A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis

Autor: Yibo He, Changrong Ge, Àlex Moreno-Giró, Bingze Xu, Christian M. Beusch, Katalin Sandor, Jie Su, Lei Cheng, Erik Lönnblom, Christina Lundqvist, Linda M. Slot, Dongmei Tong, Vilma Urbonaviciute, Bibo Liang, Taotao Li, Gonzalo Fernandez Lahore, Mike Aoun, Vivianne Malmström, Theo Rispens, Patrik Ernfors, Camilla I. Svensson, Hans Ulrich Scherer, René E. M. Toes, Inger Gjertsson, Olov Ekwall, Roman A. Zubarev, Rikard Holmdahl

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

Abstract Although elevated levels of anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA), the in vivo functions of these antibodies remain unclear. Here, we have expressed monoclonal ACPAs derived from patients w

Externí odkaz: https://doaj.org/article/7b376f73d800450f955918dee2fa82ac

Randomized phase I trial of antigen-specific tolerizing immunotherapy with peptide/calcitriol liposomes in ACPA+ rheumatoid arthritis

Autor: Amee Sonigra, Hendrik J. Nel, Pascale Wehr, Nishta Ramnoruth, Swati Patel, Karin A. van Schie, Maxwell W. Bladen, Ahmed M. Mehdi, Joanne Tesiram, Meghna Talekar, Jamie Rossjohn, Hugh H. Reid, Frederik E. Stuurman, Helen Roberts, Phillip Vecchio, Ian Gourley, Mark Rigby, Stephane Becart, Rene E.M. Toes, Hans Ulrich Scherer, Kim-Anh Lê Cao, Kim Campbell, Ranjeny Thomas

Publikováno v: JCI Insight, Vol 7, Iss 20 (2022)

BACKGROUND Antigen-specific regulation of autoimmune disease is a major goal. In seropositive rheumatoid arthritis (RA), T cell help to autoreactive B cells matures the citrullinated (Cit) antigen-specific immune response, generating RA-specific V do

Externí odkaz: https://doaj.org/article/25d3db325866461e8778f8d46b427806

Autologous stem cell transplantation for progressive systemic sclerosis: a prospective non-interventional study from the European Society for Blood and Marrow Transplantation Autoimmune Disease Working Party

Autor: Joerg Henes, Maria Carolina Oliveira, Myriam Labopin, Manuela Badoglio, Hans Ulrich Scherer, Nicoletta Del Papa, Thomas Daikeler, Marc Schmalzing, Roland Schroers, Thierry Martin, Gregory Pugnet, Belinda Simoes, David Michonneau, Erik W.A. Marijt, Bruno Lioure, Jacques Olivier Bay, John A. Snowden, Montserrat Rovira, Anne Huynh, Francesco Onida, Lothar Kanz, Zora Marjanovic, Dominique Farge

Publikováno v: Haematologica, Vol 106, Iss 2 (2020)

Three randomized controlled trials in early severe systemic sclerosis demonstrated that autologous hematopoietic stem cell transplantation was superior to standard cyclophosphamide therapy. This European Society for Blood and Marrow Transplantation m

Externí odkaz: https://doaj.org/article/82acc45b2d8b4b39988c40b27598690c

Progression from suspected to definite systemic sclerosis and the role of anti-topoisomerase I antibodies

Autor: Sophie I E Liem, Sam Neppelenbroek, Cynthia M Fehres, Brigitte A Wevers, René E M Toes, Cornelia F Allaart, Tom W J Huizinga, Hans Ulrich Scherer, Jeska K De Vries-Bouwstra

Publikováno v: RMD Open, 9(1). BMJ PUBLISHING GROUP
RMD open, 9(1). BMJ Publishing Group

IntroductionEarly diagnosis of systemic sclerosis (SSc) is important to start therapeutic interventions timely. Important risk factors for progression to SSc are the SSc-specific autoantibodies, of whom anti-centromere antibodies (ACA) and anti-topoi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104b6461f90415478883ad3ecd3c890b
https://hdl.handle.net/1887/3571909

Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation

Autor: Theresa Kissel, Changrong Ge, Lise Hafkenscheid, Joanneke C. Kwekkeboom, Linda M. Slot, Marco Cavallari, Yibo He, Karin A. van Schie, Rochelle D. Vergroesen, Arieke S.B. Kampstra, Sanne Reijm, Gerrie Stoeken-Rijsbergen, Carolien Koeleman, Lennard M. Voortman, Laura H. Heitman, Bingze Xu, Ger J.M. Pruijn, Manfred Wuhrer, Theo Rispens, Tom W.J. Huizinga, Hans Ulrich Scherer, Michael Reth, Rikard Holmdahl, Rene E.M. Toes

Publikováno v: Science Advances, 8, 6, pp. 1-21
Science Advances, 8, 1-21
Science advances, 8(6):abm1759. American Association for the Advancement of Science
Kissel, T, Ge, C, Hafkenscheid, L, Kwekkeboom, J C, Slot, L M, Cavallari, M, He, Y, van Schie, K A, Vergroesen, R D, Kampstra, A S B, Reijm, S, Stoeken-Rijsbergen, G, Koeleman, C, Voortman, L M, Heitman, L H, Xu, B, Pruijn, G J M, Wuhrer, M, Rispens, T, Huizinga, T W J, Scherer, H U, Reth, M, Holmdahl, R & Toes, R E M 2022, ' Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation ', Science Advances, vol. 8, no. 6, abm1759 . https://doi.org/10.1126/sciadv.abm1759
Science Advances, 8(6). AMER ASSOC ADVANCEMENT SCIENCE
Science Advances, 8(6), 1-21

The hallmark autoantibodies in rheumatoid arthritis are characterized by variable domain glycans (VDGs). Their abundant occurrence results from the selective introduction of N-linked glycosylation sites during somatic hypermutation, and their presenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0208285deb500549af186c437aedd773
https://repository.ubn.ru.nl/handle/2066/248660