Zobrazeno 1 - 10
of 407
pro vyhledávání: '"Ulrich Schüller"'
Autor:
Shweta Godbole, Hannah Voß, Antonia Gocke, Simon Schlumbohm, Yannis Schumann, Bojia Peng, Martin Mynarek, Stefan Rutkowski, Matthias Dottermusch, Mario M. Dorostkar, Andrey Korshunov, Thomas Mair, Stefan M. Pfister, Marcel Kwiatkowski, Madlen Hotze, Philipp Neumann, Christian Hartmann, Joachim Weis, Friederike Liesche-Starnecker, Yudong Guan, Manuela Moritz, Bente Siebels, Nina Struve, Hartmut Schlüter, Ulrich Schüller, Christoph Krisp, Julia E. Neumann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically heterogenous. The application of omics technologies—mainly studying nucleic acids—has significantly improved MB classification and stratifica
Externí odkaz:
https://doaj.org/article/675fc26a61af443188a119d2062987c2
Autor:
Jürgen Hench, Claus Hultschig, Jon Brugger, Luigi Mariani, Raphael Guzman, Jehuda Soleman, Severina Leu, Miles Benton, Irenäus Maria Stec, Ivana Bratic Hench, Per Hoffmann, Patrick Harter, Katharina J Weber, Anne Albers, Christian Thomas, Martin Hasselblatt, Ulrich Schüller, Lisa Restelli, David Capper, Ekkehard Hewer, Joachim Diebold, Danijela Kolenc, Ulf C. Schneider, Elisabeth Rushing, Rosa della Monica, Lorenzo Chiariotti, Martin Sill, Daniel Schrimpf, Andreas von Deimling, Felix Sahm, Christian Kölsche, Markus Tolnay, Stephan Frank
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract DNA methylation analysis based on supervised machine learning algorithms with static reference data, allowing diagnostic tumour typing with unprecedented precision, has quickly become a new standard of care. Whereas genome-wide diagnostic me
Externí odkaz:
https://doaj.org/article/0728b5481b5942bf8a38046de711832e
Autor:
Richard Drexler, Florian Brembach, Jennifer Sauvigny, Franz L. Ricklefs, Alicia Eckhardt, Helena Bode, Jens Gempt, Katrin Lamszus, Manfred Westphal, Ulrich Schüller, Malte Mohme
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-8 (2024)
Abstract DNA methylation analysis has become a powerful tool in neuropathology. Although DNA methylation-based classification usually shows high accuracy, certain samples cannot be classified and remain clinically challenging. We aimed to gain insigh
Externí odkaz:
https://doaj.org/article/148f558c75074ac9829fbfc45b1d8605
Autor:
Carolin Göbel, Shweta Godbole, Melanie Schoof, Dörthe Holdhof, Catena Kresbach, Carolin Loose, Julia Neumann, Ulrich Schüller
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-13 (2023)
Abstract Group 3 medulloblastoma is one of the most aggressive types of childhood brain tumors. Roughly 30% of cases carry genetic alterations in MYC, SMARCA4, or both genes combined. While overexpression of MYC has previously been shown to drive med
Externí odkaz:
https://doaj.org/article/234db635bc2b43d68c70869f656e3164
Autor:
Melanie Schoof, Shweta Godbole, Thomas K. Albert, Matthias Dottermusch, Carolin Walter, Annika Ballast, Nan Qin, Marlena Baca Olivera, Carolin Göbel, Sina Neyazi, Dörthe Holdhof, Catena Kresbach, Levke-Sophie Peter, Gefion Dorothea Epplen, Vanessa Thaden, Michael Spohn, Mirjam Blattner-Johnson, Franziska Modemann, Martin Mynarek, Stefan Rutkowski, Martin Sill, Julian Varghese, Ann-Kristin Afflerbach, Alicia Eckhardt, Daniel Münter, Archana Verma, Nina Struve, David T. W. Jones, Marc Remke, Julia E. Neumann, Kornelius Kerl, Ulrich Schüller
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Pediatric high-grade gliomas of the subclass MYCN (HGG-MYCN) are highly aggressive tumors frequently carrying MYCN amplifications, TP53 mutations, or both alterations. Due to their rarity, such tumors have only recently been identified as a
