Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ulrich Haupts"'
Autor:
Anja Katzschmann, Ulrich Haupts, Anja Reimann, Florian Settele, Manja Gloser-Bräunig, Erik Fiedler, Christoph Parthier
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Affilin proteins, artificial binding proteins based on the ubiquitin scaffold, have been generated by directed protein evolution to yield de-novo variants that bind the extra-domain B (EDB) of oncofetal fibronectin, an established marker of
Externí odkaz:
https://doaj.org/article/34f0265bf9634fa7ad3a2bdef2603853
Autor:
Florian Job, Florian Settele, Susan Lorey, Chris Rundfeldt, Lars Baumann, Annette G. Beck-Sickinger, Ulrich Haupts, Hauke Lilie, Eva Bosse-Doenecke
Publikováno v:
FEBS Open Bio, Vol 5, Iss 1, Pp 579-593 (2015)
In the search for effective therapeutic strategies, protein‐based biologicals are under intense development. While monoclonal antibodies represent the majority of these drugs, other innovative approaches are exploring the use of scaffold proteins f
Externí odkaz:
https://doaj.org/article/e7f8eece52da409e85bd005ae63a9579
Autor:
Carl I Webster, Matthew Burrell, Lise-Lotte Olsson, Susan B Fowler, Sarah Digby, Alan Sandercock, Arjan Snijder, Jan Tebbe, Ulrich Haupts, Joanna Grudzinska, Lutz Jermutus, Christin Andersson
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104001 (2014)
Neprilysin is a transmembrane zinc metallopeptidase that degrades a wide range of peptide substrates. It has received attention as a potential therapy for Alzheimer's disease due to its ability to degrade the peptide amyloid beta. However, its broad
Externí odkaz:
https://doaj.org/article/d1ffb03507e3488eaa6fde76864289c9
Publikováno v:
Protein expression and purification. 149
Protein based binding molecules have a broad applicability from therapeutic to technical use. Monoclonal antibodies represent the major class of this type of agents complemented by innovative approaches using scaffold proteins with tailor-made proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8069ba394ce932387dffa1199fbaf248
https://pubmed.ncbi.nlm.nih.gov/29704557
https://pubmed.ncbi.nlm.nih.gov/29704557
Autor:
Matthew Sanders, Melissa Vandersluis, Ulrich Haupts, Renaud Jacquemart, Mochao Zhao, James G. Stout
Publikováno v:
Vaccine. 37(36)
Affinity chromatography is among the most powerful separation techniques, achieving the finest separation with high yields even in the most challenging feed streams. Incorporating affinity chromatography in vaccine purification has long been attempte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd11bb7ebb3a6d03a4e961f8d651177
https://pubmed.ncbi.nlm.nih.gov/29627235
https://pubmed.ncbi.nlm.nih.gov/29627235
Autor:
Christin Andersson, Per Ola Freskgård, Matthew Burrell, Lutz Jermutus, Carl I. Webster, Juliette Janson, Anna Bogstedt, Simon J. Henderson, Ulrich Haupts, Rajesh Narwal, Tom Goldschmidt, Ann-Charlott Steffen, Jan Tebbe, Susan B. Fowler, Paulina Appelkvist
Publikováno v:
Brain
Lowering levels of peripheral amyloid-β has been proposed as a strategy to reduce plaques in patients with Alzheimer’s disease. Henderson et al. test a modified version of the amyloid-degrading enzyme neprilysin in rats, monkeys and Tg2576 mice. L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94a9430aba27b96a125b51cbeba9616
http://europepmc.org/articles/PMC3914468
http://europepmc.org/articles/PMC3914468
Autor:
David Myszka, Uwe Gritzan, Andreas Scheidig, Peter Scholz, Hanna Plittersdorf, Michael Strerath, Christian Votsmeier, Ulrich Haupts, Oliver Hesse, Andrea Eicker, Klaus Pellengahr, Wayne Coco
Publikováno v:
mAbs. 4:341-348
In therapeutic or diagnostic antibody discovery, affinity maturation is frequently required to optimize binding properties. In some cases, achieving very high affinity is challenging using the display-based optimization technologies. Here we present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67b80a13f7edfeb7aaa1ca452fa183c
https://doi.org/10.4161/mabs.19981
https://doi.org/10.4161/mabs.19981
Publikováno v:
Protein Engineering Handbook, Volume 1 & Volume 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24a169d00a33d24aeb9a3b5891fb43b5
https://doi.org/10.1002/9783527634026.ch29
https://doi.org/10.1002/9783527634026.ch29
Autor:
Jörg Nerkamp, Christian M. Lange, Arnd Steuernagel, Ilka Hänssgen, Anja Kunert, Maren Meysing, Ulrike Fiedler, Chris Rundfeldt, Markus Fiedler, Eva Bosse-Doenecke, Una Rauchhaus, Thomas Göttler, Susan Lorey, Ulrich Haupts, Erik Fiedler, Manja Gloser
Publikováno v:
The Journal of Biological Chemistry
Background: Targeting molecules to tumor cells is a promising mode of action for cancer therapy. Results: Ubiquitin-based high affinity, specific, and stable binding molecules for extradomain B are accumulated in the tumor. Conclusion: Ubiquitin may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cee2b3b25ace920cfb063b6ef304588
https://pubmed.ncbi.nlm.nih.gov/24474690
https://pubmed.ncbi.nlm.nih.gov/24474690
Autor:
Andrew J. Pope, Sandra Turconi, Stephen Ashman, David L. Earnshaw, Ryan P. Bingham, Murray J. B. Brown, Ulrich Haupts, Kenneth Fantom, Kerry Shea
Publikováno v:
SLAS Discovery. 6:275-290
This paper describes, for the first time, a true ultra-high throughput screen (uHTS) based upon fluorescence anisotropy and performed entirely in 1536-well assay plates. The assay is based upon binding and displacement of a BODIPY-FL-labeled antibiot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1bcd9bb77ec205ec6cf92ff6fe690f2
https://doi.org/10.1177/108705710100600502
https://doi.org/10.1177/108705710100600502