Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ulrich Nielsch"'
This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug dis
Publikováno v:
Handbook of experimental pharmacology. 232
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783319289120
New Approaches to Drug Discovery
New Approaches to Drug Discovery
Preface.- Part 1. Historical View.- Drug discovery in the past and today.Part 2. Target Discovery.- Emerging target families: intractable targets. In vivo target validation especially for biological targets. HR RNAi/High Content analysis.- Part 3. Le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35f414de03e301e28ec0ff7e4140112f
https://doi.org/10.1007/978-3-319-28914-4
https://doi.org/10.1007/978-3-319-28914-4
Publikováno v:
Drug Discovery Today. 12:1025-1031
Ever-increasing research and development costs are putting constant pressure on the pharmaceutical industry to improve their efficiency. Efforts to increase the output of the research pipeline have yielded limited success. Traditionally, maximization
Autor:
Ursula Ravens, Peter Ellinghaus, Juergen Holtz, Ulrich Nielsch, Henning Morawietz, Joachim Huetter, Dobromir Dobrev, RJ Scheubel
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 129(6):1383-1390
Objectives The knowledge of chamber-specific gene expression in human atrial and ventricular myocardium is essential for the understanding of myocardial function and the basis for the identification of putative therapeutic targets in the treatment of
Autor:
Michael Hörtner, Lorenz M. Mayr, Serge Haan, Ulrich Nielsch, Peter C. Heinrich, James A. Johnston
Publikováno v:
The Journal of Immunology. 169:1219-1227
G-CSF is a polypeptide growth factor used in treatment following chemotherapy. G-CSF regulates granulopoiesis and acts on its target cells by inducing homodimerization of the G-CSFR, thereby activating intracellular signaling cascades. The G-CSFR enc
Publikováno v:
European Journal of Biochemistry. 269:2516-2526
Erythropoietin (Epo) is a hematopoietic cytokine that is crucial for the differentiation and proliferation of erythroid progenitor cells. Epo acts on its target cells by inducing homodimerization of the erythropoietin receptor (EpoR), thereby trigger
Autor:
Michael Sperzel, Christoph Gerdes, Ulrich Nielsch, Klemens Lustig, Berthold Hinzen, Gabriele Bräunlich, Josef Pernerstorfer, Thomas Kramer
Publikováno v:
Handbook of Combinatorial Chemistry: Drugs, Catalysts, Materials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4252dc12e9d908da2095f1ac831f1416
https://doi.org/10.1002/3527603034.ch28
https://doi.org/10.1002/3527603034.ch28
Autor:
Berthold Hinzen, Gabriele Braunlich, Christoph Gerdes, Thomas Kramer, Klemens Lustig, Ulrich Nielsch, Michael Sperzel, Josef Pernerstorfer
Publikováno v:
ChemInform. 35
Publikováno v:
European journal of biochemistry. 269(10)
Erythropoietin (Epo) is a hematopoietic cytokine that is crucial for the differentiation and proliferation of erythroid progenitor cells. Epo acts on its target cells by inducing homodimerization of the erythropoietin receptor (EpoR), thereby trigger