Externí odkaz:
https://doaj.org/article/09d9e0ef2e924a438dede74c6b3805ed
Autor:
Viktoria L. E. Funke, Sarah Sandmann, Viktoria Melcher, Jochen Seggewiss, Judit Horvath, Natalie Jäger, Marcel Kool, David T. W. Jones, Stefan M. Pfister, Till Milde, Stefan Rutkowski, Martin Mynarek, Julian Varghese, Ronald Sträter, Stephan Rust, Anja Seelhöfer, Janine Reunert, Barbara Fiedler, Ulrich Schüller, Thorsten Marquardt, Kornelius Kerl
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-4 (2023)
Abstract To date, several studies on genomic events underlying medulloblastoma (MB) biology have expanded our understanding of this tumour entity and led to its division into four groups—WNT, SHH, group 3 (G3) and group 4 (G4). However, there is li
Externí odkaz:
https://doaj.org/article/4d42ac6cc3f343f1a26382b1265c71a1
The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice
Autor:
Melanie Schoof, Gefion Dorothea Epplen, Carolin Walter, Annika Ballast, Dörthe Holdhof, Carolin Göbel, Sina Neyazi, Julian Varghese, Thomas Karl Albert, Kornelius Kerl, Ulrich Schüller
Publikováno v:
Oncogenesis, Vol 12, Iss 1, Pp 1-11 (2023)
Abstract The tumor suppressor and chromatin modifier cAMP response element-binding protein binding protein (CREBBP) and v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN), a member of the MYC oncogene family, are critica
Externí odkaz:
https://doaj.org/article/b15682d4e3694e03b88707ff4e3a4985
Autor:
Mohamed E. Elsesy, Su Jung Oh‐Hohenhorst, Christoph Oing, Alicia Eckhardt, Susanne Burdak‐Rothkamm, Malik Alawi, Christian Müller, Ulrich Schüller, Tobias Maurer, Gunhild vonAmsberg, Cordula Petersen, Kai Rothkamm, Wael Y. Mansour
Publikováno v:
Molecular Oncology, Vol 17, Iss 6, Pp 1129-1147 (2023)
The use of mutation analysis of homologous recombination repair (HRR) genes to estimate PARP‐inhibition response may miss a larger proportion of responding patients. Here, we provide preclinical models for castration‐resistant prostate cancer (CR
Externí odkaz:
https://doaj.org/article/de640423cfee4a5e9ddaf1dec52ce8c8
Autor:
Viktoria L. E. Funke, Carolin Walter, Viktoria Melcher, Lanying Wei, Sarah Sandmann, Marc Hotfilder, Julian Varghese, Natalie Jäger, Marcel Kool, David T. W. Jones, Stefan M. Pfister, Till Milde, Martin Mynarek, Stefan Rutkowski, Jochen Seggewiss, Daniela Jeising, Flavia W. de Faria, Thorsten Marquardt, Thomas K. Albert, Ulrich Schüller, Kornelius Kerl
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Cancer metabolism influences multiple aspects of tumorigenesis and causes diversity across malignancies. Although comprehensive research has extended our knowledge of molecular subgroups in medulloblastoma (MB), discrete analysis
Externí odkaz:
https://doaj.org/article/293ede42057e4448bff90666e15848b1
Autor:
Felix K. F. Kommoss, Anne-Sophie Chong, Anne-Laure Chong, Elke Pfaff, David T. W. Jones, Laura S. Hiemcke-Jiwa, Lennart A. Kester, Uta Flucke, Manfred Gessler, Daniel Schrimpf, Felix Sahm, Blaise A. Clarke, Colin J. R. Stewart, Yemin Wang, C. Blake Gilks, Friedrich Kommoss, David G. Huntsman, Ulrich Schüller, Christian Koelsche, W. Glenn McCluggage, Andreas von Deimling, William D. Foulkes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
DICER1 syndrome is associated with a predisposition to multiple tumor types. Here, the authors identify and characterize 3 molecular subgroups of mesenchymal tumors with DICER1 mutations.
Externí odkaz:
https://doaj.org/article/a05486ab7360425590af6bdea112612d