Azithromycin and high-dose vitamin D for treatment and prevention of asthma-like episodes in hospitalised preschool children: study protocol for a combined double-blind randomised controlled trial

Autor: Klaus Bønnelykke, Hans Bisgaard, Jakob Stokholm, Bo Chawes, Julie Nyholm Kyvsgaard, Ulrik Ralfkiaer, Nilofar Følsgaard, Trine Mølbæk Jensen, Laura Marie Hesselberg, Ann-Marie M Schoos

Publikováno v: BMJ Open, Vol 12, Iss 4 (2022)

Introduction Previous randomised controlled trials (RCTs) suggest antibiotics for treating episodes of asthma-like symptoms in preschool children. Further, high-dose vitamin D supplementation has been shown to reduce the rate of asthma exacerbations

Externí odkaz: https://doaj.org/article/2f50eb49b245467bb730e293f5063ffc

Azithromycin and high-dose vitamin D for treatment and prevention of asthma-like episodes in hospitalised preschool children:Study protocol for a combined double-blind randomised controlled trial

Autor: Julie Nyholm Kyvsgaard, Ulrik Ralfkiaer, Nilofar Følsgaard, Trine Mølbæk Jensen, Laura Marie Hesselberg, Ann-Marie M Schoos, Klaus Bønnelykke, Hans Bisgaard, Jakob Stokholm, Bo Chawes

Publikováno v: Kyvsgaard, J N, Ralfkiaer, U, Følsgaard, N, Jensen, T M, Hesselberg, L M, Schoos, A-M M, Bønnelykke, K, Bisgaard, H, Stokholm, J & Chawes, B 2022, ' Azithromycin and high-dose vitamin D for treatment and prevention of asthma-like episodes in hospitalised preschool children : Study protocol for a combined double-blind randomised controlled trial ', BMJ Open, vol. 12, no. 4, e054762 . https://doi.org/10.1136/bmjopen-2021-054762

IntroductionPrevious randomised controlled trials (RCTs) suggest antibiotics for treating episodes of asthma-like symptoms in preschool children. Further, high-dose vitamin D supplementation has been shown to reduce the rate of asthma exacerbations a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f8236ab30479c426ee915eca50210c
https://curis.ku.dk/ws/files/317096439/e054762.full.pdf

MicroRNA-210, MicroRNA-331, and MicroRNA-7 Are Differentially Regulated in Treated HIV-1–Infected Individuals and Are Associated With Markers of Systemic Inflammation

Autor: Karin K. Pedersen, Kirsten Grønbæk, Susanne Dam Nielsen, Hans O. Madsen, Vibe Ballegaard, Lars P. Ryder, Simon Koplev, Peter Braendstrup, Ulrik Ralfkiaer, Malene Hove, Jan Gerstoft

Publikováno v: JAIDS Journal of Acquired Immune Deficiency Syndromes. 74:e104-e113

OBJECTIVE Inflammation may contribute to an increased risk of cardiovascular disease (CVD) in HIV-1 infection. MicroRNAs (miRNAs) are involved in the regulation of inflammation. In treated HIV-1-infected individuals, we aimed to identify differential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64848b2bf23bd491c704d3a508f5238f
https://doi.org/10.1097/qai.0000000000001191

miR-18b overexpression identifies mantle cell lymphoma patients with poor outcome and improves the MIPI-B prognosticator

Autor: Simon Husby, Mats Ehinger, Christian Garde, Jack B. Cowland, Jan Delabie, Christian H. Geisler, Arne Kolstad, Ulrik Ralfkiaer, Sara Ek, Lone Bredo Pedersen, Riikka Räty, Roza Zandi, Christopher T. Workman, Erik Clasen-Linde, Christer Sundström, Kirsten Grønbæk, Marja-Liisa Karjalainen-Lindsberg, Peter de Nully Brown, Anna Laurell, Mats Jerkeman, Anja Pedersen

Publikováno v: Husby, S, Ralfkiær, U M, Garde, C, Zandi, R, Ek, S, Kolstad, A, Jerkeman, M, Laurell, A, Räty, R, Pedersen, L B, Pedersen, A, Ehinger, M, Sundström, C, Karjalainen-Lindsberg, M-L, Delabie, J, Clasen-Linde, E, Brown, P, Cowland, J B, Workman, C, Geisler, C H & Grønbæk, K 2015, ' miR-18b overexpression identifies mantle cell lymphoma patients with poor outcome and improves the MIPI-B prognosticator ', Blood, vol. 125, no. 17, pp. 2669-2677 . https://doi.org/10.1182/blood-2014-06-584193

Recent studies show that mantle cell lymphoma (MCL) express aberrant microRNA (miRNA) profiles; however, the clinical effect of miRNA expression has not previously been examined and validated in large prospective homogenously treated cohorts. We perf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdf87f4afc55be56643659477341005
https://doi.org/10.1182/blood-2014-06-584193

Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma

Autor: Christoffer Hother, Vasu Punj, Marianne Terndrup Pedersen, Kirsten Grønbæk, Elisabeth Ralfkiaer, Jesper Christensen, Fazila Asmar, Ulrik Ralfkiaer, Anders Busse Nielsen, Anja Pedersen, Peter de Nully Brown, Kristian Helin

Publikováno v: Haematologica. 98:1912-1920

The discovery that the Ten-Eleven Translocation (TET) hydroxylases cause DNA demethylation has fundamentally changed the notion of how DNA methylation is regulated. Clonal analysis of the hematopoetic stem cell compartment suggests that TET2 mutation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3926f076a95eecdf7e26194676342782
https://doi.org/10.3324/haematol.2013.088740