Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ulrik Bølcho"'
Autor:
Lasse Reimer, Louise Buur Vesterager, Cristine Betzer, Jin Zheng, Lærke Dalsgaard Nielsen, Rikke Hahn Kofoed, Louise Berkhoudt Lassen, Ulrik Bølcho, Søren Riis Paludan, Karina Fog, Poul Henning Jensen
Publikováno v:
Neurobiology of Disease, Vol 115, Iss , Pp 17-28 (2018)
Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy comprise a group of neurodegenerative diseases termed synucleinopathies. Synucleinopathie are, characterized by presence of inclusion bodies in degenerating brain cells which
Externí odkaz:
https://doaj.org/article/a55a05d6cf0c4422b4066f41ac9bbc06
Autor:
Niels Kjærsgaard Madsen, Plinio C. Casarotto, Alena Salasova, Peter Lund Ovesen, Mads Fuglsang Kjølby, Benedicte Vestergaard, Eero Castrén, Mai Marie Holm, Sadegh Nabavi, Ulrik Bølcho, Juan Carlos Arevalo, Andreea Cornelia Udrea, Mikhail Paveliev, Lilian Kisiswa, Islam Mustafa Galal Faress, Saray Lopez Benito, Anders Nykjaer, Lucie Woloszczukova, Niels Sanderhoff Degn
Background Huntington’s disease (HD) is a fatal neurodegenerative disorder characterized by progressive motor dysfunction and loss of medium spiny neurons (MSNs) in dorsal striatum. Brain-derived neurotrophic factor (BDNF) sustains functionality an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e85c449714c0d1114a7bb45591f5b6a9
https://doi.org/10.21203/rs.3.rs-1086596/v1
https://doi.org/10.21203/rs.3.rs-1086596/v1
Autor:
Alena Salašová, Niels Sanderhoff Degn, Mikhail Paveliev, Niels Kjærgaard Madsen, Saray López Benito, Plinio Casarotto, Peter Lund Ovesen, Benedicte Vestergaard, Andreea Cornelia Udrea, Lilian Kisiswa, Lucie Woloszczuková, Islam Faress, Sadegh Nabavi, Eero Castrén, Juan Carlos Arévalo, Mai Marie Holm, Mads Fuglsang Kjølby, Ulrik Bølcho, Anders Nykjaer
BackgroundHuntington’s disease (HD) is a fatal neurodegenerative disorder characterized by progressive motor dysfunction and loss of medium spiny neurons (MSNs) in dorsal striatum. Brain-derived neurotrophic factor (BDNF) sustains functionality and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c8773065dbf200d9bfabb28e28fce1a
https://doi.org/10.1101/2021.11.03.466767
https://doi.org/10.1101/2021.11.03.466767
Autor:
Ulrik Bølcho, Katrine B. Andersen, Anders Nykjaer, Morten Skovgaard Jensen, Mai Marie Holm, Sarah Riis, Gitte Bundgaard Christiansen
Publikováno v:
Hippocampus. 27:235-248
Correct function of glutamate receptors in the postsynaptic density is crucial to synaptic function and plasticity. SorCS3 (sortilin-related receptor CNS expressed 3) is a sorting receptor which previously has been shown to interact with the key post
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ddd8c3b843a1e817b46752ea8c28526
https://doi.org/10.1002/hipo.22689
https://doi.org/10.1002/hipo.22689
Autor:
Andrew H. Smith, Ulrik Bølcho, Christian Bjerggaard Vaegter, Jens R. Nyengaard, Anders Nykjaer, Kimmo Jensen, Thomas E. Willnow, S Bøggild, Simon Glerup, Simon Molgaard, L F Pedersen, Mai Marie Holm, Mads Kjolby, P L Ovesen, Hande Login, Olav M. Andersen, Anja W. Fjorback, Jose Luis Nieto-Gonzalez
Publikováno v:
Glerup, S, Bolcho, U, Bøggild, S, Vaegter, C B, Smith, A H, Nieto-Gonzalez, J L, Ovesen, P L, Pedersen, L F, Fjorback, A N, Kjolby, M, Login, H, Holm, M M, Andersen, O M, Nyengaard, J R, Willnow, T E, Jensen, K, Nykjaer, A & Jensen, S M 2016, ' SorCS2 is required for BDNF-dependent plasticity in the hippocampus ', Molecular Psychiatry . https://doi.org/10.1038/mp.2016.108
