi, Matthias Staufenbiel, Lary C. Walker, Anika Buehler, Ulrike Obermüller, Juliane Schelle, Christine Rother, Ruth E. Uhlmann, Mathias Jucker, Jay Rasmussen, Fredrik Kartberg, Stephan A. Kaeser, Jeffrey B. Stavenhagen, Emily M. Ullrich-Gavilanes, Holger Cynis, Søren Christensen, Frank Baumann
Publikováno v:
Alzheimer's & Dementia. 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::784dcbf4f6976d6ea696757c7107e324
https://doi.org/10.1016/j.jalz.2019.09.054
https://doi.org/10.1016/j.jalz.2019.09.054
Autor:
Audun Konsmo, Bettina M. Wegenast-Braun, Mikael Lindgren, Jun Zhang, Per Hammarström, Xiongyu Wu, Sofie Nyström, Alexander Sandberg, Peter Konradsson, Ulrike Obermüller
Publikováno v:
Journal of medicinal chemistry 62(4), 2038-2048 (2019). doi:10.1021/acs.jmedchem.8b01681
A fluorescent bis-styryl-benzothiadiazole (BTD) with carboxylic acid functional groups (X-34/Congo red analogue) showed lower binding affinity toward Aβ1-42 and Aβ1-40 fibrils than its neutral analogue. Hence, variable patterns of neutral OH-substi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad989f8b15360e5f7a1f057e416cea1
https://pubmed.ncbi.nlm.nih.gov/30707834
https://pubmed.ncbi.nlm.nih.gov/30707834