Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ulrich Hubscher"'
Publikováno v:
The Scientific World Journal, Vol 2, Pp 275-281 (2002)
Proofreading function by the 3′→ 5′ exonuclease of DNA polymerase δ (pol δ) is consistent with the observation that deficiency of the associated exonuclease can lead to a strong mutation phenotype, high error rates during DNA replication, and
Externí odkaz:
https://doaj.org/article/eef236012efb4fb4980ec867e2e9e5c6
Autor:
Giuseppe Villani, Igor Shevelev, Eleonora Orlando, Helmut Pospiech, Juhani E Syvaoja, Enni Markkanen, Ulrich Hubscher, Nicolas Tanguy Le Gac
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93908 (2014)
DNA polymerase ε (pol ε) is believed to be the leading strand replicase in eukaryotes whereas pols λ and β are thought to be mainly involved in re-synthesis steps of DNA repair. DNA elongation by the human pol ε is halted by an abasic site (apur
Externí odkaz:
https://doaj.org/article/7b559f9d552e47b6b5eda7eab0621523
Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in
Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in
Autor:
Giuseppe, Villani, Ulrich, Hubscher, Nadege, Gironis, Sinikka, Parkkinen, Helmut, Pospiech, Igor, Shevelev, Giulia, di Cicco, Enni, Markkanen, Juhani E, Syväoja, Nicolas, Tanguy Le Gac
Publikováno v:
The Journal of biological chemistry
DNA polymerase (pol) ϵ is thought to be the leading strand replicase in eukaryotes, whereas pols λ and β are believed to be mainly involved in re-synthesis steps of DNA repair. DNA elongation by the human pol ϵ is halted by an abasic site (apurin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8340100fd022a8ed152f1b7eb8521ef5
Publikováno v:
The Journal of biological chemistry
(1999).
info:cnr-pdr/source/autori:Barbara Pascucci, Manuel Stucki, Zophonìas Jònsson, Eugenia Dogliotti and Ulrich Hubscher/titolo:Long patch base excision repair with purified human proteins: DNA ligase I as patch size mediator for DNA polymerase ? and ?/doi:/rivista:The Journal of biological chemistry (Print)/anno:1999/pagina_da:/pagina_a:/intervallo_pagine:/volume
(1999).
info:cnr-pdr/source/autori:Barbara Pascucci, Manuel Stucki, Zophonìas Jònsson, Eugenia Dogliotti and Ulrich Hubscher/titolo:Long patch base excision repair with purified human proteins: DNA ligase I as patch size mediator for DNA polymerase ? and ?/doi:/rivista:The Journal of biological chemistry (Print)/anno:1999/pagina_da:/pagina_a:/intervallo_pagine:/volume
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=cnr_________::245ca12bbe64c3a44fb63b6fed655465
https://publications.cnr.it/doc/209946
https://publications.cnr.it/doc/209946
Publikováno v:
Critical Reviews in Biochemistry and Molecular Biology. 43:285-285
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9785842f7ede444be0f0e51f6a15d6e4
https://doi.org/10.1080/10409230802307248
https://doi.org/10.1080/10409230802307248
Autor:
Giada A. Locatelli, Nicolas Tanguy Le Gac, Barbara van Loon, Ulrich Hubscher, Sinikka Parkkinen, Juhani E. Syväoja, Giuseppe Villani
Publikováno v:
Biochemical Journal; Jul2010, Vol. 429 Issue 3, p573-582, 10p
Autor:
Elisa Mentegari, Federica Bertoletti, Miroslava Kissova, Elisa Zucca, Silvia Galli, Giulia Tagliavini, Anna Garbelli, Antonio Maffia, Silvia Bione, Elena Ferrari, Fabrizio d’Adda di Fagagna, Sofia Francia, Simone Sabbioneda, Liuh-Yow Chen, Joachim Lingner, Valerie Bergoglio, Jean-Sébastien Hoffmann, Ulrich Hübscher, Emmanuele Crespan, Giovanni Maga
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2365 (2021)
Telomerase negative cancer cell types use the Alternative Lengthening of Telomeres (ALT) pathway to elongate telomeres ends. Here, we show that silencing human DNA polymerase (Pol λ) in ALT cells represses ALT activity and induces telomeric stress.
Externí odkaz:
https://doaj.org/article/f2080c2f615b4c52a3b41333f1fea6ec
Autor:
Emmanuele Crespan, Antonia Furrer, Marcel Rösinger, Federica Bertoletti, Elisa Mentegari, Giulia Chiapparini, Ralph Imhof, Nathalie Ziegler, Shana J. Sturla, Ulrich Hübscher, Barbara van Loon, Giovanni Maga
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Oxidative stress is a common source of DNA damage and is repaired by the base excision repair machinery, including polymerase beta. Here the authors find that polymerase beta, and to a lesser extent lambda, can mistakenly incorporate ribonucleotides
Externí odkaz:
https://doaj.org/article/763387984e1f4e0ab862ad33d073b020