Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Ulrich Misgeld"'
Publikováno v:
The Journal of Physiology. 577:879-890
A phasic activation of small-conductance Ca(2+)-dependent K(+) channels (SK channels) underlies spike-afterhyperpolarizations and spike-independent, transient hyperpolarizations in juvenile substantia nigra neurons. Outward current pulses that cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3b8d5f02e3b25fe323d6019cfadc01d
https://doi.org/10.1113/jphysiol.2006.117622
https://doi.org/10.1113/jphysiol.2006.117622
Publikováno v:
European Journal of Neuroscience. 23:454-464
The Cl(-)-extruding neuron-specific K(+)-Cl(-) cotransporter KCC2, which establishes hyperpolarizing inhibition, can transport NH(4) (+) instead of K(+). It is, however, not clear whether KCC2 provides the only pathway for neuronal NH(4) (+) uptake.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f612b7cba7d25c9deef8892cc9d9ed34
https://doi.org/10.1111/j.1460-9568.2005.04583.x
https://doi.org/10.1111/j.1460-9568.2005.04583.x
Publikováno v:
Neuroscience. 137:337-361
Endocannabinoids, acting via type 1 cannabinoid receptors (CB1), are known to be involved in short-term synaptic plasticity via retrograde signaling. Strong depolarization of the postsynaptic neurons is followed by the endocannabinoid-mediated activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146bbdc810165a1f0191b7669969d0cd
https://doi.org/10.1016/j.neuroscience.2005.09.005
https://doi.org/10.1016/j.neuroscience.2005.09.005
Publikováno v:
Neuroscience. 136:1027-1036
Neurons in substantia nigra pars reticulata express the messenger RNA for SK2 but not for SK3 subunits that form small-conductance, Ca2+-dependent K+ channels in dopamine neurons. To determine pathways for the activation of small-conductance, Ca2+-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfde0ae5e7be9332e531b49ecd2da0f4
https://doi.org/10.1016/j.neuroscience.2005.08.026
https://doi.org/10.1016/j.neuroscience.2005.08.026
Autor:
Ulrich Misgeld
Publikováno v:
Cell and Tissue Research. 318:107-114
This review describes inputs to neurons in the substantia nigra and contrasts them with the action of agonists for the putative receptors through which they act. Special emphasis is placed on gamma-aminobutyric acid (GABA) afferents. Dopamine release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e6e96ac2cee8c56502464737b42a60
https://doi.org/10.1007/s00441-004-0918-2
https://doi.org/10.1007/s00441-004-0918-2
Hyperpolarizing Inhibition Develops without Trophic support by GABA in Cultured Rat Midbrain Neurons
Publikováno v:
The Journal of Physiology. 550:719-730
During a limited period of early neuronal development, GABA is depolarizing and elevates [Ca2+]i, which mediates the trophic action of GABA in neuronal maturation. We tested the attractive hypothesis that GABA itself promotes the developmental change
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32e46ac2c2a4edf9251d432e315490d
https://doi.org/10.1113/jphysiol.2003.041863
https://doi.org/10.1113/jphysiol.2003.041863
Autor:
Ulrich Misgeld, Yevgenij Yanovsky
Publikováno v:
Epilepsy Research. 52:263-273
Inhibition by GABA B receptors comprises activation of K + conductance and inhibition of Ca 2+ conductance, thereby reducing action potential dependent transmitter release and silencing neuronal activity. We compared epileptiform activity and its inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f0620d8430ffa44bcdb0a997cea27c
https://doi.org/10.1016/s0920-1211(02)00235-8
https://doi.org/10.1016/s0920-1211(02)00235-8
Publikováno v:
Neuroscience Letters
The weaver mutation causes cell loss in the center of the substantia nigra, pars compacta. We compared the depression of γ-aminobutyric acid (GABA) A synaptic currents by the GABA B agonist R-baclofen in pars compacta neurons of weaver mice which we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b2083e3b04bfb8d3adf27cb4db8f56
https://doi.org/10.1016/s0304-3940(01)01496-3
https://doi.org/10.1016/s0304-3940(01)01496-3
Publikováno v:
The Journal of Neuroscience. 19:4695-4704
Efficacy of postsynaptic inhibition through GABAAreceptors in the mammalian brain depends on the maintenance of a Cl−gradient for hyperpolarizing Cl−currents. We have taken advantage of the reduced complexity under which Cl−regulation can be in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb589b86101ed932fc50e4b84325f49
https://doi.org/10.1523/jneurosci.19-12-04695.1999
https://doi.org/10.1523/jneurosci.19-12-04695.1999
Publikováno v:
The Journal of Neuroscience. 18:4001-4007
Weaver(wv) mice carry a point mutation in the pore region of a G-protein-gated inwardly rectifying K+channel subunit (Kir3.2).wvKir3.2 conducts inward currents that may cause the loss of neurons in the cerebellum and substantia nigra. Although Kir3.2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b194400aacbf6f16341f706850a37eb
https://doi.org/10.1523/jneurosci.18-11-04001.1998
https://doi.org/10.1523/jneurosci.18-11-04001.1998