Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Ulrich Heiser"'
Autor:
Hans-Ulrich Demuth, Torsten Hoffmann, Stephan Schilling, Ulrich Heiser, Livia Böhme, Martin Kleinschmidt, Antje Meyer, Martina Farcher, Karl-Ulrich Bühring, Stephan Kurat, Birgit Hutter-Paier, Inge Lues
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 362(1)
Numerous studies suggest that the majority of amyloid-β (Aβ) peptides deposited in Alzheimer's disease (AD) are truncated and post-translationally modified at the N terminus. Among these modified species, pyroglutamyl-Aβ (pE-Aβ, including N3pE-A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8092972b5b6bfac758b336b735d6e0
https://pubmed.ncbi.nlm.nih.gov/28446518
https://pubmed.ncbi.nlm.nih.gov/28446518
Autor:
Stephan Schilling, Piotr Mydel, Roland Jonsson, Katarzyna Maresz, Sigrid Graubner, Hans-Ulrich Demuth, Holger Cynis, Annelie Hellvard, Jan Potempa, Ulrich Heiser
Publikováno v:
Journal of Infectious Diseases; Vol 207
Journal of Infectious Diseases
Journal of Infectious Diseases
Background. Septic arthritis is a severe and rapidly debilitating disease mainly caused by Staphylococcus aureus. Here, we assess the antiarthritic efficiency of glutaminyl cyclase (QC) inhibitors. Methods. Mice were inoculated with an arthritogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81eb3ed1929f845d9e54072ea1c3e758
Autor:
Astrid Kehlen, Hans-Ulrich Demuth, Joanna Koziel, Piotr Mydel, Jan Potempa, Lutz Zeitlmann, Annelie Hellvard, Ulrich Heiser, Nicolas Delaleu, André J. Niestroj
Publikováno v:
Scientific Reports
Rheumatoid arthritis is characterised by synovial inflammation and proliferation of fibroblast-like synoviocytes. The induction of apoptosis has long been proposed as a target for proliferative autoimmune diseases and has further been shown to act as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea758e8a09490eb5f2829800a38b401
http://europepmc.org/articles/PMC4980610
http://europepmc.org/articles/PMC4980610
Autor:
Stephan von Hörsten, Hans-Ulrich Demuth, Raik Wolf, Torsten Hoffmann, Harald Stiller, Ulrich Heiser, Florian Kaestner, Matthias Rothermundt, Susanne Manhart, Jens-Ulrich Rahfeld, Leona Wagner
Background Dipeptidyl peptidase 4 (DPP4; EC 3.4.14.5; CD26) is a membrane-bound or shedded serine protease that hydrolyzes dipeptides from the N-terminus of peptides with either proline or alanine at the penultimate position. Substrates of DPP4 inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2faecc089c0a52d5889d491835517b49
https://publica.fraunhofer.de/handle/publica/246876
https://publica.fraunhofer.de/handle/publica/246876
Autor:
Mirko Buchholz, Hans-Ulrich Demuth, Stephan Schilling, Birgit Koch, Michael Wermann, Ulrich Heiser
Publikováno v:
Chemical Biology & Drug Design. 80:937-946
Glutaminyl cyclases (QCs) catalyze the formation of pyroglutamate-modified amyloid peptides deposited in neurodegenerative disorders such as Alzheimer’s disease. Inhibitors of QC are currently in development as potential therapeutics. The crystal s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::befa01d8e61f8a7a3b1ee0e75a61747d
https://doi.org/10.1111/cbdd.12046
https://doi.org/10.1111/cbdd.12046
Autor:
Milton T. Stubbs, Christoph Parthier, Birgit Koch, Stephan Schilling, David Ruiz-Carrillo, Mirko Buchholz, Jens-Ulrich Rahfeld, Hans-Henning Ludwig, Michael Wermann, Hans-Ulrich Demuth, Tresfore Dambe, Ulrich Heiser
Publikováno v:
Biochemistry. 50:6280-6288
Formation of N-terminal pyroglutamate (pGlu or pE) from glutaminyl or glutamyl precursors is catalyzed by glutaminyl cyclases (QC). As the formation of pGlu-amyloid has been linked with Alzheimer's disease, inhibitors of QCs are currently the subject
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0cdd61be71835aac71892d17a91bff
https://doi.org/10.1021/bi200249h
https://doi.org/10.1021/bi200249h
Autor:
Mirko Buchholz, Antje Hamann, Stephan Schilling, Livia Böhme, Torsten Hoffmann, Ulrich Heiser, Wolfgang Brandt, Susanne Aust, Hans-Ulrich Demuth
Publikováno v:
Journal of Medicinal Chemistry. 52:7069-7080
The inhibition of human glutaminyl cyclase (hQC) has come into focus as a new potential approach for the treatment of Alzheimer's disease. The hallmark of this principle is the prevention of the formation of Abeta(3,11(pE)-40,42), as these Abeta-spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8088dcc160dc2e4ca8294269ae8493d2
https://doi.org/10.1021/jm900969p
https://doi.org/10.1021/jm900969p
Autor:
Ulf-Torsten Gärtner, Kiyoshi Ito, Yoshitaka Nakajima, Yue Xu, Torsten Hoffmann, Hiroshi Oyama, Tadashi Yoshimoto, Heng Zheng, Hans-Ulrich Demuth, Ulrich Heiser
Publikováno v:
Journal of Molecular Biology. 375:708-719
A new inhibitor, H-Ala-Ile-pyrrolidin-2-yl boronic acid, was developed as an inhibitor against prolyl tripeptidyl aminopeptidase with a K(i) value of 88.1 nM. The structure of the prolyl tripeptidyl aminopeptidase complexed with the inhibitor (enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527bade9e4dfd2dcfadb1cd558306089
https://doi.org/10.1016/j.jmb.2007.09.077
https://doi.org/10.1016/j.jmb.2007.09.077
Autor:
Stephan Schilling, Hans-Ulrich Demuth, Holger Cynis, Mandy Bodnár, Takaomi C. Saido, Ulrich Heiser, Torsten Hoffmann
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1764:1618-1625
Mammalian cell lines were examined concerning their Glutaminyl Cyclase (QC) activity using a HPLC method. The enzyme activity was suppressed by a QC specific inhibitor in all homogenates. Aim of the study was to prove whether inhibition of QC modifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507d46a3422dce6162b2c295bf5d5245
https://doi.org/10.1016/j.bbapap.2006.08.003
https://doi.org/10.1016/j.bbapap.2006.08.003
Autor:
Torsten Hoffmann, Jens Rüter, Petra C. Arck, Hans-Ulrich Demuth, M. Hildebrandt, Burghard F. Klapp, Ulrich Heiser
Publikováno v:
Cellular Immunology. 220:150-156
Inhibition of DPP IV has been shown to abrogate the stress-related increase in murine abortions and a concomitant increase in gamma-interferon. The aim of the present study was to investigate a potential impact of the DPP IV inhibitor Isoleucine Cyan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd182a444cb94b35c7514618f3094c3b
https://doi.org/10.1016/s0008-8749(03)00028-5
https://doi.org/10.1016/s0008-8749(03)00028-5