Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood

Autor: Jacqueline H.Y. Siu, Michael J. Pitcher, Thomas J. Tull, Rebekah L. Velounias, William Guesdon, Lucia Montorsi, Krishnaa T. Mahbubani, Richard Ellis, Pawan Dhami, Katrina Todd, Ulrich D. Kadolsky, Michelle Kleeman, David P. D’Cruz, Kourosh Saeb-Parsy, Mats Bemark, Gavin J. Pettigrew, Jo Spencer

Publikováno v: Spencer, J, Siu, J, Pitcher, M, Tull, T, Velounias, R, Guesdon, W, Montorsi, L, Mahbubani, K, Ellis, R, kadolsky, U, Kleeman, M, D'Cruz, D, Saeb-Parsy, K, Bemark, M & Pettigrew, G 2022, ' Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood ', Science Immunology, vol. 7, no. 69, pp. eabm9060 . https://doi.org/10.1126/sciimmunol.abm9060

B cells generate antibodies that are essential for immune protection, but their subgroups are poorly defined. Here, we perform undirected deep profiling of B cells in matched human lymphoid tissues from deceased transplant organ donors and blood. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4762e0943ff3340251596e49160cc3d8
https://doi.org/10.1126/sciimmunol.abm9060

Human marginal zone B cell development from early T2 progenitors

Autor: William Guesdon, Michael J. Pitcher, Yuan Zhao, Cristina Lebrero-Fernández, Richard Groves, Wayel Jassem, Michelle Kleeman, Susanne Heck, Yogesh Kamra, David J. Fear, David D'Cruz, Richard Ellis, Susan D. John, Ulrich D. Kadolsky, Nedyalko Petrov, Pawan Dhami, Jeremy D. Sanderson, Thomas J Tull, Mats Bemark, Jacqueline Hy Siu, Jo Spencer, Michael D. Robson

Publikováno v: Spencer, J, Tull, T, Pitcher, M, Guesdon, W, Siu, J HY, Lebraro-Fernandez, C, Zhao, Y, Petrov, N, Heck, S, Ellis, R, Dhami, P, kadolsky, U, Kleeman, M, Kamra, Y, Fear, D, John, S, Jassem, W, Groves, R, Sanderson, J D, Robson, M, D’Cruz, D & Bemark, M 2021, ' Human marginal zone B cell development from early T2 progenitors ', Journal of Experimental Medicine, vol. 218, no. 4, e20202001 . https://doi.org/10.1084/jem.20202001
The Journal of Experimental Medicine

This study identifies a developmental trajectory from human IgMhi gut homing transitional 2 cells to marginal zone B cells, all stages of which are affected in patients with severe systemic lupus erythematosus.
B cells emerge from the bone marro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb8c2c762c335e87f1bb70f46e6047e
https://doi.org/10.1101/2020.09.24.311498

The Leishmaniasis Model

Autor: Ingrid Müller, Pascale Kropf, Matthew E. Rogers, Ulrich D. Kadolsky, Thomas E. Cloke

Publisher Summary This chapter presents an overview of the Leishmaniasis model. Leishmaniasis is the general term given to at least three distinct complexes of diseases, including cutaneous, mucocutaneous, and visceral leishmaniasis. These different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d802ef54bf625f78b2172b7512455340
https://doi.org/10.1016/s0580-9517(10)37013-9

HLA Class I Binding of HBZ Determines Outcome in HTLV-1 Infection

Autor: Graham P. Taylor, Charles R. M. Bangham, Ulrich D. Kadolsky, Koichiro Suemori, Hiroshi Fujiwara, Aileen G. Rowan, Silva Hilburn, Becca Asquith, Masaki Yasukawa, Aidan MacNamara

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 6, Iss 9, p e1001117 (2010)

CD8+ T cells can exert both protective and harmful effects on the virus-infected host. However, there is no systematic method to identify the attributes of a protective CD8+ T cell response. Here, we combine theory and experiment to identify and quan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0821c739c9f104538862349061caa6c
https://doi.org/10.1371/journal.ppat.1001117