Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ulrike Gradhand"'
Autor:
Alice Habermeier, Peter Nürnberg, Thomas Lang, Ellen I. Closs, Christine Fischer, Mohammad R. Toliat, Sherif Mehralivand, Martin F. Fromm, Ulrich M. Zanger, Daniel Janke, Ulrike Gradhand, Peter Fritz, Leszek Wojnowski, Ute Gödtel-Armbrust, Dennis Strand, Matthias Schwab
Publikováno v:
Human Mutation. 29:659-669
Multiple drug resistance protein 4 (MRP4, ABCC4) belongs to the C subfamily of the ATP-binding cassette (ABC) transporter superfamily and participates in the transport of diverse antiviral and chemotherapeutic agents such as 6-mercaptopurine (6-MP) a
Autor:
Matthias Schwab, Heyo K. Kroemer, Ulrich M. Zanger, B Anwald, Thomas Lang, Michel Eichelbaum, Elke Schaeffeler, Peter Fritz, Iouri Bachmakov, Gabriele Jedlitschky, Hartmut Glaeser, Martin F. Fromm, H Tegude, Kathrin Klein, Ulrike Gradhand, Reinhold Kerb
Publikováno v:
The Pharmacogenomics Journal. 8:42-52
The multidrug resistance protein 4 (MRP4) is an efflux transporter involved in the transport of endogenous substrates and xenobiotics. We measured MRP4 mRNA and protein expression in human livers and found a 38- and 45-fold variability, respectively.
Publikováno v:
Life Sciences. 80:1490-1494
The multidrug resistance protein 3 (MRP3/gene symbol: ABCC3) is an ATP-dependent efflux pump mediating the transport of endogenous glucuronides and conjugated drug metabolites across cell membranes. In humans the hepatic expression of ABCC3 mRNA seem
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 372:432-443
Organic anion transporting polypeptides (OATPs) mediate the uptake of a broad range of compounds into cells. Substrates for members of the OATP family include bile salts, hormones, and steroid conjugates as well as drugs like the HMG-CoA-reductase in
Autor:
Gary K. O’Donovan, Steven R. Skinner, Barry A. Morgan, Bruce Belanger, Matthew T. Labenski, Kerry White, Dennis Benjamin, Paolo A. Centrella, Elisabeth Doyle, Heather S. Blanchette, Ulrike Gradhand, Nazbeh Taghizadeh, Sarah T Griffin, Teresa M Caiazzo, Kavirayani R. Prasad, James Wakefield, William F. Westlin, Jennifer L. DeLorey, Susan E. Hill, Charles D. Thompson, Christopher C. Arico-Muendel
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 41(4)
The natural product fumagillin exhibits potent antiproliferative and antiangiogenic properties. The semisynthetic analog PPI-2458, [(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] N-[(2R)-1-am
Autor:
Ulrike Gradhand, Richard B. Kim
Publikováno v:
Drug metabolism reviews. 40(2)
Elucidation of the key mechanisms that confer interindividual differences in drug response remains an important focus of drug disposition and clinical pharmacology research. We now know both environmental and host genetic factors contribute to the ap
Autor:
Gradhand, Ulrike1 (AUTHOR), Kim, Richard B.1 (AUTHOR) Richard.Kim@Lhsc.on.ca
Publikováno v:
Drug Metabolism Reviews. May2008, Vol. 40 Issue 2, p317-354. 38p. 5 Diagrams, 5 Charts.
Publikováno v:
Journal of Clinical Pharmacology; Nov2012, Vol. 52 Issue 11, p1689-1697, 9p
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology; Mar2006, Vol. 372 Issue 6, p432-443, 12p, 1 Diagram, 2 Charts, 1 Graph
Publikováno v:
Pharmazie in userer Zeit; Sep2006, Vol. 35 Issue 5, p455-457, 3p