The invariant chain CD74 protein is a cell surface binding partner of TIMP‐1 in breast cancer cells

Autor: Mikkel Høeberg, Julie Boertmann Noer, Mette Vixø Vistesen, Annette Bartels, Esben Matzen Bech, Sune Boris Nygård, Ulrik Lademann, Jan Stenvang, Siqi Liu, Anja Thoe Fuglsang, Nils Brünner, José Manuel Afonso Moreira

Publikováno v: Molecular Oncology, Vol 17, Iss 8, Pp 1595-1612 (2023)

Tissue inhibitor of metalloproteinases‐1 (TIMP‐1) regulates the proteolytic activity of matrix metalloproteinases (MMPs), playing an important role in the homeostasis of the extracellular matrix. Beyond its well‐known role in tissue maintenance

Externí odkaz: https://doaj.org/article/514da4a7f4ac4728b3148bc37682ce11

Abstract P5-07-08: Identification and characterization of a new TIMP-1 binding protein

Autor: Ulrik Ulrik Lademann, Jan Stenvang, Mikkel Høeberg, Anja T. Fuglsang, Nils Brünner, Mette V Vistesen, Maj Sofie Ørum-Madsen, Sune Boris Nygård, Lena Vinther Jensen, Siqi Liu, José M.A. Moreira, B. Viuff

Publikováno v: Cancer Research. 75:P5-07

Tissue inhibitor of metalloproteinases 1 (Timp-1), is one of the four known endogenous inhibitors of matrix metalloproteinases (MMPs); in recent years, Timp-1 has become increasingly recognized as a multifunctional protein that, independently of its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46362612689ee4db6678dec377e0c53b
https://doi.org/10.1158/1538-7445.sabcs14-p5-07-08

Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization

Autor: Nicole Fehrenbacher, Maria Høyer-Hansen, Mikkel Rohde, Agnieszka Danielewicz, Ulrik Lademann, Marja Jäättelä, Mads Gyrd-Hansen, Jesper Nylandsted, Gabriele Multhoff, Ekkehard Weber

Publikováno v: The Journal of Experimental Medicine

Heat shock protein 70 (Hsp70) is a potent survival protein whose depletion triggers massive caspase-independent tumor cell death. Here, we show that Hsp70 exerts its prosurvival function by inhibiting lysosomal membrane permeabilization. The cell dea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c3e0257a0879ef7716fb68e3c9beaa
https://doi.org/10.1084/jem.20040531

Identifying sources and estimating glandular output of salivary TIMP‐1

Autor: Lars Holten-Andersen, S Beier Jensen, Ulrik Lademann, Birgitte Nauntofte, Peter Højrup, Jakob Harslund, Nils Brünner, Hans Jørgen Nielsen, Morten Thaysen-Andersen, Allan Bardow, P. Autzen Usher, Hanne Offenberg, Jesper Reibel

Publikováno v: Holten-Andersen, L, Beier Jensen, S, Bardow, A, Harslund, J, Thaysen-Andersen, M, Lademann, U, Autzen Usher, P, Offenberg, H, Højrup, P, Reibel, J, Nielsen, H J, Brunner, N & Nauntofte, B 2008, ' Identifying sources and estimating glandular output of salivary TIMP-1 ', Scandinavian Journal of Clinical and Laboratory Investigation. Supplement, vol. 68, no. 7, pp. 548-554 . https://doi.org/10.1080/00365510701883180

Objective. Tissue inhibitor of metalloproteinases 1 (TIMP-1) has been identified as a potential biomarker in diseases such as cancer, cardiovascular diseases and diabetes. Since TIMP-1 resides in most tissues and bodily fluids, we evaluated the poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad24513147c3e403802c3e8f85c0f128
https://doi.org/10.1080/00365510701883180

Measurement of the Uncomplexed Fraction of Tissue Inhibitor of Metalloproteinases-1 in the Prognostic Evaluation of Primary Breast Cancer Patients*

Autor: Vibeke Jensen, Anne Sofie Schrohl, Ib Jarle Christensen, Ulrik Lademann, Sidse Ørnbjerg Würtz, Nils Brünner, Henning T. Mouridsen

Publikováno v: Molecular & Cellular Proteomics. 4:483-491

Several studies have demonstrated an association between high tumor tissue levels of total tissue inhibitor of metalloproteinases-1 (TIMP-1) and a poor prognosis of primary breast cancer patients. In the present study we investigated whether measurem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b50bd712b7938ea7a7dba907afac8a
https://doi.org/10.1074/mcp.m400209-mcp200