Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Ulrich Hengst"'
Autor:
Lisa K. Randolph, Michaela M. Pauers, José C. Martínez, Leslie J. Sibener, Michael A. Zrzavy, Nyle A. Sharif, Tatiana M. Gonzalez, Kapil V. Ramachandran, Daniel Dominguez, Ulrich Hengst
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114747- (2024)
Summary: The formation, stabilization, and elimination of synapses are tightly regulated during neural development and into adulthood. Pumilio RNA-binding proteins regulate the translation and localization of many synaptic mRNAs and are developmental
Externí odkaz:
https://doaj.org/article/8f996393a99b4a039d1d35ce57eed479
Autor:
Sebastien M. Weyn-Vanhentenryck, Huijuan Feng, Dmytro Ustianenko, Rachel Duffié, Qinghong Yan, Martin Jacko, Jose C. Martinez, Marianne Goodwin, Xuegong Zhang, Ulrich Hengst, Stavros Lomvardas, Maurice S. Swanson, Chaolin Zhang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The precise timing of neurodevelopmental splicing switches and the underlying regulatory mechanisms remain poorly understood. This study identifies two major waves of developmental switches under the control of distinct combinations of RNA-binding pr
Externí odkaz:
https://doaj.org/article/e95f34f767ed420686c114eb449248ee
Publikováno v:
Cell Reports, Vol 20, Iss 13, Pp 3085-3098 (2017)
Localized protein synthesis is a mechanism for developing axons to react acutely and in a spatially restricted manner to extracellular signals. As such, it is important for many aspects of axonal development, but its role in the formation of presynap
Externí odkaz:
https://doaj.org/article/0de88b19892e487285b8665dcb4f9436
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
The molecular mechanisms underlying retrograde transport in axons are only partially understood. Villarinet al. show that in cultured DRG neurons, extracellular trophic cues such as NGF dynamically regulate local protein synthesis of dynein cofactors
Externí odkaz:
https://doaj.org/article/cc2cfa3b845c4a8abe1fd6878230bc89
Publikováno v:
Cell Reports, Vol 29, Iss 2, Pp 363-377.e5 (2019)
Summary: Axon growth is regulated externally by attractive and repulsive cues generated in the environment. In addition, intrinsic pathways govern axon development, although the extent to which axons themselves can influence their own growth is unkno
Externí odkaz:
https://doaj.org/article/a0013500de88495699c80bc06f30babb
Autor:
Cláudio Gouveia Roque, Kyung Min Chung, Ethan P. McCurdy, Radhika Jagannathan, Lisa K. Randolph, Krystal Herline-Killian, Jimena Baleriola, Ulrich Hengst
Publikováno v:
Science Advances. 9
Gene expression is changed by disease, but how these molecular responses arise and contribute to pathophysiology remains less understood. We discover that β-amyloid, a trigger of Alzheimer’s disease (AD), promotes the formation of pathological CRE
Autor:
Kyung Min Chung, Hyunha Kim, Cláudio Gouveia Roque, Ethan P. McCurdy, Trang T.T. Nguyen, Markus D. Siegelin, Jee-Yeon Hwang, Ulrich Hengst
Publikováno v:
Cell reports. 41(3)
Cells possess several conserved adaptive mechanisms to respond to stress. Stress signaling is initiated to reestablish cellular homeostasis, but its effects on the tissue or systemic levels are far less understood. We report that the secreted luminal
Publikováno v:
Cell Reports, Vol 29, Iss 2, Pp 363-377.e5 (2019)
Summary: Axon growth is regulated externally by attractive and repulsive cues generated in the environment. In addition, intrinsic pathways govern axon development, although the extent to which axons themselves can influence their own growth is unkno
Publikováno v:
Alzheimer's & Dementia. 16
Publikováno v:
Methods Mol Biol
Methods in Molecular Biology ISBN: 9781493994915
Methods in Molecular Biology ISBN: 9781493994915
Live imaging of microfluidically isolated axons permits study of the dynamic behavior of fluorescently tagged proteins and vesicles in these neuronal processes. We use this technique to study the motility and transport of ESCRT proteins in axons of p