Výsledky vyhledávání - "Ulrike, Liewer"

Targeting positive regulatory domain I-binding factor 1 and X box-binding protein 1 transcription factors by multiple myeloma-reactive CTL

Autor: Edite Antunes Ferreira, Nicole Oehlrich, Sandra Schneider, Carina Lotz, Marion Moos, Ulrike Liewer, Matthias Theobald, Hartmut Goldschmidt, Michael Hundemer, Susanne Strand, Sarah Abdel Mutallib, Christoph Huber

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 175(2)

Growing evidence indicates that multiple myeloma (MM) and other malignancies are susceptible to CTL-based immune interventions. We studied whether transcription factors inherently involved in the terminal differentiation of mature B lymphocytes into

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53eff318a3577eea2f01ba61d2d83c0
https://pubmed.ncbi.nlm.nih.gov/16002735

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The effect of the interferon-gamma-inducible processing machinery on the generation of a naturally tumor-associated human cytotoxic T lymphocyte epitope within a wild-type and mutant p53 sequence context

Autor: Ulrike, Kuckelkorn, Edite Antunes, Ferreira, Ilse, Drung, Ulrike, Liewer, Peter-Michael, Kloetzel, Matthias, Theobald

Publikováno v: European journal of immunology. 32(5)

The human wild-type (wt) p53.264-272 peptide is a universal tumor antigen and recognized by HLA-A*0201 (A2.1)-restricted CTL. Generation of this epitope by constitutive 20S proteasomes is prevented by a p53 R to H hotspot mutation at the C-terminal f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c744c0643af97c61a70828df9a656131
https://pubmed.ncbi.nlm.nih.gov/11981824

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The sequence alteration associated with a mutational hotspot in p53 protects cells from lysis by cytotoxic T lymphocytes specific for a flanking peptide epitope

Autor: Christoph Huber, Ulrike Liewer, Arnold J. Levine, Javier Hernandez, Thomas Ruppert, Peter-M. Kloetzel, Judith A. Biggs, Linda A. Sherman, Edite Antunes Ferreira, Annett Häussler, Matthias Theobald, Ulrich H. Koszinowski, Ulrike Kuckelkorn

Publikováno v: The Journal of Experimental Medicine

A high proportion of tumors arise due to mutation of the p53 tumor suppressor protein. A p53 hotspot mutation at amino acid position 273 from R to H, flanking a peptide epitope that spans residues 264–272, renders cells resistant to killing by huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc32671c4b492007c50c2927a2e423ff
https://pubmed.ncbi.nlm.nih.gov/9743520

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The effect of the interferon-γ-inducible processing machinery on the generation of a naturally tumor-associated human cytotoxic T lymphocyte epitope within a wild-type and mutant p53 sequence context

Autor: Edite Antunes Ferreira, Ulrike Liewer, Matthias Theobald, Peter-Michael Kloetzel, Ulrike Kuckelkorn, Ilse Drung

Publikováno v: European Journal of Immunology. 32:1368

The human wild-type (wt) p53.264–272 peptide is a universal tumor antigen and recognized by HLA-A*0201 (A2.1)-restricted CTL. Generation of this epitope by constitutive 20S proteasomes is prevented by a p53 R to H hotspot mutation at the C-terminal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cb7967908f1ca0bd7ca60eeb67c2e1f
https://doi.org/10.1002/1521-4141(200205)32:5<1368::aid-immu1368>3.0.co

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