SorCS2 is a member of the Vps10p-domain receptor gene family receptors with critical roles in the control of neuronal viability and function. Several genetic studies have suggested SORCS2 to confer risk of bipolar disorder, schizophrenia and attentio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df9bd8c77313960491ff21c27c9835d
https://doi.org/10.1038/mp.2016.108
https://doi.org/10.1038/mp.2016.108
Autor:
Rikke Hahn Kofoed, Louise Buur Vesterager, Ulrik Bølcho, Jin Zheng, Poul Henning Jensen, Lærke Dalsgaard Nielsen, Søren R. Paludan, Cristine Betzer, Lasse Reimer, Louise Berkhoudt Lassen, Karina Fog
Publikováno v:
Reimer, L, Lund, L B, Betzer, C, Zheng, J, Nielsen, L D, Kofoed, R H, Lassen, L B, Bølcho, U, Paludan, S R, Fog, K & Jensen, P H 2018, ' Inflammation kinase PKR phosphorylates α-synuclein and causes α-synuclein-dependent cell death ', Neurobiology of Disease . https://doi.org/10.1016/j.nbd.2018.03.001
Neurobiology of Disease, Vol 115, Iss, Pp 17-28 (2018)
Neurobiology of Disease, Vol 115, Iss, Pp 17-28 (2018)
Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy comprise a group of neurodegenerative diseases termed synucleinopathies. Synucleinopathie are, characterized by presence of inclusion bodies in degenerating brain cells which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203238d35db7936ea5ccade5ee86f6eb
https://pubmed.ncbi.nlm.nih.gov/29501855
https://pubmed.ncbi.nlm.nih.gov/29501855
Autor:
Tommy N. Johansen, Giovanna Postorino, Anders A. Jensen, Ulrik Bølcho, Stine B. Vogensen, Jeremy R. Greenwood, Hans Bräuner-Osborne, Thomas Christesen, Rasmus P. Clausen, Jan Egebjerg
Publikováno v:
Journal of Medicinal Chemistry. 50:4177-4185
Four 2-substituted Tet-AMPA [Tet = tetrazolyl, AMPA = 2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid] analogues were characterized functionally at the homomeric AMPA receptors GluR1i, GluR2Qi, GluR3i, and GluR4i in a Fluo-4/Ca2+ assay. Whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cb79f1736f10f5fea11ca0b380c400
https://doi.org/10.1021/jm070532r
https://doi.org/10.1021/jm070532r
Autor:
Michael Gajhede, Tommy N. Johansen, Ulrik Bølcho, Jette S. Kastrup, Giovanna Postorino, Karla Frydenvang, Jan Egebjerg, Rasmus P. Clausen, Stine B. Vogensen, Jeremy R. Greenwood, Darryl S. Pickering, Povl Krogsgaard-Larsen, Birgitte Nielsen, Bjarke Ebert
Publikováno v:
Journal of Medicinal Chemistry. 50:2408-2414
Replacement of the methyl group of the AMPA receptor agonist 2-amino-3-[3-hydroxy-5-(2-methyl-2H-5-tetrazolyl)-4-isoxazolyl]propionic acid (2-Me-Tet-AMPA) with a benzyl group provided the first AMPA receptor agonist, compound 7, capable of discrimina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a45e569c0f62a46f95bea98afc3041a
https://doi.org/10.1021/jm061439q
https://doi.org/10.1021/jm061439q
Autor:
Ulrik Bølcho, Henry R. Kranzler, Nancy Diazgranados, Hongyu Zhao, Andrew H. Smith, Peter Lund Ovesen, Joel Gelernter, David Goldman, Lindsay A. Farrer, Anders Nykjaer, Kevin P. Jensen, Chureerat Phokaew, Seungeun Yeo, Simon Glerup
Publikováno v:
International Journal of Neuropsychopharmacology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019122e91bf9c552a31959693758413a
https://doi.org/10.1093/ijnp/pyw041.296
https://doi.org/10.1093/ijnp/pyw041.296
Publikováno v:
ChemMedChem. 1(4)
Polyamine toxins, such as philanthotoxins, are low-molecular-weight compounds isolated from spiders and wasps, which modulate ligand-gated ion channels in the nervous system. Philanthotoxins bind to the pore-forming region of AMPA receptors, a subtyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525bccdcab57146f9279c01180649066
https://pubmed.ncbi.nlm.nih.gov/16892377
https://pubmed.ncbi.nlm.nih.gov/16892377