Stereocontrolled [11 C]Alkylation of N-Terminal Glycine Schiff Bases To Obtain Dipeptides

Autor: Alex J. Poot, Ulrike Filp, Albert D. Windhorst, Aleksandra Pekošak

Publikováno v: European Journal of Organic Chemistry. 2017:5592-5596

The use of various quaternary ammonium salts as chiral phase-transfer catalysts allowed effective and stereoselective radiochemical [11C]alkylation to obtain functionalized dipeptides. We herein report a broadly applicable procedure for the asymmetri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f989501b6c31026f4635a9edb0345b29
https://doi.org/10.1002/ejoc.201701129

From Carbon-11-Labeled Amino Acids to Peptides in Positron Emission Tomography: the Synthesis and Clinical Application

Autor: Ulrike Filp, Alex J. Poot, Albert D. Windhorst, Aleksandra Pekošak

Publikováno v: Pekošak, A, Filp, U, Poot, A J & Windhorst, A D 2018, ' From Carbon-11-Labeled Amino Acids to Peptides in Positron Emission Tomography : the Synthesis and Clinical Application ', Molecular Imaging and Biology, vol. 20, no. 4, pp. 510-532 . https://doi.org/10.1007/s11307-018-1163-5

Radiolabeled amino acids, their derivatives and peptides have a broad scope of application and can be used as receptor ligands, as well as enzyme substrates for many different diseases as radiopharmaceutical tracers. Over the past few decades, the ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723f00f7183191b79ac065db5b83a29b
https://pubmed.ncbi.nlm.nih.gov/29411226

Radiosynthesis of 1-iodo-2-[11C]methylpropane and 2-methyl-1-[11C]propanol and its application for alkylation reactions and C―C bond formation

Autor: Albert D. Windhorst, Uta Funke, Alex J. Poot, Aleksandra Pekošak, Ulrike Filp, Lonneke Rotteveel, Adriaan A. Lammertsma

Publikováno v: Rotteveel, L, Poot, A J, Funke, U, Pekošak, A, Filp, U, Lammertsma, A A & Windhorst, A D 2017, ' Radiosynthesis of 1-iodo-2-[ 11 C]methylpropane and 2-methyl-1-[ 11 C]propanol and its application for alkylation reactions and C―C bond formation ', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 60, no. 12, pp. 566-576 . https://doi.org/10.1002/jlcr.3536
Journal of Labelled Compounds and Radiopharmaceuticals, 60(12), 566-576. John Wiley and Sons Ltd

The multitude of biologically active compounds requires the availability of a broad spectrum of radiolabeled synthons for the development of positron emission tomography (PET) tracers. The aim of this study was to synthesize 1-iodo-2-[11C]methylpropa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f54f37610dc09cbaedb9506ce32f93d
https://research.vumc.nl/en/publications/93800d09-bc91-46c9-9a09-e1978be8e18e

A rapid and highly enantioselective C-11C bond formation of l-[11C]phenylalanine via chiral phase-transfer catalysis

Autor: Ulrike Filp, Alex J. Poot, Albert D. Windhorst, Janja Skrinjar, Aleksandra Pekošak

Publikováno v: Organic and Biomolecular Chemistry, 15(3), 570-575. Royal Society of Chemistry
Pekošak, A, Filp, U, Škrinjar, J, Poot, A J & Windhorst, A D 2017, ' A rapid and highly enantioselective C-11 C bond formation of l-[ 11 C]phenylalanine via chiral phase-transfer catalysis ', Organic and Biomolecular Chemistry, vol. 15, no. 3, pp. 570-575 . https://doi.org/10.1039/c6ob02633h

A rapid method for the synthesis of carbon-11 radiolabeled phenylalanine was developed using a chiral phase-transfer catalyst and a sub-nanomolar quantity of [11C]benzyl iodide as a radio-precursor. Based on a reported synthesis of [11C]benzyl iodide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663a15621a39c5d124fee8e37f4cd78a
https://research.vumc.nl/en/publications/4e24e542-26f3-434b-80d9-ade94904bce6

Improved synthesis and application of [(11) C]benzyl iodide in positron emission tomography radiotracer production

Autor: Aleksandra, Pekošak, Ulrike, Filp, Lonneke, Rotteveel, Alex J, Poot, Albert D, Windhorst

Publikováno v: Journal of labelled compoundsradiopharmaceuticals. 58(8)

Positron emission tomography has increased the demand for new carbon-11 radiolabeled tracers and building blocks. A promising radiolabeling synthon is [(11) C]benzyl iodide ([(11) C]BnI), because the benzyl group is a widely present functionality in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eec5d83c7f7a6f25e530c9e9a5cee934
https://pubmed.ncbi.nlm.nih.gov/26031614