Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ulrich Jahnel"'
Autor:
Thomas M. Tzschentke, Michael Gautrois, Wolfgang P. Schröder, Stefan Schunk, Werner Englberger, Horst Beier, Thomas Christoph, Klaus Schiene, Jean De Vry, Thomas Koch, Babette Kögel, Ulrich Jahnel, Klaus Linz, Stefanie Frosch
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 349:535-548
Cebranopadol (trans-6'-fluoro-4',9'-dihydro-N,N-dimethyl-4-phenyl-spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-amine) is a novel analgesic nociceptin/orphanin FQ peptide (NOP) and opioid receptor agonist [Ki (nM)/EC50 (nM)/relative efficacy (%):
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0031d5a8a624f155ce9156d82b5170d
https://doi.org/10.1124/jpet.114.213694
https://doi.org/10.1124/jpet.114.213694
Autor:
Mark Ballantyne, Corinne van Dorp, Ulrich Jahnel, Olaf Will, David Kirkland, Alexander Kraus, Stefanie Harlfinger
Publikováno v:
Regulatory Toxicology and Pharmacology. 62:151-159
The metabolite of several amide anaesthetics, 2,6-xylidine, is a possible human (Group 2B) carcinogen and induced nasal tumours in rats after dietary administration. However, published papers on the genotoxicity of 2,6-xylidine in vitro have given in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8676f57c5fb4763fa9e523233256b9d1
https://doi.org/10.1016/j.yrtph.2011.08.010
https://doi.org/10.1016/j.yrtph.2011.08.010
Publikováno v:
European Journal of Pain. 14:814-821
The novel analgesic tapentadol combines μ-opioid receptor agonism and noradrenaline reuptake inhibition in a single molecule and shows potent analgesia in various rodent models of pain. We analyzed the contribution of opioid and monoaminergic mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af35e22a84c4f2dd1a8651481263b5c
https://doi.org/10.1016/j.ejpain.2010.05.005
https://doi.org/10.1016/j.ejpain.2010.05.005
Publikováno v:
Naunyn-Schmiedeberg’s Archives of Pharmacology. 349:408-415
Both in rat left atrial heart and in aortic smooth muscle preparations, phenylephrine (PE) caused a concentration-dependent increase in force of contraction (FC) in the presence of atenolol (10 mumol/l), which was antagonized by phentolamine, prazosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57bc09745fd3478902025aebf3ee6f6
https://doi.org/10.1007/bf00170888
https://doi.org/10.1007/bf00170888
Publikováno v:
Drug Development Research.
Tapentadol is a novel analgesic with m-opioid receptor agonistic and norepinephrine reuptake inhibiting activities at submicromolar concentrations. Given that inhibition of cardiac potassium currents by noncardiovascular pharmaceuticals is a critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a8a9923013c2004849f7835f4f1628e
https://doi.org/10.1002/ddr.20360
https://doi.org/10.1002/ddr.20360
Autor:
Babette-Yvonne Koegel, Jens-Ulrich Stegmann, Thomas M. Tzschentke, Werner Englberger, Regina Kleinert, Ulrich Jahnel, Horst Weber, Thomas Christoph, Akiko Okamoto, Claudia Lange, Klaus Schiene, David Upmalis, Jean De Vry
Publikováno v:
Drugs of today (Barcelona, Spain : 1998). 45(7)
Tapentadol exerts its analgesic effects through micro opioid receptor agonism and noradrenaline reuptake inhibition in the central nervous system. Preclinical studies demonstrated that tapentadol is effective in a broad range of pain models, includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6dc824164c1cb176baba821eac3187
https://pubmed.ncbi.nlm.nih.gov/19834626
https://pubmed.ncbi.nlm.nih.gov/19834626
Publikováno v:
The Journal of Physiology. 432:621-637
1. The effects of alpha 1-adrenoceptor stimulation on transmembrane potential, currents and ion fluxes were investigated in multicellular preparations and/or single cells obtained from the left atrium of rat hearts. 2. In multicellular preparations,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f7180aedf4fabe33e75cfb58b087b8
https://doi.org/10.1113/jphysiol.1991.sp018404
https://doi.org/10.1113/jphysiol.1991.sp018404
Autor:
Klaus Schiene, Ulrich Jahnel, Thomas M. Tzschentke, Michael Haurand, Hagen-Heinrich Hennies, Elmar Friderichs, Thomas I. F. H. Cremers, Jean De Vry, Werner Englberger, Babette-Yvonne Koegel, Thomas Christoph
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 323(1)
(–)-(1 R ,2 R )-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol HCl) is a novel μ-opioid receptor (MOR) agonist ( K i = 0.1 μM; relative efficacy compared with morphine 88% in a [ 35 S]guanosine 5′-3- O -(thio)triph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7e3fb6f7a808bc5b3c2163c97c38e9
https://pubmed.ncbi.nlm.nih.gov/17656655
https://pubmed.ncbi.nlm.nih.gov/17656655
Autor:
Ulrich Jahnel, Clemens Gillen
Publikováno v:
Analgesics: From Chemistry and Pharmacology to Clinical Application
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::326d6553ee20c2ee4de54a6ffc71e070
https://doi.org/10.1002/3527605614.ch17
https://doi.org/10.1002/3527605614.ch17
Publikováno v:
European journal of pharmacology. 512(1)
The effects of drugs that inhibit human ether-a-go-go-related gene (HERG) related cardiac potassium channels on the variability of QT duration as a sign of repolarisation instability were evaluated in conscious telemetered dogs. QT duration variabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5845ed0d3d74a3b6ac4ba9e702aa5b
https://pubmed.ncbi.nlm.nih.gov/15814090
https://pubmed.ncbi.nlm.nih.gov/15814090