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Akademický článek

Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1

Autor: Katrin Hipke, Bettina Pitter, Alexander Hruscha, Frauke van Bebber, Miha Modic, Vikas Bansal, Sebastian A. Lewandowski, Denise Orozco, Dieter Edbauer, Stefan Bonn, Christian Haass, Ulrich Pohl, Eloi Montanez, Bettina Schmid

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Aggregation of the Tar DNA-binding protein of 43 kDa (TDP-43) is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia and likely contributes to disease by loss of nuclear function. Analysis of TDP-43 function in knocko

Externí odkaz: https://doaj.org/article/41783c87576d4c5381ad20b7824e8c6c

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Akademický článek

Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in SepsisResearch in context

Autor: Yvonn Heun, Joachim Pircher, Thomas Czermak, Philipp Bluem, Georg Hupel, Monica Bohmer, Bjoern F. Kraemer, Kristin Pogoda, Alexander Pfeifer, Markus Woernle, Andrea Ribeiro, Max Hübner, Simone Kreth, Ralf A. Claus, Sebastian Weis, Luisa Ungelenk, Florian Krötz, Ulrich Pohl, Hanna Mannell

Publikováno v: EBioMedicine, Vol 42, Iss , Pp 120-132 (2019)

Background: Sepsis, the most severe form of infection, involves endothelial dysfunction which contributes to organ failure. To improve therapeutic prospects, elucidation of molecular mechanisms underlying endothelial vascular failure is of essence. M

Externí odkaz: https://doaj.org/article/78b587040038484299b00611b43f6d90

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Akademický článek

Long-term functional and structural preservation of precision-cut human myocardium under continuous electromechanical stimulation in vitro

Autor: Carola Fischer, Hendrik Milting, Evelyn Fein, Elisabeth Reiser, Kun Lu, Thomas Seidel, Camilla Schinner, Thomas Schwarzmayr, Rene Schramm, Roland Tomasi, Britta Husse, Xiaochun Cao-Ehlker, Ulrich Pohl, Andreas Dendorfer

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Myocardial tissue undergoes steady functional decline when cultured in vitro. Here, the authors report a protocol for culture of human cardiac slices that allows maintenance of contractility for up to four months, and show that the model is suitable

Externí odkaz: https://doaj.org/article/b0d54360a0484bdfbbb91bce79c8f903

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Akademický článek

Publisher Correction: Long-term functional and structural preservation of precision-cut human myocardium under continuous electromechanical stimulation in vitro

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)

The original version of this Article incorrectly acknowledged Elisabeth Reiser and Rene Schramm as a corresponding author. This has now been corrected in both the PDF and HTML versions of the Article.

Externí odkaz: https://doaj.org/article/bc54a4c4a8224ab2b9743e16baaef3b9

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Akademický článek

Label-free determination of hemodynamic parameters in the microcirculaton with third harmonic generation microscopy.

Autor: Steffen Dietzel, Joachim Pircher, A Katharina Nekolla, Mazhar Gull, André W Brändli, Ulrich Pohl, Markus Rehberg

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e99615 (2014)

Determination of blood flow velocity and related hemodynamic parameters is an important aspect of physiological studies which in many settings requires fluorescent labeling. Here we show that Third Harmonic Generation (THG) microscopy is a suitable t

Externí odkaz: https://doaj.org/article/832d8d5c1b2e4f1495074f95fdf9353e

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Akademický článek

Visualization of endothelial actin cytoskeleton in the mouse retina.

Autor: Alessia Fraccaroli, Claudio A Franco, Emanuel Rognoni, Filipa Neto, Markus Rehberg, Attila Aszodi, Roland Wedlich-Söldner, Ulrich Pohl, Holger Gerhardt, Eloi Montanez

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47488 (2012)

Angiogenesis requires coordinated changes in cell shape of endothelial cells (ECs), orchestrated by the actin cytoskeleton. The mechanisms that regulate this rearrangement in vivo are poorly understood - largely because of the difficulty to visualize

Externí odkaz: https://doaj.org/article/314855a24cc84f8cac746bbbb72d33e5

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Akademický článek

Label-free 3D visualization of cellular and tissue structures in intact muscle with second and third harmonic generation microscopy.

Autor: Markus Rehberg, Fritz Krombach, Ulrich Pohl, Steffen Dietzel

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e28237 (2011)

Second and Third Harmonic Generation (SHG and THG) microscopy is based on optical effects which are induced by specific inherent physical properties of a specimen. As a multi-photon laser scanning approach which is not based on fluorescence it combin

Externí odkaz: https://doaj.org/article/8e8ce448c4cd4c2681313e67605f7c5f

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Cx43 Promotes Endothelial Cell Migration and Angiogenesis via the Tyrosine Phosphatase SHP-2

Autor: Hanna Mannell, Petra Kameritsch, Heike Beck, Alexander Pfeifer, Ulrich Pohl, Kristin Pogoda

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 294
International Journal of Molecular Sciences, Vol 23, Iss 294, p 294 (2022)

The gap junction protein connexin 43 (Cx43) is associated with increased cell migration and to related changes of the actin cytoskeleton, which is mediated via its C-terminal cytoplasmic tail and is independent of its channel function. Cx43 has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db723b7d96ce6f9ea1591bd7a84945ef
http://europepmc.org/articles/PMC8745637

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