Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ulrike MacDonald"'
Autor:
Thomas A. Russo, Ulrike MacDonald, Sidra Hassan, Ellie Camanzo, Francois LeBreton, Brendan Corey, Patrick McGann
Publikováno v:
mSphere, Vol 6, Iss 2 (2021)
The pathogenic potential of hvKp strains is primarily mediated by a large virulence plasmid. The minimal set of genes required for the full expression of the hypervirulent phenotype is undefined.
Externí odkaz:
https://doaj.org/article/c51a1ad2549b4bc7be6afba76717908b
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Acinetobacter baumannii is a problematic pathogen due to its common expression of extensive drug resistance (XDR) and ability to survive in the healthcare environment. These characteristics are mediated, in part, by the signal transduction system Bfm
Externí odkaz:
https://doaj.org/article/9229fb22507341fead1b8da32e26f34f
Autor:
Thomas A. Russo, Ulrike MacDonald
Publikováno v:
mSphere, Vol 5, Iss 1 (2020)
ABSTRACT Hypervirulent Klebsiella pneumoniae (hvKp) is an emerging pathogen of increasing concern due to its ability to cause serious organ and life-threatening infections in healthy individuals and its increasing acquisition of antimicrobial resista
Externí odkaz:
https://doaj.org/article/f5525bccdbaf46598571854b9c74de9e
Autor:
Thomas A. Russo, Akshay Manohar, Janet M. Beanan, Ruth Olson, Ulrike MacDonald, Jessica Graham, Timothy C. Umland
Publikováno v:
mSphere, Vol 1, Iss 3 (2016)
ABSTRACT Identification and validation is the first phase of target-based antimicrobial development. BfmR (RstA), a response regulator in a two-component signal transduction system (TCS) in Acinetobacter baumannii, is an intriguing potential antimicr
Externí odkaz:
https://doaj.org/article/0bbb530e852f461ea2681f39154ed515
Autor:
Timothy C. Umland, L. Wayne Schultz, Ulrike MacDonald, Janet M. Beanan, Ruth Olson, Thomas A. Russo
Publikováno v:
mBio, Vol 3, Iss 4 (2012)
ABSTRACT A critical feature of a potential antimicrobial target is the characteristic of being essential for growth and survival during host infection. For bacteria, genome-wide essentiality screens are usually performed on rich laboratory media. Thi
Externí odkaz:
https://doaj.org/article/491cd2e6833c4b1487eafbb994a6b2da
Autor:
Thomas A Russo, Alyssa S Shon, Janet M Beanan, Ruth Olson, Ulrike MacDonald, Alexander O Pomakov, Mark P Visitacion
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26734 (2011)
A new hypervirulent (hypermucoviscous) clinical variant of Klebsiella pneumoniae (hvKP) has emerged over the last decade. Our goal is to identify new mechanisms, which increase the virulence hvKP compared to "classic" K. pneumoniae (cKP).Various grow
Externí odkaz:
https://doaj.org/article/de434ad9491b4ef08ecdf87f45cd7749
Autor:
Lindsey R. Hall, Patrick McGann, Jason W. Bennett, Melissa J. Martin, Francois Lebreton, Giacinta Tordini, Ulrike MacDonald, Thomas A. Russo, Jean Denis Docquier, Katharina Schaufler, Brendan T. Jones, Rosslyn Maybank, Nils-Olaf Hübner, Jason Stam, Stefania Cresti, Emma G. Mills, Filomena Sannio, Marcello Valassina, Karsten Becker, Brendan W. Corey, Yoon I. Kwak, Maria Grazia Cusi
A protracted outbreak of New Delhi metallo-beta-lactamase (NDM)-producing carbapenem-resistant Klebsiella pneumoniae, started in Tuscany, Italy, in November 2018 and continued in 2020 and through 2021. To understand the regional emergence and transmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eef3e54b21f6af6dd965e2b1863db4fd
https://doi.org/10.1101/2021.06.02.446696
https://doi.org/10.1101/2021.06.02.446696
Autor:
Ruth Olson, Janet M. Beanan, Shun Xin Wang-Lin, Thomas A. Russo, Joseph P. Balthasar, Ulrike MacDonald
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 368:475-489
Acinetobacter baumannii has become a pathogen of increasing medical importance because of the emergence of multidrug-resistant strains and the high rate of mortality of infected patients. Promising animal study results have been reported recently wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::956d27ea6483c62a2c6c6ba4717c89fa
https://doi.org/10.1124/jpet.118.253617
https://doi.org/10.1124/jpet.118.253617
Autor:
Sidra Hassan, Patrick McGann, Ellie Camanzo, Brendan W. Corey, Thomas A. Russo, Ulrike MacDonald, Francois Lebreton
Publikováno v:
mSphere
mSphere, Vol 6, Iss 2 (2021)
mSphere, Vol 6, Iss 2 (2021)
Hypervirulent Klebsiella pneumoniae (hvKp) bacteria are more virulent than classical K. pneumoniae (cKp) with resultant differences in clinical manifestations and management. It is unclear whether all hvKp isolates share a similar pathogenic potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d396dd0668541a92aa594a7d5887b817
https://doi.org/10.1128/msphere.00045-21
https://doi.org/10.1128/msphere.00045-21
Autor:
Patrick McGann, Yoon I. Kwak, Ulrike MacDonald, Maria Grazia Cusi, Melissa J. Martin, Jason Stam, Francois Lebreton, Casey Harless, Giacinta Tordini, Emma G. Mills, Jean Denis Docquier, Stefania Cresti, Lindsey R. Hall, Karsten Becker, Rosslyn Maybank, Brendan W. Corey, Brendan T. Jones, Thomas A. Russo, Filomena Sannio, Jason W. Bennett, Katharina Schaufler, Marcello Valassina, Nils-Olaf Hübner
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Carbapenem-resistant Klebsiella pneumoniae belongs to the “critical-priority” tier of bacterial pathogens as identified by the World Health Organization. Emerging “high-risk” lineages are responsible for difficult-to-treat, hospi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b377839e5d79aa43c77a1fe92bfae13a
http://hdl.handle.net/11365/1193691
http://hdl.handle.net/11365/1193691