Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ulrike Bruning"'
Autor:
Anna Kuchnio, Stijn Moens, Ulrike Bruning, Karol Kuchnio, Bert Cruys, Bernard Thienpont, Michaël Broux, Andreea Alexandra Ungureanu, Rodrigo Leite de Oliveira, Françoise Bruyère, Henar Cuervo, Ann Manderveld, An Carton, Juan Ramon Hernandez-Fernaud, Sara Zanivan, Carmen Bartic, Jean-Michel Foidart, Agnes Noel, Stefan Vinckier, Diether Lambrechts, Mieke Dewerchin, Massimiliano Mazzone, Peter Carmeliet
Publikováno v:
Cell Reports, Vol 12, Iss 6, Pp 992-1005 (2015)
Several questions about the role of the oxygen sensor prolyl-hydroxylase 2 (PHD2) in cancer have not been addressed. First, the role of PHD2 in metastasis has not been studied in a spontaneous tumor model. Here, we show that global PHD2 haplodeficien
Externí odkaz:
https://doaj.org/article/84a2f84782c44a938ff33527b7a39ea2
Autor:
Morgan Essex, Belén Millet Pascual-Leone, Ulrike Löber, Mathias Kuhring, Bowen Zhang, Ulrike Brüning, Raphaela Fritsche-Guenther, Marta Krzanowski, Facundo Fiocca Vernengo, Sophia Brumhard, Ivo Röwekamp, Agata Anna Bielecka, Till Robin Lesker, Emanuel Wyler, Markus Landthaler, Andrej Mantei, Christian Meisel, Sandra Caesar, Charlotte Thibeault, Victor M. Corman, Lajos Marko, Norbert Suttorp, Till Strowig, Florian Kurth, Leif E. Sander, Yang Li, Jennifer A. Kirwan, Sofia K. Forslund, Bastian Opitz
Publikováno v:
npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract The clinical course of COVID-19 is variable and often unpredictable. To test the hypothesis that disease progression and inflammatory responses associate with alterations in the microbiome and metabolome, we analyzed metagenome, metabolome,
Externí odkaz:
https://doaj.org/article/3800ac4d0de04e14b83d18bba159a41d
Autor:
Patrick J. Dörner, Harithaa Anandakumar, Ivo Röwekamp, Facundo Fiocca Vernengo, Belén Millet Pascual-Leone, Marta Krzanowski, Josua Sellmaier, Ulrike Brüning, Raphaela Fritsche-Guenther, Lennart Pfannkuch, Florian Kurth, Miha Milek, Vanessa Igbokwe, Ulrike Löber, Birgitt Gutbier, Markus Holstein, Gitta Anne Heinz, Mir-Farzin Mashreghi, Leon N. Schulte, Ann-Brit Klatt, Sandra Caesar, Sandra-Maria Wienhold, Stefan Offermanns, Matthias Mack, Martin Witzenrath, Stefan Jordan, Dieter Beule, Jennifer A. Kirwan, Sofia K. Forslund, Nicola Wilck, Hendrik Bartolomaeus, Markus M. Heimesaat, Bastian Opitz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Hospital-acquired pneumonia (HAP) is associated with high mortality and costs, and frequently caused by multidrug-resistant (MDR) bacteria. Although prior antimicrobial therapy is a major risk factor for HAP, the underlying mechanism remains
Externí odkaz:
https://doaj.org/article/41a8a643c26b41c0b66352c312b98b9b
Autor:
Peter Carmeliet, Aleksandra Brajic, Anna Rita Cantelmo, Joanna Kalucka, Bart Ghesquière, Ann Bouché, Ulrike Bruning, Mieke Dewerchin, Laure-Anne Teuwen, Andreas Pircher, Lena-Christin Conradi, Stefan Vinckier
Publikováno v:
Angiogenesis. 20:599-613
