Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ulrich L. Gunther"'
Autor:
Lozan Sheriff, Reenam S. Khan, Raquel Saborano, Richard Wilkin, Nguyet-Thin Luu, Ulrich L. Gunther, Stefan G. Hubscher, Philip N. Newsome, Patricia F. Lalor
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 12 (2020)
Alcoholic hepatitis (AH) is the dramatic acute presentation of alcoholic liver disease, with a 15% mortality rate within 28 days in severe cases. Research into AH has been hampered by the lack of effective and reproducible murine models that can be o
Externí odkaz:
https://doaj.org/article/7c847439e4524eaa9d2cb019ba199e50
Autor:
Tanja Fererberger, Christa Buechler, Arne Kandulski, Tanja Elger, Johanna Loibl, Stephan Schmid, Stefanie Sommersberger, Stefan Gunawan, Sebastian Zundler, Muriel Huss, Dominik Bettenworth, Sally Kempa, Simon Weidlich, Bandik Föh, Xinyu Huang, Marcin Grzegorzek, Stefanie Derer-Petersen, Ulrich L. Günther, Jens U. Marquardt, Claudia Kunst, Karsten Gülow, Martina Müller, Christian Sina, Franziska Schmelter, Hauke C. Tews
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
IntoductionIdentification of specific metabolome and lipidome profile of patients with primary sclerosing cholangitis (PSC) is crucial for diagnosis, targeted personalized therapy, and more accurate risk stratification.MethodsNuclear magnetic resonan
Externí odkaz:
https://doaj.org/article/09253d97ee434a928fe26eb14955b0ba
Autor:
Vesna S. Stanulović, Shorog Al Omair, Michelle A.C. Reed, Jennie Roberts, Sandeep Potluri, Taylor Fulton-Ward, Nancy Gudgeon, Emma L. Bishop, Juliette Roels, Tracey A. Perry, Sovan Sarkar, Guy Pratt, Tom Taghon, Sarah Dimeloe, Ulrich L. Günther, Christian Ludwig, Maarten Hoogenkamp
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
T-cell acute lymphoblastic leukemia (T-ALL) is a cancer of the immune system. Approximately 20% of paediatric and 50% of adult T-ALL patients have refractory disease or relapse and die from the disease. To improve patient outcome new therapeutics are
Externí odkaz:
https://doaj.org/article/89ee5f73be0d42d2909cf64e304355a7
Autor:
Sally Kempa, Christa Buechler, Bandik Föh, Oliver Felthaus, Lukas Prantl, Ulrich L. Günther, Martina Müller, Stefanie Derer-Petersen, Christian Sina, Franziska Schmelter, Hauke C. Tews
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17437 (2023)
Lipedema is a chronic condition characterized by disproportionate and symmetrical enlargement of adipose tissue, predominantly affecting the lower limbs of women. This study investigated the use of metabolomics in lipedema research, with the objectiv
Externí odkaz:
https://doaj.org/article/4cdc4a2e5cb24fd7b4c3a0235a575085
Autor:
Marina Creydt, Friedemann Flügge, Robin Dammann, Burkhard Schütze, Ulrich L. Günther, Markus Fischer
Publikováno v:
Metabolites, Vol 13, Iss 5, p 673 (2023)
Oregano (Origanum vulgare and O. onites) is one of the most frequently counterfeited herbs in the world and is diluted with the leaves of a wide variety of plants. In addition to olive leaves, marjoram (O. majorana) is often used for this purpose in
Externí odkaz:
https://doaj.org/article/75858a8e8c2541a280df33ffed8d569a
Autor:
Albertus T. J. Wierenga, Alan Cunningham, Ayşegül Erdem, Nuria Vilaplana Lopera, Annet Z. Brouwers-Vos, Maurien Pruis, André B. Mulder, Ulrich L. Günther, Joost H. A. Martens, Edo Vellenga, Jan Jacob Schuringa
Publikováno v:
Cancer & Metabolism, Vol 7, Iss 1, Pp 1-17 (2019)
Abstract Background Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic stem and progenitors is conflict
Externí odkaz:
https://doaj.org/article/bc991f9e636e41c6936e5e05d890d9b1
Autor:
Franziska Schmelter, Bandik Föh, Alvaro Mallagaray, Johann Rahmöller, Marc Ehlers, Selina Lehrian, Vera von Kopylow, Inga Künsting, Anne Sophie Lixenfeld, Emily Martin, Mohab Ragab, Roza Meyer-Saraei, Fabian Kreutzmann, Ingo Eitel, Stefan Taube, Nadja Käding, Eckard Jantzen, Tobias Graf, Christian Sina, Ulrich L. Günther
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Coronavirus disease 2019 (COVID-19) is a viral infection affecting multiple organ systems of great significance for metabolic processes. Thus, there is increasing interest in metabolic and lipoprotein signatures of the disease, and early analyses hav
Externí odkaz:
https://doaj.org/article/bbbf11393234463db0d98a3642a824c6
Autor:
Emma L. Shepherd, Raquel Saborano, Ellie Northall, Kae Matsuda, Hitomi Ogino, Hiroaki Yashiro, Jason Pickens, Ryan E. Feaver, Banumathi K. Cole, Stephen A. Hoang, Mark J. Lawson, Matthew Olson, Robert A. Figler, John E. Reardon, Nobuhiro Nishigaki, Brian R. Wamhoff, Ulrich L. Günther, Gideon Hirschfield, Derek M. Erion, Patricia F. Lalor
Publikováno v:
JHEP Reports, Vol 3, Iss 2, Pp 100217- (2021)
Background & Aims: Increasing evidence highlights dietary fructose as a major driver of non-alcoholic fatty liver disease (NAFLD) pathogenesis, the majority of which is cleared on first pass through the hepatic circulation by enzymatic phosphorylatio
Externí odkaz:
https://doaj.org/article/4340ddc01197436fbd613f61ff255144
Autor:
Kensuke Shima, Inga Kaufhold, Thomas Eder, Nadja Käding, Nis Schmidt, Iretiolu M. Ogunsulire, René Deenen, Karl Köhrer, Dirk Friedrich, Sophie E. Isay, Florian Grebien, Matthias Klinger, Barbara C. Richer, Ulrich L. Günther, George S. Deepe, Thomas Rattei, Jan Rupp
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
ABSTRACT Infection with the obligate intracellular bacterium Chlamydia trachomatis is the most common bacterial sexually transmitted disease worldwide. Since no vaccine is available to date, antimicrobial therapy is the only alternative in C. trachom
Externí odkaz:
https://doaj.org/article/1f21d46625f04f0eb17183c2f20ab571
Autor:
Inês Baptista, Effrosyni Karakitsou, Jean-Baptiste Cazier, Ulrich L. Günther, Silvia Marin, Marta Cascante
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3574 (2022)
Increased expression of transketolase (TKT) and its isoform transketolase-like-1 (TKTL1) has been related to the malignant leukemia phenotype through promoting an increase in the non-oxidative branch of the pentose phosphate pathway (PPP). Recently,
Externí odkaz:
https://doaj.org/article/fe972233e6854472884ec1c6330b8b15