Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ulrike, Bischoff"'
Autor:
Morten B. Thomsen, Roel L.H.M.G. Spätjens, Marc A. Vos, Jørgen Matz, Morten A Kall, Kristen Frederiksen, Paul G.A. Volders, Ulrike Bischoff, Jet D.M. Beekman, Milan Stengl
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics, 307(2), 776-784. American Society for Pharmacology and Experimental Therapeutics
Inhibition of the potassium current I-Kr and QT prolongation are associated with drug-induced torsades de pointes arrhythmias (TdP) and sudden cardiac death. We investigated the cardiac electrophysiological effects of sertindole, an antipsychotic dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872264997c6ffa8fa81fe3638cfa0b8a
https://doi.org/10.1124/jpet.103.052753
https://doi.org/10.1124/jpet.103.052753
Publikováno v:
British Journal of Pharmacology. 139:1273-1280
(1) Hyperpolarizing voltage steps evoke slowly activating inward currents in a variety of neurones and in cardiac cells. This hyperpolarization-activated inward current (I(h)) is thought to play a significant role in cell excitability, firing frequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee2aa19a3493cd884ed6a558d7013592
https://doi.org/10.1038/sj.bjp.0705363
https://doi.org/10.1038/sj.bjp.0705363
Publikováno v:
Drug Discovery Today. 6:78-84
The late detection of cardiotoxic side effects, such as QT prolongation, induced by compounds of pharmacological interest can dramatically impede drug discovery and development projects, and consequently increase their cost. The launch of new drugs w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3615d330f072c9d086852b83b7c9c43
https://doi.org/10.1016/s1359-6446(00)01602-0
https://doi.org/10.1016/s1359-6446(00)01602-0
Publikováno v:
Current opinion in drug discoverydevelopment. 6(4)
Within the past few years, the high-throughput screening (HTS) of compounds targeting cardiac ion channels has been primarily focused on the testing of the HERG channel, which is involved in the termination of cardiac action potential. Interaction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5539836af8ed60719a87f2470120b59f
https://pubmed.ncbi.nlm.nih.gov/12951809
https://pubmed.ncbi.nlm.nih.gov/12951809
Publikováno v:
BMC News and views. 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df1d2bde928d4ff42d83b3379340c0a1
https://doi.org/10.1186/2048-4623-3-s1-op001
https://doi.org/10.1186/2048-4623-3-s1-op001
Publikováno v:
European journal of pharmacology. 406(3)
We have investigated the effects of four fluoroquinolones on the human ether-à-go-go-related gene (HERG) mediated K(+) currents to evaluate their potential to induce QT-prolongation. HERG currents were measured from stably transfected Chinese hamste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9ba411ab45a77e1b3b23f5414f56c8
https://pubmed.ncbi.nlm.nih.gov/11040340
https://pubmed.ncbi.nlm.nih.gov/11040340
Publikováno v:
The Journal of physiology. 510
Whole-cell Na+-activated K+ (KNa) channel currents and single KNa channels were studied with the patch-clamp method in small (20-25 μm) dorsal root ganglion (DRG) neurones in slices of rat dorsal root ganglia. The whole-cell KNa channel current was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa3b7d16920e984416eafea641289e7
https://pubmed.ncbi.nlm.nih.gov/9660890
https://pubmed.ncbi.nlm.nih.gov/9660890
Publikováno v:
CIÊNCIAVITAE
1. Single voltage-activated K+ channels were investigated by means of the patch-clamp technique in small dorsal root ganglion (DRG) neurones in 150 microns thin slices of new-born rat DRG. It was found that K+ conductance in small DRG neurones is for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eef98ac62b668d21a52309e35efbd04
https://europepmc.org/articles/PMC1158925/
https://europepmc.org/articles/PMC1158925/
