Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ulrika S H Svensson"'
Publikováno v:
Biopharmaceutics & Drug Disposition. 24:71-85
Aims: The aims of the study were to characterise the metabolic pattern of artemisinin in human and rat liver microsomes and to assess the magnitude of auto-induction in the rat. Methods: 14C-artemisinin was incubated with human liver microsomes and w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca7bcfcc098ad6b02f889c850d109f5c
https://doi.org/10.1002/bdd.342
https://doi.org/10.1002/bdd.342
Autor:
B Bjorkstrand, Mats O. Karlsson, Mohamed Abdel-Rehim, Per Ljungman, Margareta Bielenstein, M Johansson, Ulrika S H Svensson, Moustapha Hassan, Christina Nilsson, H Olsson
Publikováno v:
British Journal of Clinical Pharmacology. 48:669-677
Aims This study investigated the pharmacokinetics of cyclophosphamide (CP) and its main metabolite 4-hydroxycyclophosphamide (4-OH-CP) in patients with breast cancer undergoing high dose chemothera ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e85de2429aa4e0b9a856832134acc38
https://doi.org/10.1046/j.1365-2125.1999.00090.x
https://doi.org/10.1046/j.1365-2125.1999.00090.x
Autor:
Michael Ashton, Ulrika S H Svensson
Publikováno v:
British Journal of Clinical Pharmacology. 48:528-535
Identification of the human cytochrome P450 enzymes involved in the invitro metabolism of artemisinin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f095cd4a5ad87c6c4b858f8f171dcc0
https://doi.org/10.1046/j.1365-2125.1999.00044.x
https://doi.org/10.1046/j.1365-2125.1999.00044.x
Autor:
Dinh Xuan Huong, Michael Ashton, Ulrika S H Svensson, Nguyen Duy Sy, Nguyen Thi Niêu, Leif Bertilsson, Trinh Ngoc Hai, Jens Lykkesfeldt, Le Dinh Cong, Nguyen Van Huong
Publikováno v:
Clinical Pharmacology & Therapeutics. 64:160-167
Objective This study investigated whether time-dependent artemisinin pharmacokinetics correlated to CYP3A4 or CYP2C19 activity in vivo. Methods Artemisinin (two oral doses per day of 250 mg) was given to nine healthy Vietnamese subjects for 7 days (d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1eb4a0260c0da3bed3daa84a7f9b62
https://doi.org/10.1016/s0009-9236(98)90149-7
https://doi.org/10.1016/s0009-9236(98)90149-7
Publikováno v:
Biopharmaceuticsdrug disposition. 24(2)
The aims of the study were to characterise the metabolic pattern of artemisinin in human and rat liver microsomes and to assess the magnitude of auto-induction in the rat.(14)C-artemisinin was incubated with human liver microsomes and with liver micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b71355942278ff8116883d33f1ba049
https://pubmed.ncbi.nlm.nih.gov/12619052
https://pubmed.ncbi.nlm.nih.gov/12619052
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 26(3)
Artemisinin disappearance rate was more rapid in incubations with liver microsomes from rats pre-treated with oral artemisinin (60 mg/kg/day for 5 days) compared with microsomes from control animals. A single pathway Michaelis-Menten saturable elimin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e03c76b0d8ea25909c64043a3accc2
https://pubmed.ncbi.nlm.nih.gov/11695717
https://pubmed.ncbi.nlm.nih.gov/11695717
Publikováno v:
European journal of clinical pharmacology. 58(5)
Objectives. The aims of this study were to investigate whether artemisinin influences the pharmacokinetics of mefloquine enantiomers or vice versa and to model the antiparasitic effect of these drugs alone and in combination in Plasmodium falciparum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76588e0c54a6638d269a3fdf153a3fb5
https://pubmed.ncbi.nlm.nih.gov/12185558
https://pubmed.ncbi.nlm.nih.gov/12185558
Autor:
Michael Ashton, Ulrika S H Svensson, Leif Bertilsson, Kazuo Mihara, Trinh Ngoc Hai, Gunnel Tybring
Publikováno v:
Fundamentalclinical pharmacology. 13(6)
The purpose of the study was to determine the enantiomer pharmacokinetics of omeprazole and 5-hydroxy-omeprazole before and after administration of the antimalarial artemisinin to confirm artemisinin's ability to induce CYP2C19. Nine healthy male Vie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c80df5d3cf89526b5c83fa8861fd920
https://pubmed.ncbi.nlm.nih.gov/10626755
https://pubmed.ncbi.nlm.nih.gov/10626755
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 29(2)
1. The pharmacokinetics of the antimalarial compound artemisinin were compared in the male and female Sprague-Dawley rat after single dose i.v. (20 mg x kg(-1)) or i.p. (50 mg x kg(-1)) administration of an emulsion formulation. 2. Plasma clearance o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6cd962a77e9bf46b85a0c60e19e7f2a
https://pubmed.ncbi.nlm.nih.gov/10199595
https://pubmed.ncbi.nlm.nih.gov/10199595
Publikováno v:
Clinical Pharmacology & Therapeutics. 73:P87-P87
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb86c5f1a5ffa616ff2f91f3c05232c3
https://doi.org/10.1016/s0009-9236(03)90677-1
https://doi.org/10.1016/s0009-9236(03)90677-1