Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ulrik Lytt Rahbek"'
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109939 (2014)
BACKGROUND: Acylation of peptide drugs with fatty acid chains has proven beneficial for prolonging systemic circulation as well as increasing enzymatic stability without disrupting biological potency. Acylation has furthermore been shown to increase
Externí odkaz:
https://doaj.org/article/a915abac3436473e9afd7af20a5a21c4
Autor:
Andreas Vegge, Jacob Wainer, Joy Collins, Ellen Marie Straarup, Ley Mikkel Wennemoes Hvitfeld, Siddartha Tamang, Herskind Peter, Stephen T. Buckley, Rikke Kaae Kirk, Ulrik Lytt Rahbek, Keiko Ishida, Xiaoya Lu, Brian Mouridsen, Jespersen Mikkel Oliver, Mette Poulsen, Stefán B Gunnarsson, Frantisek Hubalek, Johannes Josef Fels, Jorrit Jeroen Water, Alison Hayward, Adam Bohr, Robert Langer, Giovanni Traverso, Abramson Alex G, Morten Revsgaard Frederiksen, Brian Jensen, Jesper Peter Windum, Niclas Roxhed
Publikováno v:
Nat Biotechnol
Oral administration provides a simple and non-invasive approach for drug delivery. However, due to poor absorption and swift enzymatic degradation in the gastrointestinal tract, a wide range of molecules must be parenterally injected to attain requir
Autor:
Joy Collins, Andreas Vegge, Frantisek Hubalek, Shane McDonnell, Tadayuki Yoshitake, Fauziah R. Zakaria, Jacob Wainer, Ryan Yu Tian, Ulrik Lytt Rahbek, Soyoung Kim, Robert Langer, Giovanni Traverso, Alison Hayward, Raissa Yona, Xiaoya Lu, Ester Caffarel-Salvador, Vance Soares, Morten Revsgaard Frederiksen, Daniel Minahan, Keiko Ishida, Jessica Wong, Rebecca McManus, Xiewen Liu, Siddartha Tamang, James G. Fujimoto, Johannes Josef Fels, Sarah R. Stern, Niclas Roxhed
Publikováno v:
Science advances. 7(4)
Alternative means for drug delivery are needed to facilitate drug adherence and administration. Microneedles (MNs) have been previously investigated transdermally for drug delivery. To date, drug loading into MNs has been limited by drug solubility i
Autor:
Ester Caffarel-Salvador, Abramson Alex G, Tomas Landh, Khang Minsoo, Yuan Gao, Robert Langer, Giovanni Traverso, Cody Cleveland, Siddartha Tamang, David Silverstein, Morten Revsgaard Frederiksen, Ulrik Lytt Rahbek, Jorrit Jeroen Water, Johannes Josef Fels, David Dellal, Niclas Roxhed, Joy Collins, Stephen T. Buckley, Anders V. Friderichsen, Rikke Kaae Kirk, Frantisek Hubalek, Andreas Vegge, Alison Hayward
Publikováno v:
PMC
Biomacromolecules have transformed our capacity to effectively treat diseases; however, their rapid degradation and poor absorption in the gastrointestinal (GI) tract generally limit their administration to parenteral routes. An oral biologic deliver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5173590c68b33410f60fe4c51c099c1
https://hdl.handle.net/1721.1/124359
https://hdl.handle.net/1721.1/124359
Autor:
Joy Collins, Ulrik Lytt Rahbek, Tadayuki Yoshitake, Robert Langer, Giovanni Traverso, Alison Hayward, Niclas Roxhed, Yuan Gao, David Dellal, Hsiang-Chieh Lee, Soyoung Kim, Ester Caffarel-Salvador, Johannes Josef Fels, Daniel Minahan, Abramson Alex G, Morten Revsgaard Frederiksen, Jacob Wainer, Siddartha Tamang, James G. Fujimoto, Vance Soares, Xiaoya Lu, Ryan Yu Tian
Publikováno v:
Nat Med
Insulin and other injectable biologic drugs have transformed the treatment of patients suffering from diabetes1,2, yet patients and healthcare providers often prefer to use and prescribe less effective orally dosed medications3-5. Compared with subcu
