TNF-overexpression in Borna disease virus-infected mouse brains triggers inflammatory reaction and epileptic seizures.

Autor: Katharina Kramer, Dirk Schaudien, Ulrich L M Eisel, Sibylle Herzog, Jürgen A Richt, Wolfgang Baumgärtner, Christiane Herden

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e41476 (2012)

Proinflammatory state of the brain increases the risk for seizure development. Neonatal Borna disease virus (BDV)-infection of mice with neuronal overexpression of tumor necrosis factor-α (TNF) was used to investigate the complex relationship betwee

Externí odkaz: https://doaj.org/article/5e4b2970cec4477c9b1df20ee2be5a32

Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS

Autor: Valentina Pegoretti, Jan Bauer, Roman Fischer, Iskra Paro, Wanda Douwenga, Roland E. Kontermann, Klaus Pfizenmaier, Evelien Houben, Bieke Broux, Niels Hellings, Wia Baron, Jon D. Laman, Ulrich L. M. Eisel

Publikováno v: Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-13 (2023)

Abstract TNF signaling is an essential regulator of cellular homeostasis. Through its two receptors TNFR1 and TNFR2, soluble versus membrane-bound TNF enable cell death or survival in a variety of cell types. TNF-TNFRs signaling orchestrates importan

Externí odkaz: https://doaj.org/article/5841bf7052c54683ab34c56469546a89

Influencing cognitive performance via social interactions

Autor: Suzanne D. Lanooij, Ulrich L. M. Eisel, Wilhelmus H. I. M. Drinkenburg, Eddy A. van der Zee, Martien J. H. Kas

Publikováno v: Molecular Psychiatry. :28-33

Many psychiatric and neurological disorders present deficits in both the social and cognitive domain. In this perspectives article, we provide an overview and the potential of the existence of an extensive neurobiological substrate underlying the clo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbd70828834db987b19498406b125a5
https://hdl.handle.net/11370/8adb5f23-2a88-4623-be1c-7c8e7e8a2b68

Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases

Autor: Leonie Gouweleeuw, Petrus J.W. Naudé, Ulrich L. M. Eisel, Peter Paul De Deyn, Doortje W Dekens, Regien G. Schoemaker

Publikováno v: Ageing research reviews

Chronic (neuro)inflammation plays an important role in many age-related central nervous system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular dementia. Inflammation also characterizes many conditions that form a risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad8f2b7f77c752b71590f5d0da46471
https://doi.org/10.1016/j.arr.2021.101414

The continued need for animals to advance brain research

Autor: Paul J. Lucassen, Kate Jeffrey, Antonis Asiminas, Heidi M. B. Lesscher, Jos Prickaerts, Gertjan van Dijk, Amanda J. Kiliaan, Daniela Jezova, Carlos P. Fitzsimons, Klaus-Peter Lesch, S. Mechiel Korte, Ulrich L. M. Eisel, Roger A.H. Adan, Tamas Kozicz, Liset Menendez de la Prida, Joanes Grandjean, Marloes J. A. G. Henckens, Corette J. Wierenga, Vladyslav V. Vyazovskiy, Cyriel M. A. Pennartz, Marten P. Smidt, Ype Elgersma, Anne S. Mallien, Sharon M. Kolk, Liya Ma, Kirk Leech, Ingo Willuhn, Jorge F. Mejias, Maximilian Wiesmann, Frank J. Meye, Louk J. M. J. Vanderschuren, Marilise Escobar Burger, Sidarta Ribeiro, August B. Smit, Peter Meerlo, Robbert Havekes, Eddy A. van der Zee, Rixt van der Veen, Regien G. Schoemaker, Massimo Pasqualetti, Andries Kalsbeek, Martien J H Kas, Michael Bader, Joram D. Mul, Bernhard Englitz, Janine I. Rossato, Denovan P. Begg, Tomonori Takeuchi, Markus Wöhr, Antonio Fernández-Ruiz, Bella Williams, Nael Nadif Kasri, Aniko Korosi, Judith R. Homberg, Tom Beckers, Maarten Kamermans, Piotr Popik, Peter Gass, Umberto Olcese, Anna S. Mitchell, Christiane Herden, Jocelien D A Olivier, Monique Wolvekamp, Arjan Blokland, Azahara Oliva González, Natalia Alenina, Lisa Genzel, Wendy Jarrett, Ali-Akbar Salari, Roelof A. Hut, Anne-Marie van Dam, Anita Lüthi, Benno Roozendaal, Steven A. Kushner

