Výsledky vyhledávání - "Ulrike Maschke"

Soluble (pro)renin receptor in preeclampsia and diabetic pregnancies

Autor: Anne Cathrine Staff, Meryam Sugulle, Dominik N Mueller, Ulrike Maschke, Ralf Dechend, Florian Herse, Harald Heidecke, A.H. Jan Danser

Publikováno v: Journal of the American Society of Hypertension, 11(10), 644-652. Elsevier Ireland Ltd

Women with preexisting or gestational diabetes mellitus have an increased risk for developing preeclampsia. Diabetes and pregnancy are both characterized by very high prorenin levels and renin-angiotensin system activation. Prorenin bound to the (pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902c8c99d626f43e843b9bf241800135
https://pure.eur.nl/en/publications/33c2b6a6-b9c8-481c-87e7-0fc011cab16f

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Prorenin Receptor Is Essential for Podocyte Autophagy and Survival

Publikováno v: Journal of the American Society of Nephrology. 22:2193-2202

The prorenin receptor (PRR) is highly expressed in podocytes, but its role in the maintenance of podocyte function is unknown. Here we generated podocyte-specific PRR-knockout mice and found that these animals died between 2 to 3 wk after birth. With

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a108210759409f136f4558cd99baa4f9
https://doi.org/10.1681/asn.2011020200

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Lack of cardiac fibrosis in a new model of high prorenin hyperaldosteronism

Autor: Torsten Schlüter, Ulrike Maschke, Norbert Hosten, Andreas Beineke, John J. Mullins, Barbara S. Peters, Jörg Peters, Rainer Rettig, Thomas Riegel

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology

The aim of the present study was to test the hypothesis that elevation of prorenin in plasma is sufficient to induce cardiac fibrosis. Normotensive cyp1a1 ren-2 transgenic rats with normal plasma prorenin and aldosterone levels were given 0.125% indo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6e995c2aff32a71317f3d2946abb6d
https://doi.org/10.1152/ajpheart.01135.2008

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Prorenin and Renin-Induced Extracellular Signal-Regulated Kinase 1/2 Activation in Monocytes Is Not Blocked by Aliskiren or the Handle-Region Peptide

Autor: Friedrich C. Luft, Anette Fiebeler, A.H. Jan Danser, Sandra Feldt, Maren Wellner, Geneviève Nguyen, Aurelie Contrepas, Wendy W. Batenburg, Michael Bader, Ulrike Maschke, Istvan Mazak, Heda Kvakan, Céline Burcklé, Ralf Dechend, Dominik N. Müller

Publikováno v: Hypertension, 51(3), 682-688. Lippincott Williams & Wilkins

The recently cloned (pro)renin receptor [(P)RR] mediates renin-stimulated cellular effects by activating mitogen-activated protein kinases and promotes nonproteolytic prorenin activation. In vivo, (P)RR is said to be blocked with a peptide consisting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e091dadeb9c146163d67205d5448611
https://doi.org/10.1161/hypertensionaha.107.101444

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New role for the (pro)renin receptor in T-cell development

Autor: Katrina J. Binger, Mark D. Wright, Markus Kleinewietfeld, Arndt Manzel, Ralf A. Linker, Sabrina Geisberger, Genevieve Nguyen, Ann P. Chidgey, Ulrike Maschke, Oliver Daumke, Dominik N. Müller, Ralf Dechend, Matthias Gebhardt

Publikováno v: Blood. 126(4)

The (pro)renin receptor (PRR) was originally thought to be important for regulating blood pressure via the renin-angiotensin system. However, it is now emerging that PRR has instead a generic role in cellular development. Here, we have specifically d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff1be430172a122a9937f596a5fb4798
https://pubmed.ncbi.nlm.nih.gov/26063165

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Alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism are both ATP1A3-related disorders

Autor: Peter Nürnberg, Ulrike Maschke, Holger Thiele, Jutta Gärtner, Hendrik Rosewich, Andreas Ohlenbusch, Peter Frommolt, Knut Brockmann

Publikováno v: Molecular and Cellular Pediatrics

Alternating hemiplegia of childhood (AHC) was first described as a distinctive disease in 1971 [1]. The disease is characterised by early-onset episodes of hemiplegia, dystonia, numerous paroxysmal symptoms, and developmental impairment [2]. Almost a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6aadc2dd7372fae92257ffe6e17db22
http://europepmc.org/articles/PMC4715209

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Heterozygous de-novo mutations in ATP1A3 in patients with alternating hemiplegia of childhood: a whole-exome sequencing gene-identification study

Autor: Peter Frommolt, Peter Nürnberg, Jutta Gärtner, Ulrike Maschke, Knut Brockmann, Andreas Ohlenbusch, Janine Altmüller, Hendrik Rosewich, Holger Thiele, Birgit Zirn, Friedrich Ebinger, Hartmut Siemes

Summary Background Alternating hemiplegia of childhood (AHC) is a rare neurological disorder characterised by early-onset episodes of hemiplegia, dystonia, various paroxysmal symptoms, and developmental impairment. Almost all cases of AHC are sporadi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f037dfab9b82697c99a01a32b7b4232
http://resolver.sub.uni-goettingen.de/purl?gs-1/11305

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Renin- and prorenin-induced effects in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor: does (pro)renin-(pro)renin receptor interaction actually occur?

Autor: A.H. Jan Danser, Frank P.J. Leijten, Dominik N. Müller, Wendy W. Batenburg, Xifeng Lu, Ulrike Maschke

Publikováno v: Hypertension, 58(6), 1111-1119. Lippincott Williams & Wilkins

Renin/prorenin binding to the (pro)renin receptor ([P]RR) results in direct (angiotensin-independent) second-messenger activation in vitro, whereas in vivo studies in rodents overexpressing prorenin (approximate to 400-fold) or the (P)RR do not suppo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74f968563aaa21dad0efc43f95dea7f
https://pubmed.ncbi.nlm.nih.gov/22025376

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The Putative (Pro)renin Receptor Blocker HRP Fails to Prevent (Pro)renin Signaling

Autor: Ralf Dechend, Ulrike Maschke, Sandra Feldt, Friedrich C. Luft, Dominik N. Müller

The prorenin/renin receptor is a recently discovered component of the renin-angiotensin system. The effects of aliskiren, a direct inhibitor of human renin, were compared with the handle region decoy peptide (HRP), which blocks the prorenin/renin rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de00525cf95174d3acc713d4959f0b2
https://europepmc.org/articles/PMC2390971/

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The (pro)renin receptor and the mystic HRP - Is there a role in cardiovascular disease?

Autor: Ulrike Maschke, Dominik N. Müller

Publikováno v: Scopus-Elsevier

In 2002, Nguyen et al. cloned the (pro)renin receptor ((P)RR). Two years later, Suzuki, Ichihara and colleagues provided a concept to inhibit the (P)RR through HRP. This decapeptide mimics a sequence of the prorenin prosegment and functions thereby a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea367dbd04f051e8f276c72b69fadb1
http://www.scopus.com/inward/record.url?eid=2-s2.0-77957370766&partnerID=MN8TOARS

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