Autor:
Hsih Yin Tan, Jörg Peter Kutter, Ulrik Lytt Rahbek, Thomas Lars Andresen, Martin Dufva, Sofie Trier
Publikováno v:
PLoS ONE
Tan, H-Y, Trier, S, Rahbek, U L, Dufva, M, Kutter, J P & Andresen, T L 2018, ' A multi-chamber microfluidic intestinal barrier model using Caco-2 cells for drug transport studies ', PLoS ONE, vol. 13, no. 5, e0197101 . https://doi.org/10.1371/journal.pone.0197101
PLoS ONE, Vol 13, Iss 5, p e0197101 (2018)
Tan, H-Y, Trier, S, Rahbek, U L, Dufva, M, Kutter, J P & Andresen, T L 2018, ' A multi-chamber microfluidic intestinal barrier model using Caco-2 cells for drug transport studies ', P L o S One, vol. 13, no. 5, e0197101 . https://doi.org/10.1371/journal.pone.0197101
Tan, H-Y, Trier, S, Rahbek, U L, Dufva, M, Kutter, J P & Andresen, T L 2018, ' A multi-chamber microfluidic intestinal barrier model using Caco-2 cells for drug transport studies ', PLoS ONE, vol. 13, no. 5, e0197101 . https://doi.org/10.1371/journal.pone.0197101
PLoS ONE, Vol 13, Iss 5, p e0197101 (2018)
Tan, H-Y, Trier, S, Rahbek, U L, Dufva, M, Kutter, J P & Andresen, T L 2018, ' A multi-chamber microfluidic intestinal barrier model using Caco-2 cells for drug transport studies ', P L o S One, vol. 13, no. 5, e0197101 . https://doi.org/10.1371/journal.pone.0197101
This paper presents the design and fabrication of a multi-layer and multi-chamber microchip system using thiol-ene ‘click chemistry’ aimed for drug transport studies across tissue barrier models. The fabrication process enables rapid prototyping
Autor:
Mingshi Yang, Shiyan Guo, Ulrik Lytt Rahbek, Chunliu Zhu, Jukka Rantanen, Xiuying Li, Quanlei Zhu, Lars Hovgaard, Yong Gan
Publikováno v:
Biomaterials. 34:9678-9687
Chitosan nanoparticles (NC) have excellent capacity for protein entrapment, favorable epithelial permeability, and are regarded as promising nanocarriers for oral protein delivery. Herein, we designed and evaluated a class of core shell corona nanoli
Publikováno v:
Tissue barriers. 4(2)
Numerous approaches have been explored to date in the pursuit of delivering peptides or proteins via the oral route. One such example is chemical modification, whereby the native structure of a peptide or protein is tailored to provide a more efficie
Autor:
Ulrik Lytt Rahbek, Anne Chauchereau, Flemming Besenbacher, Mingdong Dong, Kenneth A. Howard, Ye-Zi You, David Oupicky, Anne Færch Nielsen, Jørgen Kjems
Publikováno v:
Rahbek, U L, Nielsen, A F, Dong, M, You, Y, Chauchereau, A, Oupicky, D, Besenbacher, F, Kjems, J & Howard, K A 2010, ' Bioresponsive hyperbranched polymers for siRNA and miRNA delivery ', Journal of Drug Targeting, vol. 18, no. 10, pp. 812-20 . https://doi.org/10.3109/1061186X.2010.527982
This work presents the novel use of reducible hyperbranched (rHB) polymers for delivery of RNA interference (RNAi) therapeutics. Cationic poly(amido amine) hyperbranched polymers that contain different contents of reducible disulfide to nonreducible
Autor:
Ebbe Juel Bech Nielsen, Betty Lomstein Pedersen, Mariko Takeda-Morishita, Ulrik Lytt Rahbek, Yukina Aoyama, Takayuki Nakakubo, Noriyasu Kamei
Publikováno v:
Journal of pharmaceutical sciences. 105(2)
Our recent studies show that cell-penetrating peptides (CPPs) have potential to improve the intestinal absorption of peptide and protein drugs safely and effectively when used in the noncovalent drug--CPP approach. To clarify the applicability and li