Výsledky vyhledávání - "Ulrich Patzak"

Identification and Quantitation of theN-Acetyl-L-cysteineS-Conjugates of Bendamustine and Its Sulfoxides in Human Bile after Administration of Bendamustine Hydrochloride

Autor: Jens Teichert, Frank Baumann, Lothar Hennig, Reinhard Sohr, Ulrich Patzak, Rainer Preiss, K. Schoppmeyer

Publikováno v: Drug Metabolism and Disposition. 37:292-301

We recently reported the detection of mercapturic acid pathway metabolites of bendamustine, namely, cysteine S-conjugates in human bile, which are supposed to subsequently undergo further metabolism. In this study, we describe the identification and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4f2d89cf1737d95c5bfe4d52a13792
https://doi.org/10.1124/dmd.108.022855

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Characterization of two phase I metabolites of bendamustine in human liver microsomes and in cancer patients treated with bendamustine hydrochloride

Autor: Frank Baumann, Karel Caca, Jens Teichert, Craig Franklin, Lothar Hennig, Rainer Preiss, K. Schoppmeyer, Brandy Bailey, Ulrich Patzak, Qi Chao

Publikováno v: Cancer Chemotherapy and Pharmacology. 59:759-770

The metabolism of bendamustine (BM) hydrochloride, a bifunctional alkylator containing a heterocyclic ring, was investigated in vitro and in vivo for identification of cytochromes P450 (CYP) involved in the formation of two phase I metabolites, struc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d043640dad2a1a33787644817c35422
https://doi.org/10.1007/s00280-006-0331-5

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Urinary Excretion and Metabolism of Arbutin after Oral Administration of Arctostaphylos uvae ursi Extract as Film-Coated Tablets and Aqueous Solution in Healthy Humans

Autor: G Schindler, Markus Veit, Jörg Wittig, Ulrich Patzak, Nils Krähmer, B Brinkhaus, Ingmar Glöckl, Alexander Von Nieciecki

Publikováno v: The Journal of Clinical Pharmacology. 42:920-927

Bearberry leaves and preparations made from them are traditionally used for urinary tract infections. The urinary excretion of arbutin metabolites was examined in a randomized crossover design in 16 healthy volunteers after the application of a singl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21d6e4ce31176fdab51e4e7b6668133
https://doi.org/10.1177/009127002401102740

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