Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Ulrich L. M. Eisel"'
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/09a3648ecdb14ee18017e76577818e04
Autor:
Natalia Ortí-Casañ, Ate S. Boerema, Karina Köpke, Amber Ebskamp, Jan Keijser, Yuequ Zhang, Tingting Chen, Amalia M. Dolga, Kerensa Broersen, Roman Fischer, Klaus Pfizenmaier, Roland E. Kontermann, Ulrich L. M. Eisel
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Tumor necrosis factor alpha (TNF-α) and its key role in modulating immune responses has been widely recognized as a therapeutic target for inflammatory and neurodegenerative diseases. Even though inhibition of TNF-α is beneficial for the t
Externí odkaz:
https://doaj.org/article/c98638b7b125423496722b05327a5864
Autor:
Valentina Pegoretti, Jan Bauer, Roman Fischer, Iskra Paro, Wanda Douwenga, Roland E. Kontermann, Klaus Pfizenmaier, Evelien Houben, Bieke Broux, Niels Hellings, Wia Baron, Jon D. Laman, Ulrich L. M. Eisel
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract TNF signaling is an essential regulator of cellular homeostasis. Through its two receptors TNFR1 and TNFR2, soluble versus membrane-bound TNF enable cell death or survival in a variety of cell types. TNF-TNFRs signaling orchestrates importan
Externí odkaz:
https://doaj.org/article/5841bf7052c54683ab34c56469546a89
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Alzheimer’s disease (AD) and Parkinson’s disease (PD) represent the most prevalent neurodegenerative disorders severely impacting life expectancy and quality of life of millions of people worldwide. AD and PD exhibit both a very distinct pathophy
Externí odkaz:
https://doaj.org/article/f9508b8a457b41cf810e538920be9120
Autor:
Doortje W. Dekens, Petrus J. W. Naudé, Jan N. Keijser, Ate S. Boerema, Peter P. De Deyn, Ulrich L. M. Eisel
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-13 (2018)
Abstract Background Lipocalin 2 (Lcn2) is an acute-phase protein implicated in multiple neurodegenerative conditions. Interestingly, both neuroprotective and neurodegenerative effects have been described for Lcn2. Increased Lcn2 levels were found in
Externí odkaz:
https://doaj.org/article/f4e0a1de15cf45e69d58de7a22a43978
Autor:
Sarah K. Williams, Richard Fairless, Olaf Maier, Patricia C. Liermann, Kira Pichi, Roman Fischer, Ulrich L. M. Eisel, Roland Kontermann, Andreas Herrmann, Babette Weksler, Nacho Romero, Pierre-Olivier Couraud, Klaus Pfizenmaier, Ricarda Diem
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Tumour necrosis factor (TNF) signalling is mediated via two receptors, TNF-receptor 1 (TNFR1) and TNF-receptor 2 (TNFR2), which work antithetically to balance CNS immune responses involved in autoimmune diseases such as multiple sclerosis. T
Externí odkaz:
https://doaj.org/article/1d5fda7e325a49d7ac87de90f8d6525b
Autor:
Natalia Ortí-Casañ, Yingying Wu, Petrus J. W. Naudé, Peter P. De Deyn, Inge S. Zuhorn, Ulrich L. M. Eisel
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. Accumulating experimental evidence shows the important linkage between tumor necrosis factor-α (TNF) and AD, but the exact role of TNF in A
Externí odkaz:
https://doaj.org/article/b25979966f3a451cbf0782759e37c72d
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Autoimmunity develops when self-tolerance mechanisms are failing to protect healthy tissue. A sustained reaction to self is generated, which includes the generation of effector cells and molecules that destroy tissues. A way to restore this intrinsic
Externí odkaz:
https://doaj.org/article/eb18a36473dc42b19a0ebcc955b988d3
Publikováno v:
Antibodies, Vol 4, Iss 4, Pp 369-408 (2015)
Numerous studies have revealed the pleiotropic functions of tumor necrosis factor alpha (TNF-α), and have linked it with several neurodegenerative disorders. This review describes the signaling pathways induced by TNF-α via its two receptors (TNFR1
Externí odkaz:
https://doaj.org/article/d636c07f433341ddbf927f1d8704e0d4
Autor:
Suzanne D. Lanooij, Ulrich L. M. Eisel, Wilhelmus H. I. M. Drinkenburg, Eddy A. van der Zee, Martien J. H. Kas
Publikováno v:
Molecular Psychiatry. :28-33
Many psychiatric and neurological disorders present deficits in both the social and cognitive domain. In this perspectives article, we provide an overview and the potential of the existence of an extensive neurobiological substrate underlying the clo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbd70828834db987b19498406b125a5
https://hdl.handle.net/11370/8adb5f23-2a88-4623-be1c-7c8e7e8a2b68
https://hdl.handle.net/11370/8adb5f23-2a88-4623-be1c-7c8e7e8a2b68