Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Ulrike Koehl"'
Autor:
Krasimira Aleksandrova, Jana Leise, Christoph Priesner, Murat Aktas, Michael Apel, Mario Assenmacher, Iris Bürger, Anne Richter, Pia Altefrohne, Christine Schubert, Astrid Holzinger, Markus Barden, Valerie Bezler, Michael von Bergwelt-Baildon, Peter Borchmann, Lilia Goudeva, Wolfgang Glienke, Lubomir Arseniev, Ruth Esser, Hinrich Abken, Ulrike Koehl
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionPoint-of-care (POC) manufacturing of chimeric antigen receptor (CAR) modified T cell has expanded rapidly over the last decade. In addition to the use of CD19 CAR T cells for hematological diseases, there is a growing interest in targetin
Externí odkaz:
https://doaj.org/article/f6589c518506495e91a9217ebb7da6b4
Autor:
Katharina Schindler, Katharina Eva Ruppel, Claudia Müller, Ulrike Koehl, Stephan Fricke, Dominik Schmiedel
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101328- (2024)
Chimeric antigen receptor (CAR) T cell therapies have demonstrated significant successes in treating cancer. Currently, there are six approved CAR T cell products available on the market that target different malignancies of the B cell lineage. Howev
Externí odkaz:
https://doaj.org/article/000c7fbba4b44affa398d8d0b90bac7c
Autor:
Nadine von Auw, Robert Serfling, Reni Kitte, Nadja Hilger, Chengkang Zhang, Clara Gebhardt, Anna Duenkel, Paul Franz, Ulrike Koehl, Stephan Fricke, U. Sandy Tretbar
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Process development for transferring lab-scale research workflows to automated manufacturing procedures is critical for chimeric antigen receptor (CAR)-T cell therapies. Therefore, the key factor for cell viability, expansion, modification,
Externí odkaz:
https://doaj.org/article/8b63763abf524441b380a6695312d24d
Autor:
Anja Grahnert, Sabine Seiffert, Kerstin Wenk, Dominik Schmiedel, Andreas Boldt, Vladan Vucinic, Maximilian Merz, Uwe Platzbecker, Christian Klemann, Ulrike Koehl, Maik Friedrich
Publikováno v:
Biomedicines, Vol 12, Iss 8, p 1641 (2024)
For the monitoring of chimeric antigen receptor (CAR) T-cell therapies, antigen-based CAR detection methods are usually applied. However, for each target-antigen, a separate detection system is required. Furthermore, when monitored CAR T-cells in the
Externí odkaz:
https://doaj.org/article/59aac0cc85b040fb8e4a0a875b373a9c
Autor:
Delphine Ammar, Inga Schapitz, Maik Luu, Michael Hudecek, Miriam Meyer, Timmothy Taps, Bernd Schröder, Zoltán Ivics, Carmen Sanges, Paul Franz, Ulrike Koehl, Helene Negre, Inez Johanna, Jacquelyn Awigena-Cook
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
To accelerate the development of Advanced Therapy Medicinal Products (ATMPs) for patients suffering from life-threatening cancer with limited therapeutic options, regulatory approaches need to be constantly reviewed, evaluated and adjusted, as necess
Externí odkaz:
https://doaj.org/article/5d384e6985d7461ba55323e181207b7d
Publikováno v:
RMD Open, Vol 9, Iss 4 (2023)
Autoimmune disorders occur when immune cells go wrong and attack the body’s own tissues. Currently, autoimmune disorders are largely treated by broad immunosuppressive agents and blocking antibodies, which can manage the diseases but often are not
Externí odkaz:
https://doaj.org/article/f23e0b3ee37445099126896b758290ec
Autor:
Ioana Sonya Ciulean, Joe Fischer, Andrea Quaiser, Christoph Bach, Hinrich Abken, Uta Sandy Tretbar, Stephan Fricke, Ulrike Koehl, Dominik Schmiedel, Thomas Grunwald
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Head and neck squamous cell carcinoma (HNSCC) is a major challenge for current therapies. CAR-T cells have shown promising results in blood cancers, however, their effectiveness against solid tumors remains a hurdle. Recently, CD44v6-directed CAR-T c
Externí odkaz:
https://doaj.org/article/044907c4e38c46f7a1a5c652befa4188
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-5 (2022)
CAR T cell therapy is an effective cancer treatment, but biological and manufacturing hurdles hamper its broad breakthrough. Although the first step towards automated manufacture of CAR cells has been taken, new technologies are needed to enable the
Externí odkaz:
https://doaj.org/article/2972014f65864c6caffed95aff62b0a0
Autor:
Thomas Walter Georgi, Carmen Fernandez-Perez, Sandra Hoffmann, Andreas Boldt, Lars Kurch, Enrica Bach, Janine Kirchberg, Klaus Metzeler, Carmen Herling, Madlen Jentzsch, Sebastian Schwind, Simon M. Krauß, Naima Petermann, Georg-Nikolaus Franke, Paul Franz, Marco Herling, Stephan Fricke, Regine Kluge, Timm Denecke, Osama Sabri, Ulrich Sack, Ulrike Koehl, Uwe Platzbecker, Ronald Weiss, Vladan Vucinic
Publikováno v:
HemaSphere, Vol 7, p e26116cf (2023)
Externí odkaz:
https://doaj.org/article/e5b84ab9bdf944a082bbb9c3bac14b85
Autor:
Johannes R. Schmidt, Janine Haupt, Sina Riemschneider, Christoph Kämpf, Dennis Löffler, Conny Blumert, Kristin Reiche, Ulrike Koehl, Stefan Kalkhof, Jörg Lehmann
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates a broad range of target genes involved in the xenobiotic response, cell cycle control and circadian rhythm. AhR is constitutively expressed in m
Externí odkaz:
https://doaj.org/article/50c2080dfa3c40d1835ec887c54f41ce