Výsledky vyhledávání - "Ulrich Krawinkel"

Autoreactive human T cell lines recognizing ribosomal protein L7

Autor: Esther Witte, Ulrich Krawinkel, Michael Schlesier, Johannes Donauer, Hans-Hartmut Peter, Michael Wochner

Publikováno v: International Immunology. 11:125-132

Sera of patients suffering from systemic lupus erythematosus (SLE) frequently contain oligoclonal IgG autoantibodies with high affinity for the ribosomal protein L7 (rpL7). The humoral autoimmune response to rpL7 apparently is driven by antigen and T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638f8d2c457ae0969b2d71674919f043
https://doi.org/10.1093/intimm/11.2.125

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Specific Interactions of the Autoantigen L7 with Multi-zinc Finger Protein ZNF7 and Ribosomal Protein S7

Autor: Ulrich Krawinkel, Stephan Witte

Publikováno v: Journal of Biological Chemistry. 272:22243-22247

The eucaryotic protein L7, which associates with the large subunit of ribosomes, has been shown to be a major autoantigen in systemic autoimmune arthritis. The N terminus carries a sequence motif that is similar to the leucine zipper domain of eucary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403fd0435bd5002d215211f01f86c466
https://doi.org/10.1074/jbc.272.35.22243

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Constitutive Expression of Human Ribosomal Protein L7 Arrests the Cell Cycle in G1and Induces Apoptosis in Jurkat T-Lymphoma Cells

Autor: Ulrich Krawinkel, Frank Neumann

Publikováno v: Experimental Cell Research. 230:252-261

Protein L7 is involved in translational control in eucaryotic cells as indicated by its association with ribosomes, its capability to inhibit specifically the cell-free translation of distinct mRNAs, and its interference with the synthesis of two maj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c02193ecd35d0630ad87c5969712869
https://doi.org/10.1006/excr.1996.3417

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Mass Spectrometric Identification of Leucine Zipper-like Homodimer Complexes of the Autoantigen L7

Autor: Ulrich Krawinkel, Michael Przybylski, Stephan Witte, Frank Neumann

Publikováno v: Journal of Biological Chemistry. 271:18171-18175

The eucaryotic protein L7 has been shown to associate in the cytoplasm with the large subunit of ribosomes and to interact specifically with as yet unknown cognate sites of mRNA, thereby inhibiting cell-free translation (Neumann, F., Hemmerich, P., v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f9e52dd01c10e279f7e8a301d2da20
https://doi.org/10.1074/jbc.271.30.18171

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Human ribosomal protein L7 inhibits cell-free translation in reticulocyte lysates and affects the expression of nuclear proteins upon stable transfection into Jurkat T-lymphoma cells

Autor: Ulrich Krawinkel, Peter Hemmerich, Hans-Hartmut Peter, A H von Mikecz, Frank Neumann

Publikováno v: Nucleic Acids Research. 23:195-202

Eucaryotic ribosomal protein L7 carries a 'Basic-Region-Leucine-Zipper (BZIP)'-like region which mediates high-affinity binding to mRNA and 28S rRNA and formation of homodimers [P. Hemmerich et al. (1993) Nucleic Acids Res. 21, 223-231). Its biologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef23846a3d2b3136be53687d3d8524b8
https://doi.org/10.1093/nar/23.2.195

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Characterization of Eukaryotic Protein L7 as a Novel Autoantigen Which Frequently Elicits an Immune Response in Patients Suffering from Systemic Autoimmune Disease

Autor: Anna von Mikecz, Ulrich Krawinkel, Peter Hemmerich, Hans-Hartmut Peter

Publikováno v: Immunobiology. 192:137-154

Autoantibodies targeted against cellular proteins and nucleic acids are a common feature of autoimmune diseases. In this study, we show that ribosomal protein L7 is a novel autoantigen in patients suffering from systemic lupus erythematosus (SLE) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0deff43ee9576cdc33c83abfe0b24d
https://doi.org/10.1016/s0171-2985(11)80413-4

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Biased T cell receptor Vα region repertoire in the synovial fluid of rheumatoid arthritis patients

Autor: Heiko Taube, Ulrich Krawinkel, Susanne Kroninger, Gesa Ricken, Inga Melchers, Gerd Pluschke, Hans-Hartmut Peter, Klaus Eichmann

Publikováno v: European Journal of Immunology. 21:2749-2754

Synovial T lymphocytes seem to contribute to the pathogenesis of rheumatoid arthritis (RA). Since very little is known about the structural heterogeneity of their T cell antigen receptors (TcR), we analyzed TcR alpha chain mRNA of synovial fluid T ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317cfaaa645fe9ae8e81b820275b3128
https://doi.org/10.1002/eji.1830211115

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Novel Autoantibodies in Human Diseases

Autor: Röther E, Frank Neumann, Hans-Hartmut Peter, M. Schlesier, A H von Mikecz, Peter Hemmerich, Ulrich Krawinkel, I. Melchers, D. Metzger, A. Rump

Publikováno v: Journal of Interferon Research. 14:153-155

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453401476f2010ec458405cac60ad743
https://doi.org/10.1089/jir.1994.14.153

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Matrix metalloproteinase-19 in capillary endothelial cells: expression in acutely, but not in chronically, inflamed synovium

Autor: Ulrich Krawinkel, Radislav Sedlacek, Cornelia Kolb, Simon Mauch

Publikováno v: Experimental cell research. 250(1)

Matrix metalloproteinase-19 (MMP-19), originally isolated as an autoantigen from the synovium of a patient suffering from rheumatoid arthritis (RA), is expressed in smooth muscle cells of the tunica media of large blood vessels of an RA patient, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44464ccc5ccb22306201c2afacae2cc2
https://pubmed.ncbi.nlm.nih.gov/10388526

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