Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ulrich Emde"'
Autor:
Wolfgang Stähle, Soheila Anzali, David Bruge, Hans-Peter Buchstaller, Kai Schiemann, Ulrich Emde, Frank Zenke, Thorsten Knöchel, Christiane Amendt, Dirk Finsinger
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1491-1495
Here we describe the discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5 originally found during a high-throughput screening (HTS) campaign sampling our in-house compo
Autor:
Martin A. Berliner, Ulrich Emde, Jonathan T. Reeves, David R. Williams, Andre A. Kiryanov, Michael P. Clark
Publikováno v:
Proceedings of the National Academy of Sciences. 101:12058-12063
A highly convergent total synthesis of the potent anticancer agent (+)-phorboxazole A ( 1 ) is accomplished. Four components ( 3 – 6 ) are assembled with considerations for control of absolute and relative stereochemistry. Iterative asymmetric ally
Autor:
Michael P. Clark, Jonathan T. Reeves, Ulrich Emde, Andre A. Kiryanov, David R. Williams, Martin A. Berliner
Publikováno v:
Angewandte Chemie International Edition. 42:1258-1262
Autor:
Werner Mederski, Frank Zenke, Lars Damstrup, Thomas Fuchss, Lubo Vassilev, Klaus Urbahns, Andree Blaukat, Astrid Zimmermann, Christian Sirrenberg, Hans-Peter Buchstallter, Ulrich Emde
Publikováno v:
Cancer Research. 77:4198-4198
Physical or chemical agents that damage DNA such as ionizing radiation are among the most widely used classes of cancer therapeutics today. Double strand breaks (dsb) generated in DNA by radiation induce a multitude of cellular responses, including D
Publikováno v:
Organic Letters. 2:3023-3026
A stereoselective synthesis of the C(28)-C(46) fragment (3) of phorboxazole A is described. Key advances include an enantioselective allylation to establish the stereochemistry of the tetrahydropyran unit and a useful SmI(2)-mediated modification of
Publikováno v:
Angewandte Chemie. 112:2181-2184
Publikováno v:
Angewandte Chemie International Edition. 39:2099-2102
Autor:
Ulrich Emde, Ulrich Koert
Publikováno v:
European Journal of Organic Chemistry. 2000:1889-1904
The total syntheses of the Annonaceous acetogenins squamocin A and squamocin D have been achieved. The synthesis follows a modular strategy, wherein a left-side chain, the central bis-THF core and the right-side chain are assembled together. Key reac
Autor:
Ulrich Emde, Ulrich Koert
Publikováno v:
Tetrahedron Letters. 40:5979-5982
The total syntheses of two acetogenins, squamocin A and squamocin D, have been achieved. The adjacent bis-THF subunit was constructed by a multiple Williamson reaction. The left and the right side chain were added by addition of organomagnesium compo
Autor:
Ulrich Koert, Ulrich Emde
Publikováno v:
ChemInform. 30
The total syntheses of two acetogenins, squamocin A and squamocin D, have been achieved. The adjacent bis-THF subunit was constructed by a multiple Williamson reaction. The left and the right side chain were added by addition of organomagnesium compo