Publikováno v: Neuron, 109(15), 2374-2379. Cell Press
Neuron, 109(15), 2374. Cell Press
Neuron, 109, 15, pp. 2374-2379
Neuron, 109, 2374-2379
Homberg, J R, Adan, R A H, Alenina, N, Asiminas, A, Bader, M, Beckers, T, Begg, D P, Blokland, A, Burger, M E, van Dijk, G, Eisel, U L M, Elgersma, Y, Englitz, B, Fernandez-Ruiz, A, Fitzsimons, C P, van Dam, A M, Gass, P, Grandjean, J, Havekes, R, Henckens, M J A G, Herden, C, Hut, R A, Jarrett, W, Jeffrey, K, Jezova, D, Kalsbeek, A, Kamermans, M, Kas, M J, Kasri, N N, Kiliaan, A J, Kolk, S M, Korosi, A, Korte, S M, Kozicz, T, Kushner, S A, Leech, K, Lesch, K P, Lesscher, H, Lucassen, P J, Luthi, A, Ma, L, Mallien, A S, Meerlo, P, Mejias, J F, Meye, F J, Mitchell, A S, Mul, J D, Olcese, U, González, A O, Olivier, J D A, Pasqualetti, M, Pennartz, C M A, Popik, P, Prickaerts, J, de la Prida, L M, Ribeiro, S, Roozendaal, B, Rossato, J I, Salari, A A, Schoemaker, R G, Smit, A B, Vanderschuren, L J M J, Takeuchi, T, van der Veen, R, Smidt, M P, Vyazovskiy, V V, Wiesmann, M, Wierenga, C J, Williams, B, Willuhn, I, Wöhr, M, Wolvekamp, M, van der Zee, E A & Genzel, L 2021, ' The continued need for animals to advance brain research ', Neuron, vol. 109, no. 15, pp. 2374-2379 . https://doi.org/10.1016/j.neuron.2021.07.015
Homberg, J R, Adan, R A H, Alenina, N, Asiminas, A, Bader, M, Beckers, T, Begg, D P, Blokland, A, Burger, M E, van Dijk, G, Eisel, U L M, Elgersma, Y, Englitz, B, Fernandez-Ruiz, A, Fitzsimons, C P, van Dam, A-M, Gass, P, Grandjean, J, Havekes, R, Henckens, M J A G, Herden, C, Hut, R A, Jarrett, W, Jeffrey, K, Jezova, D, Kalsbeek, A, Kamermans, M, Kas, M J, Kasri, N N, Kiliaan, A J, Kolk, S M, Korosi, A, Korte, S M, Kozicz, T, Kushner, S A, Leech, K, Lesch, K-P, Lesscher, H, Lucassen, P J, Luthi, A, Ma, L, Mallien, A S, Meerlo, P, Mejias, J F, Meye, F J, Mitchell, A S, Mul, J D, Olcese, U, González, A O, Olivier, J D A, Pasqualetti, M, Pennartz, C M A, Popik, P, Prickaerts, J, de la Prida, L M, Ribeiro, S, Roozendaal, B, Rossato, J I, Salari, A-A, Schoemaker, R G, Smit, A B, Vanderschuren, L J M J, Takeuchi, T, van der Veen, R, Smidt, M P, Vyazovskiy, V V, Wiesmann, M, Wierenga, C J, Williams, B, Willuhn, I, Wöhr, M, Wolvekamp, M, van der Zee, E A & Genzel, L 2021, ' The continued need for animals to advance brain research ', Neuron, vol. 109, no. 15, pp. 2374-2379 . https://doi.org/10.1016/j.neuron.2021.07.015
Neuron, 109(15), 2374-2379. CELL PRESS
Digital.CSIC. Repositorio Institucional del CSIC
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Policymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience research, until viable and translational alternatives become available a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2bfd05a12c81a1cd11d8bb8178a0953
https://doi.org/10.1016/j.neuron.2021.07.015