Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ulrike Hübenthal"'
Autor:
Laura Nimtz, Julia Hartmann, Julia Tigges, Stefan Masjosthusmann, Martin Schmuck, Eike Keßel, Stephan Theiss, Karl Köhrer, Patrick Petzsch, James Adjaye, Claudia Wigmann, Dagmar Wieczorek, Barbara Hildebrandt, Farina Bendt, Ulrike Hübenthal, Gabriele Brockerhoff, Ellen Fritsche
Publikováno v:
Stem Cell Research, Vol 45, Iss , Pp - (2020)
Neurotoxicity is mediated by a variety of modes-of-actions leading to disturbance of neuronal function. In order to screen larger numbers of compounds for their neurotoxic potential, in vitro functional neuronal networks (NN) might be helpful tools.
Externí odkaz:
https://doaj.org/article/6ce21a344da041f7ac23989029624edd
Autor:
Jördis Klose, Lu Li, Melanie Pahl, Farina Bendt, Ulrike Hübenthal, Christian Jüngst, Patrick Petzsch, Astrid Schauss, Karl Köhrer, Ping Chung Leung, Chi Chiu Wang, Katharina Koch, Julia Tigges, Xiaohui Fan, Ellen Fritsche
Publikováno v:
Cell Biology and Toxicology. 39:319-343
Adverse outcome pathways (AOPs) are organized sequences of key events (KEs) that are triggered by a xenobiotic-induced molecular initiating event (MIE) and summit in an adverse outcome (AO) relevant to human or ecological health. The AOP framework ca
Autor:
Jonathan Blum, Stefan Masjosthusmann, Kristina Bartmann, Farina Bendt, Xenia Dolde, Arif Dönmez, Nils Förster, Anna-Katharina Holzer, Ulrike Hübenthal, Hagen Eike Keßel, Sadiye Kilic, Jördis Klose, Melanie Pahl, Lynn-Christin Stürzl, Iris Mangas, Andrea Terron, Kevin M. Crofton, Martin Scholze, Axel Mosig, Marcel Leist, Ellen Fritsche
Developmental neurotoxicity (DNT) is a major safety concern for all chemicals of the human exposome. However, DNT data from animal studies are available for only a small percentage of manufactured compounds. Test methods with a higher throughput than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04065f0054d0235280408ccf7d7668ba
https://zenodo.org/record/7752644
https://zenodo.org/record/7752644
Autor:
Adrian Covaci, Julia Tigges, Mamta Behl, Marcel Leist, Stefan Masjosthusmann, Hagen Eike Keßel, Lynn-Christin Stürzl, Ulrike Hübenthal, Andrea Rossi, Melanie Pahl, Jördis Klose, Nils Förster, Jonathan Blum, Katharina Koch, Sabine Schneider, Xenia Dolde, Ellen Fritsche, Farina Bendt, Anna-Katharina Holzer, Kristina Bartmann, Selina Woeste
Publikováno v:
Cell biology and toxicology
Due to their neurodevelopmental toxicity, flame retardants (FRs) like polybrominated diphenyl ethers are banned from the market and replaced by alternative FRs, like organophosphorus FRs, that have mostly unknown toxicological profiles. To study thei
Autor:
Stefan Masjosthusmann, Ellen Fritsche, Farina Bendt, Jenny Baumann, Clara Siebert, Ulrike Hübenthal
Publikováno v:
Chemosphere. 235:447-456
Arsenic exposure disturbs brain development in humans. Although developmental neurotoxicity (DNT) of arsenic has been studied in vivo and in vitro, its mode-of-action (MoA) is not completely understood. Here, we characterize the adverse neurodevelopm
Autor:
Constanze Uhlmann, Ann‐Christin Nickel, Daniel Picard, Andrea Rossi, Guanzhang Li, Barbara Hildebrandt, Gabriele Brockerhoff, Farina Bendt, Ulrike Hübenthal, Michael Hewera, Hans‐Jakob Steiger, Dagmar Wieczorek, Aristoteles Perrakis, Wei Zhang, Marc Remke, Katharina Koch, Julia Tigges, Roland S. Croner, Ellen Fritsche, Ulf D. Kahlert
Publikováno v:
Biotechnology Journal. 17:2100693
Limitations in genetic stability and recapitulating accurate physiological disease properties challenge the utility of patient-derived (PD) cancer models for reproducible and translational research. A portfolio of isogenic human induced pluripotent s
TBBPA targets converging key events of human oligodendrocyte development resulting in two novel AOPs
Autor:
Ellen Fritsche, Ulrike Hübenthal, Karl Köhrer, Patrick Petzsch, Farina Bendt, Katharina Schmuck, Katharina Koch, Stefan Masjosthusmann, Jördis Klose, Julia Tigges
Publikováno v:
ALTEX
Myelinating oligodendrocytes (OLs) establish saltatory nerve conduction during white matter development. Thus, interference with oligodendrogenesis leads to an adverse outcome on brain performance in the child due to aberrant myelination. An intertwi
Autor:
Xenia Dolde, Nils Förster, Ulrike Hübenthal, Kristina Bartmann, Lynn-Christin Stürzl, Marcel Leist, Ellen Fritsche, Anna-Katharina Holzer, Arif Dönmez, Jördis Klose, Jaffar Kisitu, Stefan Masjosthusmann, Melanie Pahl, Farina Bendt, Jonathan Blum, Axel Mosig, Ilinca Suciu, Tanja Waldmann, Eike Hagen Keßel
Publikováno v:
EFSA Supporting Publications. 17
Autor:
Ulrike Hübenthal, Dagmar Wieczorek, Ellen Fritsche, Farina Bendt, James Adjaye, Stefan Masjosthusmann, Julia Hartmann, Stephan Theiss, Gabriele Brockerhoff, Julia Tigges, Barbara Hildebrandt, Karl Köhrer, Martin Schmuck, Laura Nimtz, Eike Keßel, Claudia Wigmann, Patrick Petzsch
Publikováno v:
Stem Cell Research, Vol 45, Iss, Pp-(2020)
Neurotoxicity is mediated by a variety of modes-of-actions leading to disturbance of neuronal function. In order to screen larger numbers of compounds for their neurotoxic potential, in vitro functional neuronal networks (NN) might be helpful tools.
Autor:
Ellen Fritsche, Jördis Klose, Ulrike Hübenthal, Jenny Baumann, René Deenen, Clara Siebert, Stefan Masjosthusmann, Daniel Becker, Katharina Dach, Karl Köhrer, Barbara Petzuch, Julia Tigges, Marta Barenys
Publikováno v:
Toxicology and applied pharmacology. 354
It is widely accepted that human brain development has unique features that cannot be represented by rodents. Obvious reasons are the evolutionary distance and divergent physiology. This might lead to false predictions when rodents are used for safet