Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ulrich Rass"'
Autor:
Gabriele A. Fontana, Daniel Hess, Julia K. Reinert, Stefano Mattarocci, Benoît Falquet, Dominique Klein, David Shore, Nicolas H. Thomä, Ulrich Rass
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Rif1 is involved in different processes such as telomere homeostasis, DNA replication timing, and DNA double strand break (DSB) repair pathway choice. Here, the authors reveal that Rif1 S-acylation facilitates the accumulation of Rif1 at DSBs, attenu
Externí odkaz:
https://doaj.org/article/5cf20ca662034689ad49ccb51a846d04
Autor:
Mario Alberto Flores-Valdez, Gabriele A. Fontana, Julia K. Reinert, Nicolas H. Thomä, Ulrich Rass
Publikováno v:
Microbial Cell, Vol 5, Iss 7, Pp 327-343 (2018)
Cells have evolved conserved mechanisms to protect DNA ends, such as those at the termini of linear chromosomes, or those at DNA double-strand breaks (DSBs). In eukaryotes, DNA ends at chromosomal termini are packaged into proteinaceous structures ca
Externí odkaz:
https://doaj.org/article/e0ae7b362ed848aa84340d643a0783f4
Autor:
Gabriele A. Fontana, Ulrich Rass
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 6 (2019)
DNA double-strand breaks (DSBs) disrupt the structural integrity of chromosomes. Proper DSB repair pathway choice is critical to avoid the type of gross chromosomal rearrangements that characterize cancer cells. Recent findings reveal S-fatty acylati
Externí odkaz:
https://doaj.org/article/c7fecd648ca6475cb7286164b5f9acc7
Autor:
Jessica J. R. Hudson, Ulrich Rass
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 3984 (2021)
The conserved nuclease-helicase DNA2 has been linked to mitochondrial myopathy, Seckel syndrome, and cancer. Across species, the protein is indispensable for cell proliferation. On the molecular level, DNA2 has been implicated in DNA double-strand br
Externí odkaz:
https://doaj.org/article/eb1e4cc0ffb748999259dbe875fd39f0
Autor:
Gizem Ölmezer, Maryna Levikova, Dominique Klein, Benoît Falquet, Gabriele Alessandro Fontana, Petr Cejka, Ulrich Rass
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
DNA replication stress drives genome instability and cancer. Here, Ölmezer and colleagues show that the helicase activity of multifunctional enzyme Dna2 suppresses dead-end replication structures that impair chromosome segregation if not removed by
Externí odkaz:
https://doaj.org/article/2367aeec710c456184e031a5d8069fa2
Autor:
Benoît Falquet, Ulrich Rass
Publikováno v:
Microbial Cell, Vol 4, Iss 1, Pp 32-34 (2017)
DNA replication is mediated by a multi-protein complex known as the replisome. With the hexameric MCM (minichromosome maintenance) replicative helicase at its core, the replisome splits the parental DNA strands, forming replication forks (RFs), where
Externí odkaz:
https://doaj.org/article/e292a4fd24914de3b6d49f9d0b405927
Publikováno v:
Current Genetics
The disease-associated nuclease–helicase DNA2 has been implicated in DNA end-resection during DNA double-strand break repair, Okazaki fragment processing, and the recovery of stalled DNA replication forks (RFs). Its role in Okazaki fragment process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d082a4d31df73007b57d8b0ed5bdb7f
https://doi.org/10.1007/s00294-020-01106-7
https://doi.org/10.1007/s00294-020-01106-7
Autor:
Ulrich Rass, Jessica Hudson
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 3984, p 3984 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 3984, p 3984 (2021)
The conserved nuclease-helicase DNA2 has been linked to mitochondrial myopathy, Seckel syndrome, and cancer. Across species, the protein is indispensable for cell proliferation. On the molecular level, DNA2 has been implicated in DNA double-strand br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b261e814ce52cd0aca90f9f318aae7
http://europepmc.org/articles/PMC8069077
http://europepmc.org/articles/PMC8069077
Autor:
Benoît Falquet, Franz Enkner, Kiran Challa, Rowin Appanah, Dominique Klein, Ulrich Rass, Susan M. Gasser, Gizem Ölmezer
Publikováno v:
Nucleic Acids Research
DNA2 is an essential nuclease–helicase implicated in DNA repair, lagging-strand DNA synthesis, and the recovery of stalled DNA replication forks (RFs). In Saccharomyces cerevisiae, dna2Δ inviability is reversed by deletion of the conserved helicas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d8e3723fe2436c8e4edc426660711f
https://doi.org/10.1093/nar/gkaa524
https://doi.org/10.1093/nar/gkaa524
Publikováno v:
Microbial Cell
Microbial Cell, Vol 5, Iss 7, Pp 327-343 (2018)
Microbial Cell, Vol 5, Iss 7, Pp 327-343 (2018)
Cells have evolved conserved mechanisms to protect DNA ends, such as those at the termini of linear chromosomes, or those at DNA double-strand breaks (DSBs). In eukaryotes, DNA ends at chromosomal termini are packaged into proteinaceous structures ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af593beac0222ed0ab000b694bdfc9c3
https://doi.org/10.15698/mic2018.07.639
https://doi.org/10.15698/mic2018.07.639