Blockade of the glycolytic activator PFKFB3 in cancer cells (using a maximum tolerable dose of 70 mg/kg of the PFKFB3 blocker 3PO) inhibits tumor growth in preclinical models and is currently being tested as a novel anticancer treatment in phase I cl
Autor:
Agnès Noël, René Hägerling, Peter Carmeliet, Silvia Blacher, Veronica Moral-Darde, Brian W. Wong, Hui Zhao, Cathrin Dierkes, Aernout Luttun, Martin Lippens, Bart Ghesquière, Mieke Dewerchin, Bernard Thienpont, Sarah-Maria Fendt, Xingwu Wang, Joanna Kalucka, Lieve Moons, Annalisa Zecchin, Luc Schoonjans, Ulrike Bruning, Marlen Knobloch, Rindert Missiaen, Stefan Vinckier, Sabine Wyns, Hongling Huang, Diether Lambrechts, Guy Eelen, Ivo Cornelissen, Sebastian Jessberger, Friedemann Kiefer, Jermaine Goveia, Chenyan Shi, Melissa García-Caballero
Publikováno v:
Nature. 542:49-54
Lymphatic vessels are lined by lymphatic endothelial cells (LECs), and are critical for health. However, the role of metabolism in lymphatic development has not yet been elucidated. Here we report that in transgenic mouse models, LEC-specific loss of
Autor:
Rongyuan Chen, Katrien De Bock, Federico Taverna, Elizabeth A. V. Jones, Massimiliano Mazzone, Lena-Christin Conradi, Jermaine Goveia, Rindert Missiaen, Bart Ghesquière, Peter Carmeliet, Anna Rita Cantelmo, Bernard Gallez, Bert Cruys, Mieke Dewerchin, Bernard Thienpont, Richard M Cubbon, Francisco Morales-Rodriguez, Sarah-Maria Fendt, Sandra Schoors, Ulrike Bruning, Annalisa Zecchin, Diether Lambrechts, Xavier Sagaert, Sebastian Jessberger, Xuri Li, Joanna Kalucka, Ulrike Harjes, Guy Eelen, Ilaria Elia, Kim Vriens, Gregor-Alexander Pilz, Nadine V. Conchinha, Aleksandra Brajic, Charlotte Dubois, Pauline de Zeeuw, Brian W. Wong, Samantha Scheinok, Laura Bierhansl, Lucas Treps
Publikováno v:
Cell metabolism, Vol. 28, no. 6, p. 881-894.e13 (2018)
Cell Metabolism
Cell Metabolism, 28(6), 881-894.e13. Cell Press
Cell Metabolism
Cell Metabolism, 28(6), 881-894.e13. Cell Press
Little is known about the metabolism of quiescent endothelial cells (QECs). Nonetheless, when dysfunctional, QECs contribute to multiple diseases. Previously, we demonstrated that proliferating endothelial cells (PECs) use fatty acid β-oxidation (FA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d56f53f8e852ef8e7f9fbf714d7b9a3
https://eprints.whiterose.ac.uk/135199/1/CELL-METABOLISM-FAO_quiescence_accepted.pdf
https://eprints.whiterose.ac.uk/135199/1/CELL-METABOLISM-FAO_quiescence_accepted.pdf
Autor:
Christian Lange, Johan Hofkens, Sandra Liekens, Hongling Huang, Xu Wu, Joris Souffreau, Giorgio Saladino, Guy Eelen, Jaap D. van Buul, Saar Vandekeere, Wouter H. Lamers, Xuri Li, Gopala K. Jarugumilli, Federico Comitani, Annalisa Zecchin, Jermaine Goveia, Bert Cruys, Katleen Brepoels, Joanna Kalucka, Bart Ghesquière, Leanne M. Ramer, Ulrike Bruning, Michael DeRan, Charlotte Dubois, Francesco Luigi Gervasio, Jos van Rijssel, Stefan Vinckier, Sabine Wyns, Yi I. Wu, Mieke Dewerchin, Francisco Morales-Rodriguez, Susana Rocha, Rongyuan Chen, Richard M Cubbon, Luc Schoonjans, Lucas Treps, Peter Carmeliet, Anna Rita Cantelmo, Jurgen Haustraete
