Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Ulrich Kubitscheck"'
Autor:
Kyriaki Barmpa, Claudia Saraiva, Diego Lopez-Pigozzi, Gemma Gomez-Giro, Elisa Gabassi, Sarah Spitz, Konstanze Brandauer, Juan E. Rodriguez Gatica, Paul Antony, Graham Robertson, Rahman Sabahi-Kaviani, Alessandro Bellapianta, Florentia Papastefanaki, Regina Luttge, Ulrich Kubitscheck, Ahmad Salti, Peter Ertl, Mario Bortolozzi, Rebecca Matsas, Frank Edenhofer, Jens C. Schwamborn
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)
Abstract Parkinson’s disease, an aging-associated neurodegenerative disorder, is characterised by nigrostriatal pathway dysfunction caused by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. Human in v
Externí odkaz:
https://doaj.org/article/01a3e63dcff24b67a4571fd2ecb5411b
Publikováno v:
Nucleus, Vol 15, Iss 1 (2024)
The analysis of nucleocytoplasmic transport of proteins and messenger RNA has been the focus of advanced microscopic approaches. Recently, it has been possible to identify and visualize individual pre-ribosomal particles on their way through the nucl
Externí odkaz:
https://doaj.org/article/df98f1705bb843079cb90cd76a08ae7e
Autor:
Martin F. Peter, Jan A. Ruland, Yeojin Kim, Philipp Hendricks, Niels Schneberger, Jan Peter Siebrasse, Gavin H. Thomas, Ulrich Kubitscheck, Gregor Hagelueken
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The tripartite ATP-independent periplasmic (TRAP) transporters use an extra cytoplasmic substrate binding protein (SBP) to transport a wide variety of substrates in bacteria and archaea. The SBP can adopt an open- or closed state depending o
Externí odkaz:
https://doaj.org/article/b83022bdcbc940eaaa4826707fa4d729
Autor:
Javiera Arcos, Felipe Grunenwald, Denisse Sepulveda, Carolina Jerez, Valentina Urbina, Tomas Huerta, Paulina Troncoso-Escudero, Daniel Tirado, Angela Perez, Rodrigo Diaz-Espinoza, Esteban Nova, Ulrich Kubitscheck, Juan Eduardo Rodriguez-Gatica, Claudio Hetz, Jorge Toledo, Pablo Ahumada, Diego Rojas-Rivera, Elisa Martín-Montañez, María Garcia-Fernandez, René L. Vidal
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Parkinson’s disease (PD) is the second most common late-onset neurodegenerative disease and the predominant cause of movement problems. PD is characterized by motor control impairment by extensive loss of dopaminergic neurons in the substa
Externí odkaz:
https://doaj.org/article/aba55e77f23e47fea777fe13c893bc03
Autor:
Martin F. Peter, Jan A. Ruland, Peer Depping, Niels Schneberger, Emmanuele Severi, Jonas Moecking, Karl Gatterdam, Sarah Tindall, Alexandre Durand, Veronika Heinz, Jan Peter Siebrasse, Paul-Albert Koenig, Matthias Geyer, Christine Ziegler, Ulrich Kubitscheck, Gavin H. Thomas, Gregor Hagelueken
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Tripartite ATP-independent periplasmic (TRAP) transporters are widespread in bacteria and archaea. Here, the authors used cryo-EM and a range of biophysical techniques to study the structure of function of the sialic acid TRAP transporter HiSiaQM.
Externí odkaz:
https://doaj.org/article/77d7c0c6e18748a0b6f9d495c47f442b
Autor:
Jan Andreas Ruland, Annika Marie Krüger, Kerstin Dörner, Rohan Bhatia, Sabine Wirths, Daniel Poetes, Ulrike Kutay, Jan Peter Siebrasse, Ulrich Kubitscheck
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Ribosomal biogenesis is known to require nuclear to cytoplasmic export, but the precise kinetics remain unclear. Here, the authors use super-resolution confocal microscopy and single molecule tracking to visualize export of single pre-60S particles t
Externí odkaz:
https://doaj.org/article/ba2f6db173b94b63a9e30b213dd11cd1
Autor:
Fabian Grein, Anna Müller, Katharina M. Scherer, Xinliang Liu, Kevin C. Ludwig, Anna Klöckner, Manuel Strach, Hans-Georg Sahl, Ulrich Kubitscheck, Tanja Schneider
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The mechanism of action of daptomycin, a lipopeptidic antibiotic, is unclear. Here, the authors show that Ca2+-daptomycin simultaneously interacts with lipid-coupled precursors of the bacterial cell envelope and with the anionic phospholipid phosphat
Externí odkaz:
https://doaj.org/article/3f8afa07193d465fb47aa48692257131
Autor:
Jonas Doerr, Martin Karl Schwarz, Dirk Wiedermann, Anke Leinhaas, Alina Jakobs, Florian Schloen, Inna Schwarz, Michael Diedenhofen, Nils Christian Braun, Philipp Koch, Daniel A. Peterson, Ulrich Kubitscheck, Mathias Hoehn, Oliver Brüstle
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
Transplantation of cells into the central nervous system has developed into a major avenue for replacing neurons lost to neurodegenerative disease. Here the authors develop an approach combining viral-based transynaptic tracing labeling and whole bra
Externí odkaz:
https://doaj.org/article/2cbee1c0f4eb4c74965a509ea89d4813
Autor:
Jan Peter Siebrasse, Ivona Djuric, Ulf Schulze, Marc A. Schlüter, Hermann Pavenstädt, Thomas Weide, Ulrich Kubitscheck
Publikováno v:
Data in Brief, Vol 7, Iss , Pp 1665-1669 (2016)
Using a combined approach of pulse chase labeling and single-particle tracking of Crb3A or 3B loaded vesicles we collected trajectories of different vesicle population in living podocyte cells and evaluated statistically their different mobility patt
Externí odkaz:
https://doaj.org/article/caab36f3b3cd4320935f5889d9d6423d
Publikováno v:
Molecules, Vol 20, Iss 4, Pp 6941-6958 (2015)
NKCS is an improved mutant of the bioactive peptide NK-2, which shows strong activity against Escherichia coli and low toxicity towards human cells. The different activity demonstrates the relevance of the physico-chemical nature of the target membra
Externí odkaz:
https://doaj.org/article/dd63d2eed9124dcdb741bbf21525c7a0