Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Ulrich H. Weidle"'
Trop-2 induces ADAM10-mediated cleavage of E-cadherin and drives EMT-less metastasis in colon cancer
Autor:
Emanuela Guerra, Marco Trerotola, Valeria Relli, Rossano Lattanzio, Romina Tripaldi, Giovanna Vacca, Martina Ceci, Khouloud Boujnah, Valeria Garbo, Antonino Moschella, Romina Zappacosta, Pasquale Simeone, Robert de Lange, Ulrich H. Weidle, Maria Teresa Rotelli, Arcangelo Picciariello, Raffaella Depalo, Patrizia Querzoli, Massimo Pedriali, Enzo Bianchini, Domenico Angelucci, Giuseppe Pizzicannella, Carla Di Loreto, Mauro Piantelli, Laura Antolini, Xiao-Feng Sun, Donato F. Altomare, Saverio Alberti
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 9, Pp 898-911 (2021)
We recently reported that activation of Trop-2 through its cleavage at R87-T88 by ADAM10 underlies Trop-2–driven progression of colon cancer. However, the mechanism of action and pathological impact of Trop-2 in metastatic diffusion remain unexplor
Externí odkaz:
https://doaj.org/article/47c452d30d02427780fceca7aeda7338
Autor:
ULRICH H. WEIDLE, ADAM NOPORA
Publikováno v:
Anticancer Research. 42:3233-3249
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55b303d054279d95fa6611466eebda7c
https://doi.org/10.21873/anticanres.15813
https://doi.org/10.21873/anticanres.15813
Publikováno v:
Cancer Genomics - Proteomics. 19:283-298
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cea4cfbaefe66b459315a50379951a44
https://doi.org/10.21873/cgp.20320
https://doi.org/10.21873/cgp.20320
Autor:
ULRICH H. WEIDLE, ADAM NOPORA
Publikováno v:
Cancer Genomics - Proteomics. 19:113-129
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ad637d257e57feab186658da5a04c60
https://doi.org/10.21873/cgp.20308
https://doi.org/10.21873/cgp.20308
Autor:
ULRICH H. WEIDLE, FABIAN BIRZELE
Publikováno v:
Cancer Genomics Proteomics
Esophageal squamous cell carcinoma is a type of cancer with dismal prognosis. Surgery, chemo- and radiation therapy, as well as immune checkpoint-blocking immunotherapy lead to limited improvement of survival of patients; therapy resistance and recur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5948a0f30f4f3dfdb1726fa6e6e5730
https://europepmc.org/articles/PMC9247874/
https://europepmc.org/articles/PMC9247874/
Publikováno v:
Cancer Genomics - Proteomics. 18:497-514
In addition to chemotherapy, targeted therapies have been approved for treatment of locally advanced and metastatic gastric cancer. The therapeutic benefit is significant but more durable responses and improvement of survival should be achieved. Ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69cdc233994a98bdab71866c7f339865
https://doi.org/10.21873/cgp.20275
https://doi.org/10.21873/cgp.20275
Publikováno v:
Cancer Genomics Proteomics
The annual death toll for gastric cancer is in the range of 700,000 worldwide. Even in patients with early-stage gastric cancer recurrence within five years has been observed after surgical resection and following chemotherapy with therapy-resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee0793e92d9dfa54bce94aace332c5b
https://doi.org/10.21873/cgp.20237
https://doi.org/10.21873/cgp.20237
Publikováno v:
Transgenic Animals ISBN: 9781003211099
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95f924b1dbb0c7b55cfd65a90c89d123
https://doi.org/10.1201/9781003211099-91
https://doi.org/10.1201/9781003211099-91
Publikováno v:
Cancer Genomics - Proteomics. 17:651-667
During the last years a considerable therapeutic progress in melanoma patients with the RAF V600E mutation via RAF/MEK pathway inhibition and immuno-therapeutic modalities has been witnessed. However, the majority of patients relapse after therapy. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95d780b921a42f8e74f2ed61486964bb
https://doi.org/10.21873/cgp.20221
https://doi.org/10.21873/cgp.20221
Publikováno v:
Cancer Genomics Proteomics
The high death toll of colorectal cancer patients is due to metastatic disease which is difficult to treat. The liver is the preferred site of metastasis, followed by the lungs and peritoneum. In order to identify new targets and new modalities of in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0d6a8da5f20d554c30fb5e19f6d3f3
https://doi.org/10.21873/cgp.20204
https://doi.org/10.21873/cgp.20204