Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Ulrich Hoffmüller"'
1
In Vitro Evolution and Selection of Proteins: Ribosome Display for Larger Libraries
Autor: Ulrich Hoffmüller, Jens Schneider-Mergener
Publikováno v: Angewandte Chemie (International ed. in English). 37(23)
The cell-free production of large protein libraries can now be achieved with the ribosome display technique. The use of intact ribosomes (R) in the translation of a mRNA library enables the rapid selection of the generated proteins (P) according to t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76528e30c9b762a10a59a66028c87097
https://pubmed.ncbi.nlm.nih.gov/29711419
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3
Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes
Autor: Maigan A. Hulme, Stephanie McClymont, Jeffrey A. Bluestone, Weihong Liu, Amy L. Putnam, Jonathan H. Esensten, Udo Baron, Sven Olek, Ulrich Hoffmüller, Todd M. Brusko, Michael R. Lee
Publikováno v: The Journal of Immunology. 186:3918-3926
Regulatory T cells (Tregs) constitute an attractive therapeutic target given their essential role in controlling autoimmunity. However, recent animal studies provide evidence for functional heterogeneity and lineage plasticity within the Treg compart
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa15ed234403bbf4c0105516bd46f47f
https://doi.org/10.4049/jimmunol.1003099
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5
Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope
Autor: Thomas Ast, José R. Pires, Ulrich Hoffmüller, Hartmut Oschkinat, Fatemeh Taha-Nejad, Jens Schneider-Mergener, Ronald Kühne, Maria J. Macias, F. Toepert
Publikováno v: Journal of Molecular Biology. 314:1147-1156
The single mutation L30 K in the Hu-Yap65 WW domain increased the stability of the complex with the peptide GTPPPPYTVG (K(d)=40(+/-5) microM). Here we report the refined solution structure of this complex by NMR spectroscopy and further derived struc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be71ba4979002372f0f30db74c3ed52b
https://doi.org/10.1006/jmbi.2000.5199
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6
Spot synthesis: observations and optimizations
Autor: Rudolf Volkmer-Engert, Achim Kramer, Liying Dong, Ulrich Hoffmüller, D. Winkler, Ulrich Reineke, Jens Schneider-Mergener, Berit Hoffmann
Publikováno v: The Journal of Peptide Research. 54:319-326
Positionally addressable syntheses of peptides on continuous cellulose membranes (spot synthesis) have often been reported in detail, but important questions dealing with synthesis quality, reproducibility and subsequent binding assays have largely b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41f9e34cc6b1d82eda8ca24ed0432fd5
https://doi.org/10.1034/j.1399-3011.1999.00108.x
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7
Interaktion einer PDZ-Proteindomäne mit einer synthetischen Bibliothek aller C-Termini humaner Proteine
Autor: Jennifer Ashurst, Frank Kleinjung, Rudolf Volkmer-Engert, Doris Koesling, Jens Schneider-Mergener, Michael Russwurm, Ulrich Hoffmüller, Hartmut Oschkinat
Publikováno v: Angewandte Chemie. 111:2180-2184
Neue Wechselwirkungspartner einer PDZ-Proteindomane konnten anhand einer Bibliothek identifiziert werden, die aus allen bekannten C-terminalen Peptiden („P” in der schematischen Darstellung) humaner Proteine besteht. Die Bibliothek bestand aus or
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05e72430a9191abc9a14c90806e4f195
https://doi.org/10.1002/(sici)1521-3757(19990712)111:13/14<2180::aid-ange2180>3.0.co
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9
Epigenetic quantification of tumor-infiltrating T-lymphocytes
Autor: Sven Olek, Udo Baron, Ivana Türbachova, Jörn Gröne, Tatjana I. Cornu, Philipp Lohneis, Tim Schwachula, Thorsten Dickhaus, Ulrich Hoffmüller, Christoph Loddenkemper, Andreas Grützkau, Alexander Mustea, Martin Kruschewski, Jalid Sehouli
The immune system plays a pivotal role in tumor establishment. However, the role of T-lymphocytes within the tumor microenvironment as major cellular component of the adaptive effector immune response and their counterpart, regulatory T cells (Treg),
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d19fb1fe1bd90ea28d3a90cf09adec
https://europepmc.org/articles/PMC3278789/
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10
DNA methylation analysis as a tool for cell typing
Autor: Florian Eckhardt, Ivana Türbachova, Paul Gardina, Alexander Hellwag, Sven Olek, Ulrich Hoffmüller, Kurt Berlin, Udo Baron
Publikováno v: Epigenetics. 1(1)
Cell therapeutic approaches currently lack definitive quality control measures which guarantee safety in clinical applications and create consistent standards for regulatory approval. These approaches rely on isolation, purification and possibly ex v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2bc4bac814be6da4ef3d37227347bf0
https://pubmed.ncbi.nlm.nih.gov/17998806
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