Publikováno v:
Nature, 561(7721), 63-69. Nature Publishing Group
Nature
Nature
Glutamine synthetase, encoded by the gene GLUL, is an enzyme that converts glutamate and ammonia to glutamine. It is expressed by endothelial cells, but surprisingly shows negligible glutamine-synthesizing activity in these cells at physiological glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d200895d1b6e0032d3de22a7951093
Autor:
Katrien De Bock, Ward Heggermont, Rindert Missiaen, Stefan Vinckier, Stefan Christen, Holger Gerhardt, Jermaine Goveia, Gitte Borgers, Sarah-Maria Fendt, Karla C. S. Queiroz, Mieke Dewerchin, Annalisa Zecchin, Lucica Godde, Ulrike Bruning, Myriam Baes, Luc Schoonjans, Paul P. Van Veldhoven, Ilaria Elia, Sandra Schoors, Peter Carmeliet, Anna Rita Cantelmo, Bart Ghesquière, Guy Eelen, Sophia Y. Lunt
Publikováno v:
Nature
The metabolism of endothelial cells during vessel sprouting remains poorly studied. Here we report that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO), causes vascular sprouting defects due to impaired proliferation,
Autor:
Ulrike Bruning, Asjad Visnagri, Katleen Brepoels, Saar Vandekeere, Hongling Huang, Laura Bierhansl, Stephen Rayport, Nadira Yuldasheva, Stefan Vinckier, Luc Schoonjans, Sabine Wyns, Bert Cruys, Jermaine Goveia, Bart Ghesquière, Joanna Kalucka, Peter Carmeliet, Guy Eelen, Mieke Dewerchin, Annalisa Zecchin, Richard M Cubbon
Endothelial cell (EC) metabolism is emerging as a regulator of angiogenesis, but the precise role of glutamine metabolism in ECs is unknown. Here, we show that depriving ECs of glutamine or inhibiting glutaminase 1 (GLS1) caused vessel sprouting defe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44fa18da3e38360a36ebabdb44cb2ccd
https://eprints.whiterose.ac.uk/118500/1/GLS_EMBO_(28.5.17_2a)_GE3.docx
https://eprints.whiterose.ac.uk/118500/1/GLS_EMBO_(28.5.17_2a)_GE3.docx
Autor:
Susan F. Fitzpatrick, Mario C. Manresa, Zsolt Fábián, Alex von Kriegsheim, Cormac T. Taylor, Peter Carmeliet, Yvonne M. O'Meara, Glen Doherty, Zongwei Li, Peter Fraisl, Eoin P. Cummins, Bettina Schaible, Murtaza M. Tambuwala, Myriam Baes, Craig Slattery, Ulrike Bruning, Javier Rodriguez, Xingnan Zheng, Colin R. Lenihan, Desmond G. Higgins, Thomas Schwarzl
Publikováno v:
Fitzpatrick, S F, Fábián, Z, Schaible, B, Lenihan, C R, Schwarzl, T, Rodriguez, J, Zheng, X, Li, Z, Tambuwala, M M, Higgins, D G, O'Meara, Y, Slattery, C, Manresa, M C, Fraisl, P, Bruning, U, Baes, M, Carmeliet, P, Doherty, G, von Kriegsheim, A, Cummins, E P & Taylor, C T 2016, ' Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner ', Biochemical and Biophysical Research Communications, vol. 474, no. 3, pp. 579-86 . https://doi.org/10.1016/j.bbrc.2016.04.085
Hepatocyte death is an important contributing factor in a number of diseases of the liver. PHD1 confers hypoxic sensitivity upon transcription factors including the hypoxia inducible factor (HIF) and nuclear factor-kappaB (NF-κB). Reduced PHD1 activ