Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Ulrike Novak"'
Publikováno v:
Journal of Cell Science. 119:3296-3305
ADAM22 is one of three catalytically inactive ADAM family members highly expressed in the brain. ADAM22 has numerous splice variants, all with considerable cytoplasmic tails of up to 148 amino acids. ADAM22 can act to inhibit cell proliferation, howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d50e2d9afcfd7515f95bcc97ccfff03
https://doi.org/10.1242/jcs.03065
https://doi.org/10.1242/jcs.03065
Publikováno v:
Neurosurgery. 58:179-186
OBJECTIVE: To study the expression and function of the brain-specific proteinase deficient disintegrins, ADAM11 and ADAM22 (a disintegrin and metalloproteinase). METHODS: Specimens of low- and high-grade gliomas and normal brain were analyzed for ADA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1f1bc5115eadcf34162fda091282ea
https://doi.org/10.1227/01.neu.0000192363.84287.8b
https://doi.org/10.1227/01.neu.0000192363.84287.8b
Autor:
David M. Ashley, Andrea Muscat, Christopher D. Riffkin, Andrew H. Kaye, Christine J. Hawkins, Ulrike Novak, Melissa J. Knight
Publikováno v:
Cancer. 104:1487-1496
BACKGROUND Better treatments are required urgently for patients with malignant glioma, which currently is incurable. Death ligands, such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), may offer promise for the treatment high-grad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3bbec461d15741281746e6fcdbf937
https://doi.org/10.1002/cncr.21323
https://doi.org/10.1002/cncr.21323
Publikováno v:
Neurosurgery. 50:1311-1318
OBJECTIVE: The interactions of CD44 with hyaluronan are thought to be crucial for tumor cell attachment to the extracellular matrix, migration, and invasion. For migration to occur, however, the interactions between hyaluronan and cell surface recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ace5fac8ba5e10557e04525ca877e8
https://doi.org/10.1227/00006123-200206000-00023
https://doi.org/10.1227/00006123-200206000-00023
Publikováno v:
Journal of Clinical Neuroscience. 9:282-288
Cell contact with the extracellular matrix component, hyaluronan, plays a pivotal role in glioma cell invasion and proliferation. Although it is well established that glioma cells can bind hyaluronan to their surface via the expression of CD44, the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde7d28f4f48d0ef71891aea5b9d2666
https://doi.org/10.1054/jocn.2001.1063
https://doi.org/10.1054/jocn.2001.1063
Autor:
Ulrike Novak, Ian P. Wicks, Ian K. Campbell, David M. Tarlinton, Fiona J. Clay, Paul Waring, Melissa Inglese, Shisan Bao, Joan K. Heath, Matthias Ernst, Warren S. Alexander, Ashley R. Dunn
Publikováno v:
The Journal of Experimental Medicine
The receptor subunit gp130 transduces multiple cell type-specific activities of the leukemia inhibitory factor (LIF)/interleukin (IL)-6 family of cytokines through the signal transducer and activator of transcription (STAT) and src homology 2 domain-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21683f0e8a2b9d8bf45299bb94f3ebd7
https://doi.org/10.1084/jem.194.2.189
https://doi.org/10.1084/jem.194.2.189
Publikováno v:
Journal of Clinical Neuroscience. 8:106-111
The growth of cells is regulated by growth factors which act as ligands of specific receptors on the cell surface. Thus, ligands binding to the receptors activate a series of cellular responses leading to proliferation. In various pathological condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb60b74517e3b5d6851e8dbfeaaab0c
https://doi.org/10.1054/jocn.2000.0799
https://doi.org/10.1054/jocn.2000.0799
Publikováno v:
Journal of Clinical Neuroscience. 7:137-140
We studied the expression of the hyaluronan receptor protein CD44 in the mouse brain in response to stab injuries. CD44 expression was strongly activated in the area surrounding the injury within 2 days and then persisted for over 2 months. The expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd54ded4ccb94e4f3b231749ae3f5a9
https://doi.org/10.1054/jocn.1999.0187
https://doi.org/10.1054/jocn.1999.0187
Publikováno v:
Journal of Biological Chemistry. 274:9729-9737
Cell type-specific responses to the leukemia inhibitory factor (LIF)/interleukin 6 cytokine family are mediated by dimerization of the LIF receptor alpha-chain (LIFRalpha) with the signal transducer gp130 or of two gp130 molecules followed by activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::798047016c2d7bf0bdcc1f8762658af9
https://doi.org/10.1074/jbc.274.14.9729
https://doi.org/10.1074/jbc.274.14.9729
Publikováno v:
Journal of Biological Chemistry. 271:18350-18354
Colony-stimulating factor (CSF-1) activates several members belonging to the STAT (signal transducers and activators of transcription) family of transcription factors. We investigated the DNA binding complexes activated by CSF-1 in several cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb031f07c1c9edcf6bc7b3249c3b0063
https://doi.org/10.1074/jbc.271.31.18350
https://doi.org/10.1074/jbc.271.31.18350