Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Ulrike Dijkman"'
Autor:
Ulrike Dijkman, Joost H.A. Folgering, Gunnar Flik, Ben H.C. Westerink, Kenneth W. Perry, Kjell A. Svensson, Matthew J. Fell, Bryan J. Johnson
Publikováno v:
Neuropharmacology. 99:1-8
The interactions between the glutamatergic and the histaminergic systems in the brain are not fully understood. Here we studied histamine release in the medial prefrontal cortex and the posterior hypothalamus-tuberomamillary nucleus (PH-TMN) using in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d7ab7db66affa816a3019d3f0aa2dc
https://doi.org/10.1016/j.neuropharm.2015.05.034
https://doi.org/10.1016/j.neuropharm.2015.05.034
Autor:
Amyaouch Bradaia, Heike Deisemann, Larry Park, Simon Gelman, Esther Steidl, Melanie Gleyzes, Ulrike Dijkman, Celia Dominguez, Leticia Toledo-Sherman, Vinod Khetarpal, Outi Kontkanen, Dirk Winkler, Ioana Neagoe, Robert Freije, Mariette Heins, Taneli Heikkinen, Jukka Puoliväli, Robyn M. Javier, Ladislav Mrzljak, Vahri Beaumont, Geoffrey Tombaugh, Kimmo Lehtimäki, Arash Rassoulpour, Ignacio Munoz-Sanjuan, Andreas Ebneth
Publikováno v:
Experimental neurology. 282
Dysregulation of the kynurenine (Kyn) pathway has been associated with the progression of Huntington's disease (HD). In particular, elevated levels of the kynurenine metabolites 3-hydroxy kynurenine (3-OH-Kyn) and quinolinic acid (Quin), have been re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d57b9e5523dde3c9240d7287e850c32
https://pubmed.ncbi.nlm.nih.gov/27163548
https://pubmed.ncbi.nlm.nih.gov/27163548
Autor:
Leticia Toledo-Sherman, Catherine M. O'Connell, Christopher John Yarnold, Michael Prime, Suganathan Selvaratnam, Ignacio Munoz-Sanjuan, Ladislav Mrzljak, Arash Rassoulpour, Kimberly L Matthews, Patricia Wheelan, Laura Reed, Wolfgang Reindl, Alan Beresford, Estelle Hamelin-Flegg, Derek Alexander Weddell, William L. Mitchell, Dawn Yates, Maria Beconi, Weslyn Ward Friley, Christopher John Brown, Christin Winkler, Stephen Martin Courtney, Valerie Kempf, John Wityak, Naomi Went, Celia Dominguez, Isabell Cardaun, Kendall D. Powell, Ulrike Dijkman, Peter Johnson, Frederick Arthur Brookfield, Dirk Winkler, De Aguiar Pena Paula C, Kathy Lyons
Publikováno v:
Journal of medicinal chemistry. 58(3)
We report on the development of a series of pyrimidine carboxylic acids that are potent and selective inhibitors of kynurenine monooxygenase and competitive for kynurenine. We describe the SAR for this novel series and report on their inhibition of K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699f24106f0a18d2d3d4ac5e1d3ff8ca
https://pubmed.ncbi.nlm.nih.gov/25590515
https://pubmed.ncbi.nlm.nih.gov/25590515