Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ulrike Nowe"'
Autor:
Gerd Dannhardt, Sabine Maehrlein, Godehard Krämer, Ulrike Nowe, Werner Kiefer, Bernd L. Fiebich
Publikováno v:
European Journal of Medicinal Chemistry. 35:499-510
Aroyl- and thiophene-substituted pyrrole derivatives have been synthesized as a new class of COX-1/COX-2 inhibitors. The inhibition of COX-1 was evaluated in a biological system using bovine PMNLs as the enzyme source, whereas LPS-stimulated human mo
Publikováno v:
Journal f�r Praktische Chemie/Chemiker-Zeitung. 340:256-263
The synthesis and stereochemical characteristics of pyrrolidino-, isoquinolino- and indolo-enaminones 2–11 are reported. The inhibition of cyclooxygenase was determined in a bovine thrombocyte intact cell assay and that of 5-lipoxygenase using inta
Publikováno v:
Archiv der Pharmazie. 330:74-82
The pyrrolidino enaminones, with the carboxylic acid chain fixed at the nitrogen, inhibit cyclooxygenase more potently or selectively than 5-lipoxygenase. According to the structure-activity relationships discussed the potency depends significantly o
Publikováno v:
Archiv der Pharmazie. 329:301-310
The delay of onset of irritation phenomena at the chorioallantoic membrane of incubated hen's eggs, a parameter for anti-inflammatory activity, was determined for the pharmaceutical substances diclofenac, flufenamic acid, ibuprofen, indomethacin, ket
Publikováno v:
Archiv der Pharmazie. 328:681-686
The pyrrolizinyl substituted acrylic acid derivatives represent another class of dual and selective inhibitors of cyclooxygenase and 5-lipoxygenase. By modifying their substitution pattern at the phenyl moiety of C-6 the balance between the activity
Autor:
G. Paul Savage, Anna Bezos, Satish Chand, Holger Ulbrich, Christopher R. Parish, Gerd Dannhardt, Werner Kiefer, Martin G. Banwell, Ulrike Nowe
Publikováno v:
Org. Biomol. Chem.. 1:2427-2429
Treatment of an equimolar mixture of stilbene 7 and cinnamyl alcohol 8 with silver carbonate in acetone–benzene afforded a ca. 2 : 1 : 2 : 1 mixture of the stilbenolignan (±)-aiphanol (1) and congeners 2–4 each of which show significant anti-ang
Publikováno v:
ChemInform. 27
Publikováno v:
ChemInform. 28
Publikováno v:
ChemInform. 28
Publikováno v:
ChemInform. 29